UK Database of Uncertainties about the Effects of Treatments (DUETs) Resource List
"As needed" versus continuously scheduled antimuscarinic therapy for urinary incontinence
308nm excimer laser for repigmentation in vitiligo
308nm excimer laser plus topical calcipotriol for repigmentation in vitiligo
308nm excimer laser plus topical hydrocortisone 17-butyrate for repigmentation in vitiligo
A 35 yr old with DVT has just stopped warfarin after 6 months. Is there any evidence for him taking Aspirin (75mg-300mg) life-long to prevent recurrence?
A co-ordinated approach of primary and secondary care in the early diagnosis and management of schizophrenia
A randomised controlled trial of outcomes in incidental venous thromboembolism (an observational study and follow-up RCT of treatment versus no treatment if indicated).
A review of the effectiveness of oral health promotion activities among elderly people
Abatacept for rheumatoid arthritis
Abdominal drainage versus no drainage post gastrectomy for gastric cancer
Absence of carious lesions at margins of glass-ionomer and amalgam restorations
Acamprosate for alcohol dependence
ACE inhibitors for the reduction of portal pressure in Child-Pugh class A cirrhosis
Acetylcholinesterase inhibitor treatment for myasthenia gravis
Acetylcholinesterase inhibitors and memantine for the treatment of psychotic symptoms in dementia over six months
Acetylcholinesterase inhibitors for schizophrenia
Acetylcholinesterase inhibitors for schizophrenia
Acid reflux treatment for hoarseness
Action plans for chronic obstructive pulmonary disease
Action plans with limited patient education only for exacerbations of chronic obstructive pulmonary disease
Active case finding in contacts of people with tuberculosis
Active chest compression-decompression for cardiopulmonary resuscitation
Active placebos versus antidepressants for depression
Active specific immunotherapy for malignant melanoma
Acupressure for motion sickness
Acupuncture and moxibustion for acne
Acupuncture and related interventions (acupressure, laser therapy or electrostimulation) for smoking cessation
Acupuncture for acute management and rehabilitation of traumatic brain injury
Acupuncture for asthma
Acupuncture for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents
Acupuncture for autism spectrum disorders (ASD)
Acupuncture for Bell's palsy
Acupuncture for bladder dysfunction after spinal cord injury
Acupuncture for chronic asthma
Acupuncture for depression
Acupuncture for epilepsy
Acupuncture for glaucoma
Acupuncture for Ménière's Syndrome
Acupuncture for nocturnal enuresis
Acupuncture for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Acupuncture for pain in endometriosis
Acupuncture for polycystic ovarian syndrome
Acupuncture for rheumatoid arthritis
Acupuncture for schizophrenia
Acupuncture for schizophrenia
Acupuncture for slowing the progression of myopia in children and adolescents
Acupuncture for tinnitus
Acupuncture for urinary incontinence in adults without neurological disease
Acupuncture for xerostomia
Acupuncture in poststroke rehabilitation
Acupuncture or acupressure for pain management in labour
Acupuncture vs routine care for tension-type headache
Acupuncture vs sham treatments for tension-type headache
Acute day hospitals compared to other acute service provision, such as crisis resolution and home treatment teams for serious mental illness
Adding leukotriene antagonists to inhaled corticosteroids in people with mild to moderate, persistent asthma
Additional bedtime H2-receptor antagonist for the control of nocturnal gastric acid breakthrough
Adenotonsillectomy for obstructive sleep apnoea in children
Adjunctive antithyroid drugs in radioiodine therapy for hyperthyroidism
Adjusting the pH of lidocaine for reducing pain on injection
Adjuvant antiviral therapy for recurrent respiratory papillomatosis
Adjuvant chemotherapy for endometrial cancer after hysterectomy
Adjuvant chemotherapy for small intestine adenocarcinoma
Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy induced premature ovarian failure in premenopausal women
Adjuvant radiotherapy following radical prostatectomy for pathologic T3 or margin-positive prostate cancer
Adjuvant radiotherapy following radical prostatectomy for prostate cancer
Adjuvant radiotherapy for stage I endometrial cancer
Adjuvant therapy for completely resected stage II colon cancer
Adrenergic drugs for urinary incontinence in adults
Adrenergic drugs for urinary incontinence in comparision with alternative approaches to the care of people with stress urinary incontinence
Advance treatment directives for people with severe mental illness
Advanced trauma life support training for ambulance crews
Advantages and disadvantages of alternative types of oestrogen therapy in treating post-menopausal women with urinary incontinence.
Adventitial sheathotomy in branch retinal vein occlusion
Adverse effects in women taking Pentoxifylline for the treatment of endometriosis?
Adverse effects of anti-epileptic drugs medication in pregnancy
Adverse effects of biologics: a network meta-analysis and Cochrane overview
Advising patients to increase fluid intake for treating acute respiratory infections
Air pollution: no evidence was identified regarding asthma and indoor air pollutants, such as volatile organic compounds, formaldehyde or nitrogen oxide
Alarms, desmopressin or tricyclic drug treatment as the first line management of nocturnal enuresis in children
Aldosterone blockers for heart failure
Allergen injection immunotherapy for perennial allergic rhinitis
Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remission
Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma
Almitrine-Raubasine combination for dementia
Alpha blockers for removal of urethral catheter after acute urinary retention in men
Alprazolam for depression
Altered dietary salt intake for preventing and treating diabetic kidney disease
Alternative and complementary therapies for psoriasis
Amantadine for depression
Amifostine for salivary glands in high-dose radioactive iodine treated differentiated thyroid cancer
Aminosalicylates for induction of remission or response in Crohn's disease
Amitriptyline for depression
Amplification for auditory neuropathy
An overview of reviews evaluating the effectiveness of financial incentives in changing healthcare professional behaviours and patient outcomes
Anaesthesia for treating distal radial fracture in adults
Anakinra compared to other biological therapies for rheumatoid arthritis
Analgesia for amniocentesis or chorionic villus sampling
Analgesia for relief of pain due to uterine cramping/involution after birth
Analimumab for fistulizing Crohn's disease
Andrenoceptor agonists for urinary incontinence
Angiogenesis inhibitors for the treatment of ovarian cancer
Angiogenesis-inhibitors for metastatic thyroid cancer
Angioplasty versus stenting for subclavian artery stenosis
Angiotensin receptor blockers for heart failure
Angiotensin receptor blockers for the reduction of portal pressure in Child-Pugh class A cirrhosis
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease
Annual Chest X-Rays in successfully treated cases of Head & Neck cancer
Antenatal breastfeeding education for increasing breastfeeding duration
Antenatal care programmes to reduce infant mortality and preterm birth in socially disadvantaged and vulnerable women in high-income countries.
Antenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant
Antenatal screening for haemoglobinopathies in primary care: a cluster randomised trial to inform a simulation model
Anti-adhesion molecules for Crohn's disease
Anti-angiogenic therapies for metastatic colorectal cancer in patients with cardiovascular disease or a history of prior thromboembolic events
Antiangiogenic therapy with anti-vascular endothelial growth factor (anti-VEGF) modalities to treat diabetic macular oedema
Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neovascular age-related macular degeneration
Antibiotic prophylaxis for patients undergoing elective laparoscopic cholecystectomy
Antibiotic prophylaxis for preventing infection in open finger fractures
Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures
Antibiotic prophylaxis for transrectal prostate biopsy
Antibiotic therapy for preventing infections in patients with acute stroke
Antibiotics for acute maxillary sinusitis
Antibiotics for acute otitis media in children; effects on subgroups
Antibiotics for chronic osteomyelitis in adults
Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections
Antibiotics for persistent nasal discharge (rhinosinusitis) in children
Antibiotics for preventing meningococcal infections
Antibiotics for prolonged moist cough in children
Antibiotics for the prophylaxis of bacterial endocarditis in dentistry
Antibiotics for trachoma
Antibiotics for treating osteomyelitis in people with sickle cell disease
Antibiotics for treating salmonella gut infections
Antibiotics in 'clean' foot ulcers in people with diabetes
Antibiotics versus control for toxoplasma retinochoroiditis
Anticholinergic drugs for nocturnal enuresis (oxybutynin, tolterodine, hyoscyamine)
Anticholinergic drugs, compared to other drugs for overactive bladder symptoms
Anticholinergic medication for neuroleptic-induced tardive dyskinesia
Anticholinergic therapy for acute asthma in children
Anticholinergic therapy for acute asthma in children
Anticholinergics for neuroleptic-induced acute akathisia
Anticholinergics for neuroleptic-induced parkinsonism
Anticholinergics for urinary symptoms in multiple sclerosis
Anticholinerigic drugs, bladder training or the combination of the two for the management of overactive bladder symptoms
Anticoagulation for cerebral venous sinus thrombosis
Anticoagulation for heart failure in sinus rhythm
Anticoagulation for patients with cancer and central venous catheters
Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer
Anticonvulsants for tinnitus
Anticonvulsants for tinnitus
Anti-cytomegalovirus treatment in patients with ulcerative colitis
Antidepressant drugs for older people
Antidepressant medication for children with depression
Antidepressants for agitation and psychosis in dementia
Antidepressants for depressed elderly
Antidepressants for pain management in rheumatoid arthritis
Antidepressants for painful rheumatological conditions
Antidepressants for people with both schizophrenia and depression
Antidepressants for the negative symptoms of schizophrenia
Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents
Antidepressants for tinnitus
Antidepressants plus benzodiazepines for major depression
Antidepressants versus placebo for depression in primary care
Antidepressants versus placebo for the depressed elderly
Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood
Anti-epileptic drugs (AEDs) and the risk of teratogenic effects when taken during pregnancy
Antiepileptic drugs for preventing seizures in people with brain tumors
Antiepileptic drugs for the primary and secondary prevention of seizures after stroke
Antiepileptic drugs for treating seizures in adults with brain tumours
Antiepileptic treatments for seizures in multiple sclerosis
Antiglucocorticoid and related treatments for psychosis
Anti-hypertensive drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies and clinical trials
Anti-IgE for chronic asthma in adults and children
Anti-inflammatory drugs and risk of Parkinson disease
Anti-inflammatory nasal sprays for the prevention of acute otitis media
Antimuscarinic drugs for urinary incontinence for frail and institutionalised older people
Antimuscarinic drugs for urinary incontinence in people with dementia and/or Parkinsons disease, and frail older person taking cholinergic agents for dementia
Antimuscarinic medication and inpatient bladder retraining for urinary incontinence
Antioxidant micronutrients for lung disease in cystic fibrosis
Antioxidant multivitamin supplements in malnourished people to slow progression of age-related macular degeneration to more severe stages of the disease
Anti-oxidant pool (vitamins C & E, alpha-lipoic acid and polyunsaturated fats) plus narrow band UVB for repigmentation in vitiligo
Antioxidant supplements for liver diseases
Antioxidant supplements for liver diseases
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Antioxidants as adjuvants to other drugs in liver diseases
Antioxidants for Friedreich ataxia
Antiplatelet agents for intermittent claudication
Antiplatelet agents including aspirin for the prevention of coronary heart disease (CHD) in diabetes with particular attention to high risk groups (e.g. patients with renal disease and hypertensive disease)
Antiplatelet therapy for subarachnoid haemorrhage.
Antipsychotic drug discontinuation phenomena
Antipsychotic drugs for older people with schizophrenia
Antipsychotic drugs for younger people with psychosis
Antipsychotic drugs in first episode of schizophrenia
Antipsychotic medication for childhood-onset schizophrenia
Antipsychotic medication for early episode schizophrenia
Antipsychotic medication for elderly people with schizophrenia
Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems
Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems.
Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples
Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples
Antistreptococcal interventions for guttate and chronic plaque psoriasis
Antithrombin III to decrease blood loss and blood transfusion requirements for liver resection
Antithyroid drugs plus radioactive iodine for primary hyperthryoidism
Antithyroid drugs plus thyroxine compared with antithyroid drugs alone for primary hyperthyroidism
Antithyroid treatment for subclinical hyperthyroidism
Anti-TNF agents for prevention of post-operative recurrence of Crohn's disease
Anti-TNF therapy in inflammatory bowel disease during conception
Anti-vascular endothelial growth factor agents for treatment of macular edema secondary to central retinal vein occlusion
Anti-vascular endothelial growth factor for branch retinal vein occlusion
Anti-vascular endothelial growth factor for macular edema secondary to central retinal vein occlusion
Anti-vascular endothelial growth factor for neovascular glaucoma
Anti-vascular endothelial growth factor for prevention of postoperative vitreous cavity haemorrhage after vitrectomy for proliferative diabetic retinopathy
Antiviral prophylactic intervention for chronic hepatitis C virus in patients undergoing liver transplantation
Antiviral therapy for chronic hepatitis C in injecting drug users
Antiviral therapy for chronic hepatitis C in patients coinfected with HBV
Antiviral therapy for chronic hepatitis C in patients coinfected with HIV
Antiviral therapy for chronic hepatitis C in patients who did not respond to treatment with peginterferon plus ribavirin or relapsed following it
Antiviral therapy for chronic hepatitis C in patients with haemophilia
Antiviral therapy for chronic hepatitis C in patients with histologically mild disease
Antiviral therapy for chronic hepatitis C in patients with normal ALT levels
Antiviral therapy for hepatitis C patients without rapid virological response
Antiviral therapy for recurrent liver graft infection with hepatitis C virus
Antiviral therapy in patients with Hepatitis B virus DNA levels of >=20,000 IU/mL and normal ALT levels
Antiviral treatment and other therapeutic interventions for herpes simplex viRCs epithelial keratitis
Antivirals alone or combined with immunoglobulin for the prevention of hepatitis B recurrence after liver transplantation
Any multivitamin or single component antioxidant supplement for age-related macular degeneration to slow or prevent progression
Any versus no fluid resuscitation in acute upper gastrointestinal haemorrhage
Appendectomy versus antibiotic treatment for acute appendicitis
Appropriate duration and optimal treatment regimen of anti-vascular endothelial growth factor modalities for exudative age-related macular degeneration
Appropriate duration and optimal treatment regimen of anti-vascular endothelial growth factor modalities for neovascular age-related macular degeneration
Aprotinin to decrease blood loss and blood transfusion requirements for liver resection
Aquatic exercise for knee or hip osteoarthritis
Aqueous shunts for glaucoma
Are alternative treatments helpful for asthma in children?
Are Angiotensin converting enzyme inhibitors (ACE inhibitors) more effective than Angiotensin II receptor antagonists (AIIRA's) in reducing progression of kidney disease and reducing mortality in people with diabetes?
Are antipsychotic drugs more effective when combined with a mood stabilizer in severe mental illness?
Are antipsychotics bad for my sleep
Are any complementary therapies effective in preventing the severity, frequency and progression of attacks of Ménière's disease?
Are botulinum toxin injections effective in reducing enuresis?
Are botulinum toxin injections in patients previously treated with bulking agents for stress urinary incontinence associated with adverse outcomes?
Are breathing exercises helpful for asthma in children?
Are breathing exercises helpful in controlling asthma?
Are Buteyko breathing exercises helpful in controlling asthma?
Are Buteyko breathing exercises helpful in controlling asthma?
Are Buteyko breathing exercises helpful in controlling asthma?
Are Buteyko breathing exercises useful for asthma?
Are calcineurin inhibitors (tacrolimus or pimecrolimus) effective in treating vitiligo?
Are calcineurin inhibitors (tacrolimus or pimecrolimus) more effective if used to treat vitiligo when it first appears, rather than waiting until the disease has spread?
Are calcineurin inhibitors (tacrolimus or pimecrolimus) more effective in treating vitiligo when combined with steroid creams?
Are Chinese herbal medicine Huangqi type formulations effective as treatment for nephrotic syndrome?
Are complementary therapies effective in the treatment of stress urinary incontinence?
Are complex multi-dose insulin regimes a safe and effective treatment in elderly people with Type 1 and Type 2 diabetes?
Are cranberry juice and other alternative or complimentary therapies effective in reducing urinary tract infections?
Are creams and ointments (e.g. steroid creams) more effective when combined with natural sunlight?
Are disposable catheters more or less accepatable than reusable catheters in terms of effective bladder management, patient experience and urinary tract infections?
Are doctors favouring different drugs for the same condition on the basis of financial incentives?
Are Enbrel (etanercept) anti-inflammatory injections a safe and effective treatment for severe asthma uncontrolled by oral and inhaled steroids?
Are exercise-based therapies successful in the treatment of urge urinary incontinence?
Are exposure therapy and/or systematic desensitisation safe and effective treatments for misophonia?
Are general practice teams useful in crisis management of people with schizophrenia?
Are home-based exercises given to patients with balance disorders effective?
Are homeopathic medicines helpful in asthma?
Are immunosuppressive treatments effective for focal segmental glomerulosclerosis in adults?
Are insulin analogues a safe long-term treatment for adults with Type 1 and Type 2 diabetes?
Are insulin analogues a safe long-term treatment for children with Type 1 and Type 2 diabetes?
Are insulin analogues a safe long-term treatment for pregnant women with Type 1 and Type 2 diabetes and their unborn babies?
Are insulin analogues a safe long-term treatment for those with complications and the elderly with Type 1 and Type 2 diabetes?
Are insulin analogues a safe long-term treatment for Type 1 and Type 2 diabetes?
Are Insulin Pens accurate at delivering insulin, even in small doses?
Are moisturisers effective in stopping the spread of vitiligo?
Are mortality rates and complication rates for the human, analogues and animal insulin's different?
Are natural thermal mineral waters effective in knee osteoarthritis?
Are novel immunotherapy treatments such as banked HLA-matched (human leucocyte antigen) cytotoxic T lymphocytes (CTLs) effective in kidney transplant patients with Post Transplant Lymphoproliferative Disorders?
