- Chemotherapy-induced neuropathic pain occurs commonly and is under-recognised and under-treated.
- It can compromise anti-cancer treatment and adversely affects quality of life and activities of daily living.
- Improvement of assessment and further research into treatment will help patients with this difficult pain.
References
Attal N, Cruccu G, Haanpaa M et al. EFNS guidelines on pharmacological treatment of neuropathic pain. Eur J Neurol. 2006; 13: 1153-69. Link to PubMed abstract
Cata JP, Weng HR, Lee BN et al. Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy. Minerva Anestesiol 2006; 72: 151-69 Link to PubMed abstract
Cersosimo RJ. Oxaliplatin-associated neuropathy: a review. Ann Pharmacother 2005; 39: 128-35. Link to PubMed abstract
Eriksson T, Bjorkman S, Hoglund P. Clinical pharmacology of thalidomide. Eur J Clin Pharmacol 2001; 57: 365-76. Link to PubMed abstract
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Hauscheer FH, Schilsky RL, Bain S et al. Diagnosis, management and evaluation of chemotherapy-induced periperhal neuropathy. Semin Oncol 2006; 33: 15-49: Link to PubMed Link to PubMed abstract
Quasthoff S, Hartung HP. Chemotherapy-induced peripheral neuropathy. J Neurol 2002; 249: 9-17. Link to PubMed abstract
Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, Goldschmidt H, Reece D, San-Miguel JF, Blade J, Boccadoro M, Cavenagh J, Dalton WS, Boral AL, Esseltine DL, Porter JB, Schenkein D, Anderson KC. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. E Engl J Med 2005; 352: 2487-98. Link to PubMed abstract
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Xiao W, Boroujerdi A, Bennett GJ, Luo ZD. Chemotherapy-evoked painful neuropathy: Analgesic effects of gabapentin and effects on expression of the alpha-2-delta type -1 calcium channel subunit. Neuroscience 2007; 144: 714-20. Link to PubMed abstract.
Wong GY, Michalak JC, Sloan LA, Loprinzi CL. A phase III double-blinded, placebo-controlled randomised trial of gabapentin in patients with chemotherapy-induced peripheral neuropathy. A North Central Cancer Group Study. J Clin Oncol 2005 23 [729s}, Abstract 8001.
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