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Definition: bisphosphonate-associated osteonecrosis of the jaw: an area of exposed bone in the maxillofacial region that did not heal with 8 weeks after identification by a healthcare provider, in a patient who was receiving or had been exposed to a bisphosphonate and had not had radiation therapy to the craniofacial region. (American Society for Bone and Mineral Research)
| 30 September 2009: The European Medicines Agency has completed a review on the risk of osteonecrosis of the jaw associated with the use of bisphosphonates. The Agency’s Committee for Medicinal Products for Human Use (CHMP) concluded that there is an increased risk of osteonecrosis of the jaw in patients using these medicines. [More] |
The following guidelines and systematic reviews have been identified through a systematic search of the literature as the best available evidence-based resources on the topic of bisphosphonates and osteonecrosis of the jaw. Guidelines are identified in association with the National Library for Guidelines and meet their inclusion criteria. The systematic reviews listed below have been critically appraised in accordance with our Quality Policy.
The reference materials and patient information included have been developed by government agencies, medical associations and charities.
Guidelines
Canadian consensus practice guidelines for bisphosphonate associated osteonerosis of the jaw: Canadian Association of Oral and Maxillofacial Surgeons. (2008) [view]
Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. (2007) [view]
American Society of Clinical Oncology clinical practice guideline update on the role of bisphosphonates in multiple myeloma (2007) [view]
Cancer Care Ontario: The role of bisphosphonates in the management of skeletal complications for patients with multiple myeloma: a clinical practice guideline (2007) [view]
Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma (2006) [view]
Systematic reviews
Osteonecrosis of the jaw and use of bisphosphonates in adjuvant breast cancer treatment: a meta-analysis (2009) [view]
Bisphosphonate associated osteonecrosis of the jaw (2009) [view]
What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review (2009) [view]
A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics (2007) [view]
Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws (2006) [view]
Bisphosphonates and osteonecrosis of the jaw: cause and effect or a post hoc fallacy? (2006) [view]
Reference material:
MHRA:
- Bisphosphonates and osteonecrosis of the jaw (2007) [view]
- Osteonecrosis of the jaw with bisphosphonates (2006) [view]
FDA: Osteonecrosis of the jaw: important drug precaution (2005) [view]
Bandolier: Bisphosphonates and jaw necrosis (2006) [view]
Patient information
Cancer Research UK: About bisphosphonates and jaw problems [view]
American Dental Association:
- Bisphosphonate medications and your oral health [view]
- Osteoporosis medications and the risk of developing jaw complications [view]
American Academy of Oral Medicine: Bisphosphonate therapy and the oral cavity [view]
British Osteoporosis Foundation: Osteonecrosis of the Jaw (ONJ) [view]