Are phosphodiesterase inhibitors safe in people with diabetes mellitus who have coronary artery disease?
Are postmanoeuvre activity restrictions necessary after canalith repositioning procedure?
Are prophylactic antibiotics more effective than lifestyle advice for the reduction of urinary tract infections?
Are proven risk reductions in macrovascular disease in diabetes when employed simultaneously, additive, multiplicative or otherwise?
Are psychological interventions less effective in older people with severe mental illness?
Are psychological therapies helpful for asthma compared to drugs?
Are rapid-acting insulin analogues beneficial in children and adolescents?
Are saunas and swimming good for controlling asthma?
Are side effects of antipsychotics proportional to their effectiveness?
Are social activities beneficial for schizophrenia?
Are steroid creams more effective if used to treat vitiligo when it first appears, rather than waiting until the disease has spread?
Are steroids better taken by inhaling them or in tablet form for controlling asthma in children?
Are stress management techniques helpful in patients with balance disorders
Are the adverse effects of antipsychotic drugs worse in the morning?
Are the drugs used to treat maternal asthma harmful to the infant during breastfeeding?
Are the phosphodiesterase inhibitors as effective as other therapeutic options to treat erectile dysfunction?
Are there advantages of taking a squirt of Ventolin prior to the regular twice daily Flixotide dose?
Are there any advantages of combined antihistamine preparations (e.g. Arlevert) for the management of Ménière's disease?
Are there any alternatives to drugs which help in asthma?
Are there any complementary therapies or supplements that help in asthma?
Are there any dietary measures that can prevent prostate cancer or slow its progression?
Are there any effective interventions for the ear pressure symptoms in Ménière's disease?
Are there any effective surgical interventions for asthma?
Are there any long term side effects associated with steroid cream treatments?
Are there any long-term carcinogenic risks associated with treatment with insulin analogues?
Are there any non-drug alternatives to manage my asthma?
Are there any non-intrusive diagnostic tests that will identify aggressive prostate cancers whilst not identifying harmless cancers?
Are there any 'rapid relief' interventions for acute vertigo in Ménière's disease other than vestibular sedatives?
Are there any risks associated with depigmentation in treating vitiligo?
Are there any self-administered, cheap, easy and safe therapies that patients have discovered that help balance problems?
Are there any side effects associated with permanent, or semi-permanent, cosmetic camouflage for the management of vitiligo?
Are there any side effects associated with using calcineurin inhibitors (tacrolimus or pimecrolimus) to treat vitiligo?
Are there any side effects associated with using piperine (black pepper) cream to treat vitiligo?
Are there any side effects associated with using pseudocatalase cream combined with UVB light therapy in treating vitiligo?
Are there any side effects associated with using steroid creams in treating vitiligo?
Are there any side effects associated with using UVA light therapy in treating vitiligo?
Are there any side effects associated with UVB light therapy in treating vitiligo?
Are there any specific techniques that patients can adopt (e.g. certain visual or positional strategies) that can help in an acute attack of Ménière's disease?
Are there benefits of hospital treatment compared to home care treatment for psychotic episodes?
Are there differences between the mortality and complication rates found in people who use human analogue and animal insulins?
Are there differences in efficacy between the 3 phosphodiesterase inhibitors available in UK?
Are there long term adverse effects of ECT for schizo-affective disorders
Are there suitable long-term pharmacological interventions to be recommended postnatally for women who have been diagnosed with gestational diabetes to prevent the onset of type 2 diabetes?
Are topical tacrolimus and pimecrolimus for atopic eczema safe or can they cause lymphoma or skin cancer?
Are vaginal cones an effective therapy for women with post natal stress urinary incontinence?
Are Vitamin D analogues (calcipotriol and tacalcitol) more effective in treating vitiligo when combined with light therapy?
Are Vitamin D analogues (calcipotriol and tacalcitol) more effective in treating vitiligo when combined with steroid creams?
Are weighted vaginal cones effective for urinary incontinence?
Aripiprazole versus placebo for schizophrenia
Aromatherapy for pain management in labour
Aromatherapy massage for whiplash neck injury?
Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria
Artesunate versus quinine for treating severe malaria
Arthroplasties (with or without bone cement) for proximal femoral fractures in adults
Arthroscopic debridement from knee osteoarthritis
Arthroscopy for temporomandibular disorders
'As required' medication regimens for seriously mentally ill people in hospital
Aspiration of middle-ear effusions prior to insertion of ventilation tubes
Aspirin compared to other triptans and NSAIDS and acute migraine
Aspirin for in vitro fertilisation
Aspirin versus low molecular weight heparin as thromboprophylaxis in surgical, particularly orthopaedic, patients.
Assertive community treatment for people with severe mental disorders in the UK
Assertive Outreach Teams (AOT) for schizophrenia and other serious mental disorders in the UK
Assessment of the value of neuropathic pain medication for treatment of chronic pelvic pain in women
Assistive technology for rheumatoid arthritis
At what age should preventative use of statins be started in those with Type 1 diabetes?
At what point following start of statins and other Coronary Vascular Disease risk-modification is it appropriate to reduce/withhold blood pressure lowering agents?
Auditory integration training and other sound therapies for autism spectrum disorders
Augmentation of antipsychotic monotherapy with lithium where a schizophrenic illness has shown only a partial response
Augmentation of antipsychotic monotherapy with sodium valproate where a schizophrenic illness has shown only a partial response
Augmentation of clozapine monotherapy with an appropriate second antipsychotic where a refractory schizophrenic illness has shown only a partial response to clozapine
Augmenting antipsychotic monotherapy with an antidepressant to treat persistent negative symptoms
Autoinflation for hearing loss associated with otitis media with effusion
Autologous blood donation to decrease blood loss and blood transfusion requirements for liver resection
Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas
Ayurvedic medicine for schizophrenia
Ayurvedic treatments for diabetes mellitus
Azathioprine (low dose) plus PUVA for repigmentation in vitiligo
Azathioprine for psoriasis
Azathioprine or 6-mercaptopurine for induction of remission in fistulizing Crohn's disease
Azathioprine or 6-mercaptopurine to induce mucosal healing in Crohn's disease
Azelaic acid for acne
Azithromycin for treating uncomplicated malaria
B12 for pernicious anaemia dosing frequencies based on the patients’ symptoms rather than on number value of serum B12 blood tests
Balloon kyphoplasty for vertebral compression fractures
Balneotherapy for osteoarthritis
Balneotherapy for psoriasis
Balneotherapy for psoriatic arthritis
Balneotherapy for rheumatoid arthritis
Balsalazide versus mesalazine for maintenance of remission in ulcerative colitis
Balsalazide versus sulfasalazine for induction and maintenance of remission in ulcerative colitis
Bare-metal stenting compared with balloon angioplasty in patients with acute myocardial infarction
Bariatric surgery for non-alcoholic steatohepatitis in obese patients
Bariatric surgery in the treatment of severely obese adolescents?
Bath emollients for atopic eczema
Bed rest in hospital for suspected impaired fetal growth
Bee venom acupuncture for rheumatoid arthritis
Behavioral interventions for urinanry incontinence in acute care settings
Behavioral interventions to promote condom use among women living with HIV
Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in high-income countries
Behavioural counselling to reduce incidences of skin cancer
Behavioural treatments for non-epileptic attack disorder
Benefit, tolerability, and safety of drugs used to treat urinary incontinenece in frail older people
Benefits and harms of biliary stenting via ERCP for pancreatico-biliary stricture confirmed or suspected to be malignant, prior to surgery?
Benzodiazapines for catatonia in persons with schizophrenia and other serious mental illnesses.
Benzodiazepines and antipsychotic drugs for urgent urgent sedation/control of acute behavioural disturbance
Benzodiazepines for neuroleptic-induced tardive dyskinesia
Benzodiazepines for psychosis-induced aggression or agitation
Benzodiazepines for schizophrenia
Best psychological treatment for effective treatment of functional non-epileptic attacks
Beta radiation for glaucoma surgery
Beta2-receptor polymorphism for improving long-term beta-agonist efficacy in asthma
Beta2-receptor polymorphism for improving long-term beta-agonist efficacy in asthma
Beta-blockers for congestive heart failure in children
Beta-blockers for slowing/halting the progress of aortic root dilation
Beta-blockers for slowing/halting the progress of aortic root dilation in people with Marfans syndrome
Betahistine for Ménière's disease or syndrome
Betamimetics for suspected impaired fetal growth
Bevacizumab (safety and efficacy) in the treatment of age-related macular degeneration
Bezafibrate for primary biliary cirrhosis
Bicarbonate versus lactate solutions for acute peritoneal dialysis
Bicyclol for chronic hepatitis B
Bicyclol for chronic hepatitis C
Bile acids for non-alcoholic fatty liver disease and/or steatohepatitis
Biofeedback for Ménière's disease.
Biofeedback for stress urinary incontinence
Biologics for juvenile idiopathic arthritis
Biologics for rheumatoid arthritis
Biopsy versus resection for high grade glioma
Bismuth subsalicylate for lymphocytic colitis or collagenous colitis
Bisphosphonate therapy for children and adolescents with secondary osteoporosis
Bisphosphonates and atrial fibrillation
Bisphosphonates for osteoporosis in primary biliary cirrhosis
Bisphosphonates for osteoporotic fractures
Black pepper extract or piperine for repigmentation in vitiligo
Bladder retraining protocols for treating urinary incontinence
Bladder training in the management of overactive bladder symptoms
Bladder training in the management of urinary incontinence
Bone anchored hearing aids for patients with congenital unilateral aural atresia
Bone augmentation procedures in implant dentistry
Botulinium toxin A in the treatment of idiopathic detrusor overactivity
Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy
Botulinum toxin for shoulder pain
Botulinum toxin for spasmodic dysphonia
Botulinum toxin for subacute/chronic neck pain
Botulinum toxin injections for adults with overactive bladder symptoms
Botulinum toxin type A in the treatment of lower limb spasticity in cerebral palsy
Breast feeding and development of childhood wheeze
Brief interventions for heavy alcohol users admitted to general hospital wards
Broad band UVB monotherapy for repigmentation in vitiligo
Broad-spectrum light sources for acne
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants
Buccal or sublingual misoprostol for cervical ripening and induction of labour
Budesonide for lymphocytic colitis
Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome
Bupropion for depression
Caesarean delivery for the second twin
Caesarean section versus vaginal delivery for preventing mother to infant hepatitis C virus transmission
Caffeine reduction for urinanry incontinence in frail elderly people
Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients
Calcipotriol plus PUVA or UVB for psoriasis
Calcitriol and alfacalcidol for preventing fractures and falls
Calcium antagonists as an add-on therapy for dRCg-resistant epilepsy
Calcium antagonists for Duchenne muscular dystrophy
Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Calcium supplementation for hip fracture
Can a change in anti-epileptic drug timing affect seizure control?
Can a large anti-epileptic drug dosage lead to an increase in seizure frequency in some individuals?
Can a non-pharmaceutical treatment be the primary one for psychosis?
Can acute deterioration of asthma be prevented? i.e. appropriate treatment 48 hours earlier; role of “At Risk” registers
Can angiotensin-converting enzyme (ACE) inhibitors and ACE angiotensin II receptor blockers (ARB) be used in combination to treat early diabetic nephropathy?
Can antibiotics be stopped after 6 or 12 weeks, and therapy continued with a non-antibiotic-based regimen such as benzoyl peroxide or a topical retinoid?
Can anti-epileptic drugs interfere with blood results?
Can antiviral therapy induce remission of proteinuria in paediatric patients?
Can asthma medication at bedtime keep my child awake?
Can avoiding chocolate influence acne severity?
Can babies experience anti-epileptic drug withdrawal?
Can botulinum toxin injections be effective in treating nocturia?
Can bulking agents for stress urinary incontinence worsen urge incontinence?
Can children newly diagnosed with type 1 diabetes be stabilised at home or do all need hospital admission?
Can EBV monitoring, such as measuring viral loads and responses such as cytotoxic T-cell counts, be effective in patients with Post Transplant Lymphoproliferative Disorders?
Can effective treatment of irritable bowel syndrome reduce lower urinary tract symptoms associated with prostate disease?
Can epilepsy treatment cause Dupuytren's?
Can guidance or training for general practitioners on appropriate pathways of care improve the management of patients with urinary incontinence?
Can house dust mites worsen atopic eczema?
Can I have a nebuliser at home?
Can IV aminophylline be used preventatively for people with difficult to treat asthma?
Can long term use of steroids for asthma cause problems with your liver?
Can modified diet influence acne severity?
Can my asthmatic child participate in sport at school?
Can non-pharmaceutical treatment be used as a primary intervention in psychosis?
Can overdose/misuse of antipsychotic drugs cause psychotic symptoms?
Can overuse of salbutamol whilst taking becotide make one's asthma worse?
Can patients have a nebuliser at home to treat their asthma?
Can pelvic floor muscle training be effective in preventing incontinence associated with an overactive bladder?
Can people with schizophrenia be diagnosed earlier by GPs, and can the management of first episode psychosis be carried out in general practice?
Can pre-hospital clinicians perform Femoral Nerve Block safely and effectively in those with proximal femoral fracture?
Can pre-hospital clinicians perform urinary catheterisation safely and effectively in patients with proximal femoral fracture?
Can some individuals benefit from lower antiepileptic drug dosages than the therapeutic range suggested?
Can squamous cell cancer of the skin in an ageing UK population be reduced using currently available cream treatment for actinic keratoses?
Can telemedicine be used to raise the use of blood glucose monitoring in adolescent and young people with diabetes, in particular?
Can the way of measuring psoriasis and psoriatic arthritis in adults be improved?
Can too high a dose of antipsychotic cause psychotic symptoms?
Can we manage acne without resorting to antibiotics and help to curb the rise of antibiotic resistance?
Canaloplasty for primary open-angle glaucoma
Cancer genetic risk assessment for individuals at risk of familial breast cancer
Canine scent detection methods for early diagnosis of human cancers
Cannabinoid type 1 receptor antagonists for smoking cessation
Cannabinoids for Tourette's Syndrome
Capsaicin for allergic rhinitis in adults
Carbamazepine for schizophrenia
Carbamazepine versus valproate monotherapy for epilepsy
Carbohydrates for improving the cognitive performance of independent-living older adults with normal cognition or mild cognitive impairment
Cardiac resynchronisation therapy (CRT) in patients with atrial fibrillation compared with those with sinus rhythm
Cardiac resynchronisation therapy (CRT) versus optimal medical therapy in chronic heart failure patients with symptoms refractory to optimal medical therapy
Cardiac resynchronisation therapy with with implantable defibrilator (CRT-D) versus implantable cardioverter defibrilator (ICD) to reduce all-cause mortality in chronic heart failure patients
Cardiac testing for coronary artery disease in potential kidney transplant recipients
Care delivery and self management strategies to improve outcomes for people with epilepsy
Care delivery and self-management strategies for children with epilepsy
Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth
Carnitine supplementation for preterm infants with recurrent apnoea
Carotid endarterectomy or carotid artery stenting to prevent stroke
catheter ablation procedures in south-western europe
Celiac plexus block for pancreatic cancer pain in adults
Certolizumab pegol (CDP870) for rheumatoid arthritis in adults
Certolizumab pegol for Crohn's disease
Cervical pessary for preventing preterm birth
Cesarean delivery for the prevention of anal incontinence in average risk pregnancies
Cetuximab in combination with radiotherapy compared with chemoradiotherapy in patients with head and neck cancer
Cetuximab in combination with radiotherapy compared with radiotherapy alone in patients with head and neck cancer
Chemoembolisation combined with liver resection for neuroendocrine tumours in patients with resectable liver metastases
Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma
Chemoradiation versus hyperthermia versus chemoradiation plus hyperthermia for locally advanced rectal cancer
Chemoradiotherapy for pancreatic carcinoma in patients with no disease progression following 3-4 months of induction chemotherapy
Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma
Chemotherapy and surgery versus surgery alone in non-small cell lung cancer
Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease
Chemotherapy for metastatic carcinoma of the esophagus and gastro-esophageal junction
Chemotherapy given before or after the radiotherapy in locally advanced nasopharyngeal carcinoma
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer
Chemotherapy wafers for high grade glioma
Chinese and Indian herbal medications for repigmentation in vitiligo
Chinese Herbal Medicine (CHM) in the treatment of women with endometriosis
Chinese Herbal Medicine (CHM) in the treatment of women with primary dysmenorrhoea
Chinese herbal medicine for atopic eczema
Chinese herbal medicine for subfertile women with polycystic ovarian syndrome
Chinese herbal medicines combined with other routine treatment for hyperthyroidism
Chinese herbal medicines for hypercholesterolemia
Chinese herbal medicines for induction of remission in advanced or late gastric cancer
Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose and the delay of diabetes onset
Chinese medicinal herbs for alleviating chemotherapy-induced short term side effects in breast cancer patients
Chinese medicinal herbs for sore throat
Chinese zengse pill for repigmentation in vitiligo
Chiropractic medicine for Ménière's disease
Cholestyramine for lymphocytic colitis or collagenous colitis
Chorioretinal venous anastomosis for central retinal vein occlusion
Chronic heart failure (CHF) self-management for patients with severe physical and mental co-morbidities
Ciclesonide for chronic asthma in adults and children
Clinical and cost-effectiveness of depot and similar preparations of both conventional and atypical
antipsychotics for schizophrenia
Clinical- and cost-effectiveness of mid-urethral tape procedures in the first-line treatment of stress urinary incontinence.
Clinical and cost-effectiveness of monitoring the physical health of people with schizophrenia
Clinical and cost-effectiveness of pelvic floor muscle training in the first-line treatment of stress urinary incontinence
Clinical and economic benefits of cryotherapy compared to standard therapies for the primary treatment of localised prostate cancer
Clinical effectiveness, cost effectiveness and safety of DPP-4 inhibitors, compared with current UK practice or other newer agents, for the long-term management of blood glucose control in people with type 2 diabetes
Clinical effectiveness, cost effectiveness and safety of GLP-1 mimetics (with or without insulin), compared with standard UK practice or other newer agents, for the long-term management of blood glucose control in people with type 2 diabetes
Clinical efficacy and acceptability of combined antipsychotics (including clozapine) for schizophrenia when monotherapy has proved unsatisfactory
Clinical, cost and occupational effectiveness of Supported Employment in the UK for schizophrenia
Clinical, economic, quality of life, self-esteem and occupational effectiveness of supported employment for people with schizophrenia
Clinical, social and economic outcomes, including quality of life and the methods and effects of risk monitoring, of treatment by acute day hospitals, assertive outreach teams, in-patient units, and crisis resolution and home treatment teams
Clobazam versus other add-on treatments in the management of refractory epilepsy
Closed suction surgical wound drainage after hip fracture surgery
Closure versus non–closure of the peritoneum at caesarean section
Clotiapine for schizophrenia
Clotiapine for schizophrenia
Clozapine against other atypicals for treatment-resistant schizophrenia
Clozapine combined with different antipsychotic drugs for treatment resistant schizophrenia.
Clozapine to reduce hostility, violence and suicide for people with schizophrenia
Coal tar plus phototherapy (including Goeckerman regime) for psoriasis
Coblation versus other surgical procedures for tonsillectomy
Coenzyme Q10 for Parkinson's disease
Cognitive behaviour therapy versus specific pharmacological treatments for schizophrenia
Cognitive behaviour therapy versus standard care for schizophrenia
Cognitive Behavioural Therapy (CBT) for schizophrenia
Cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment resistant depression in primary care: a randomised controlled trial
Cognitive Behavioural Therapy for borderline personality disorder
Cognitive behavioural therapy for men who physically abuse their female partner
Cognitive behavioural therapy for migrainous vertigo
Cognitive Behavioural Therapy in the first episode of schizophrenia and those at risk of relapse
Cognitive reframing for carers of people with dementia
Cognitive rehabilitation (for domains other than memory and learning) in multiple sclerosis
Cognitive rehabilitation in patients with aquired brain injury
Cognitive stimulation and acetylcholinesterase inhibitors for Alzheimer’s disease over six months
Cognitive stimulation or acetylcholinesterase inhibitors for Alzheimer’s disease over six months
Colchicine for primary biliary cirrhosis
Collaborative care for depression and anxiety problems in primary care
Colloids versus crystalloids for fluid resuscitation in critically ill patients
Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia
Colorectal stents for the management of malignant colonic obstructions
Combinant therapy for seizure control in neonatal seizures
Combination inhaled steroid and long-acting beta2-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease
Combination inhalers as single treatment for asthma compared to standard therapy
Combination pharmacological and weight-loss therapy for non-alcoholic fatty liver disease
Combination therapies in hepatitis B patients with decompensated cirrhosis
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Combination therapy of heparin and graded compression stockings versus heparin alone for prevention of fatal pulmonary embolism in colorectal surgery
Combination therapy with newer nucleoside analogues for chronic hepatitis B
Combined corticosteroid and longacting bronchodilator in one inhaler for chronic asthma
Combined corticosteroid and longacting bronchodilator in one inhaler for chronic asthma
Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccine for primary prevention of hepatitis B
Combined split-thickness/suction grafts for repigmentation in vitiligo
Combined vestibular rehabilitation and cognitive behavioural treatment of chronic dizziness
Combining antipsychotics to treat schizophrenia that has proved to be poorly responsive to adequate trials of antipsychotic monotherapy
Combining presciption antidepressant drugs and psychological treatments for depression
Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children
Commercially available pelvic binder/splint compared to a circumferential sheet for immobilising/stabilising a pelvic trauma in the prehospital environment
Community mental health teams (CMHTs) for people with severe mental illnesses and disordered personality
Community Mental Health Teams trained to deliver specialist treatment, compared to specialist teams (e.g. Crisis Resolution, Home Treatment, and Early Intervention), for serious mental illness
Community wide interventions for increasing physical activity
Comparable effectiveness of therapies for unresectable recurrent and in-transit extremity melanoma.
Comparative effectiveness of different combined oral contraceptive pills for acne in women
Comparative efficacy of biological therapies for patients with psoriasis who fail to respond to conventional systemic treatments
Compared to a plaster on the buttock, is the therapeutic effect of an oestrogen plaster against menopausal symptoms on the stomach significantly higher?
Comparison of alternative therapies and progestagens and anti-progestagens for pain associated with endometriosis
Comparison of chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for patients with early unfavourable or advanced stage Hodgkin lymphoma
Comparison of different models of preconception counselling to reduce adverse pregnancy outcome in women with epilepsy
Comparison of luminal agents for use in conjuction with nitroimidazoles for eradication of Entamoeba histolytica from the intestine and for decreasing relapse
Comparison of short and long term treatment regimens for amoebic colitis
Comparison of the efficacy of different anti-TNF agents in Crohn's disease
Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women
Comparisons of outcomes from different packages of care for treatment of chronic pelvic pain in women
Complementary and alternative medicine in the treatment of sinusitis
Complementary and alternative therapies for acne
Complementary therapies for schizophrenia
Complementary therapies for schizophrenia
Complementary therapies in the management of childhood nocturnal enuresis
Complex behavioural interventions for nocturnal enuresis in children
Complex interventions for preventing diabetic foot ulceration
Compliance therapy for schizophrenia
Comprehensive exercise interventions for multiple sclerosis
Comprehensive geriatric assessment for older adults admitted to hospital
Compression stockings for the initial treatment of varicose veins in patients without venous ulceration
Compulsory community and involuntary outpatient treatment for people with severe mental disorders
Computer-assisted versus oral-and-written dietary history taking for diabetes mellitus
Computer-assisted versus oral-and-written family history taking for identifying people with elevated risk of type 2 diabetes mellitus
Concomitant adalimumab and other immunosuppressants for induction and maintenance of remission in Crohn's disease
Concomitant corticosteroids and adalimumab for induction and maintenance of remission in Crohn's disease
Concurrent chemoradiotherapy (alternative fractionation schedules) versus sequential chemoradiotherapy
Conservative compared to operative treatment for hip fractures in adults
Conservative management of acoustic neuroma
Conservative management of nocturia in adults
Conservative management such as pelvic floor muscle training for postprostatectomy urinary incontinence
Conservative treatment for middle third clavicle fractures in adolescents and adults
Conservative treatment for whiplash
Constraint-induced movement therapy of the upper limb in children with hemiplegic cerebral palsy
Consultation letters for medically unexplained physical symptoms in primary care
Containment strategies for people with serious mental illness
Continence care in the frail elderly.
Continence education programmes
Continuation and maintenance treatments for depressive disorder in older adults
Continuous glucose monitoring systems for type 1 diabetes mellitus
Continuous heparin infusion to prevent thrombosis and catheter occlusion in neonates with peripherally placed percutaneous central venous catheters
Continuous passive motion for preventing venous thromboembolism after total knee arthroplasty
Continuous subcutaneous insulin infusion compared with intensive insulin injections
Continuous support for women during childbirth.
Continuous versus intermittent renal replacement therapy for patients with acute kidney injury
Contralateral bone anchored hearing aids in acquired unilateral sensorineural hearing loss in adults
Control of humidity and excessive heat in the home for preventing or reducing the severity of atopic eczema
Conventional occlusion versus pharmacologic penalization for amblyopia
Cooling for cerebral protection during brain surgery
Corticosteroid injection for de Quervain's tenosynovitis
Corticosteroid injections compared to splinting or surgery for trigger finger in adults
Corticosteroids for acute bacterial meningitis
Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy
Corticosteroids for pneumonia
Corticosteroids for the treatment of chronic asthma in adults and children aged 12 years and over
Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis)
Corticosteroids for treating nerve damage in leprosy
Corticosteroids for treating optic neuritis
Corticosteroids for viral myocarditis
Corticosteroids used in addition to antiviral drugs in patients with Ramsay Hunt syndrome
Cost-effectiveness analysis of mesalamine for prevention of post-operative recurrence of Crohn's disease
Cost-effectiveness of clobazam versus newer anti-epileptic drugs
Cost-effectiveness of the newest anti-epileptic drugs as first line therapy
Costs and benefits of preconception counselling of women with epilepsy to healthcare organisations
Costs and benefits of preconception counselling to women with epilepsy
Cot-nursing versus incubator care for preterm infants
Cotrimoxazole for the prevention of diarrhoea in children with HIV infection or exposure to maternal HIV infection
Covered versus uncovered metal palliative biliary stents for obstructing pancreatic carcinoma
Creatine and creatine analogues in hypertension and cardiovascular disease
Creatine for treating muscle disorders
Crisis intervention for people with severe mental illnesses
Critical incident audit and feedback to improve perinatal and maternal mortality and morbidity
Cross-modal supplementation for tinnitus
Cryotherapy for hepatocellular carcinoma
Customised versus population-based growth charts as a screening tool for detecting small for gestational age infants in low-risk pregnant women
Custom-made foot orthoses for the treatment of foot pain
Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis
Cyclophosphamides for multifocal motor neuropathy
Cyclosporin A for primary biliary cirrhosis
Daclizumab for relapsing remitting multiple sclerosis
Danazol for pelvic pain associated with endometriosis
Dance/movement therapy for improving psychological and physical outcomes in cancer patients
Day centres for severe mental illness
Day hospital versus admission for acute psychiatric disorders
Debridement for surgical wounds
Decision aids and the effect on choice for surgery and knowledge of treatment options for breast cancer patients
Decompressive surgery for treating nerve damage in leprosy
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children for acute sinusitis in children
De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
Dehydroepiandrosterone (DHEA) for systemic lupus erythematosus
Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants
Delivery methods of education for people with type 2 diabetes.
Delivery of inhaled steroids in children - which is the most effective method of delivering drugs for asthmatic children?
Dental surgery for patients on anticoagulant therapy with warfarin
Depigmentation for improved quality of life in severe vitiligo
Depot/long-acting injectable antipsychotic preparations for schizophrenia
Dermofasciectomy for Dupuytren’s contractures of the hand
Desensitisation therapy (allergen-specific immunotherapy) for atopic eczema
Desmopressin plus enuresis alarm for nocturnal enuresis
Desmopressin to decrease blood loss and blood transfusion requirements for liver resection
Deterioration in the home of a person with asthma — action by patient including when to call for GP, when to self-admit
Determine the long-term effects of prompted voiding on daytime urinary incontinence in nursing home residents and homebound frail older adults
Dextrose for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Diagnosis of gestational diabetes
Diet and dietary supplements for schizophrenia
Dietary antioxidants and primary prevention of age related macular degeneration
Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Dietary interventions for rheumatoid arthritis
Dietary sodium manipulation and asthma
Dietary sodium modification on asthma control
Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy
Different antibiotic treatments for group A streptococcal pharyngitis
Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease
Different intensities of glycaemic control for pregnant women with pre-existing diabetes
Different methods of vascular occlusion for elective liver resection
Different referral patterns in primary care for the urinary incontinence patient
Different strategies for diagnosing gestational diabetes to improve maternal and infant health
Different types of alarm in the managment of childhood nocurnal enuresis
Different types of practitioners and treatment response to acupuncture for migraine prophylaxis
Differential effects of D-hormone analogs and native vitamin D on falls
Differing dose of normobaric and hyperbaric oxygen therapy combined with other therapies for migraine and cluster headache
Direct comparisons between atypical antipsychotics for schizophrenia
Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous thromboembolism following total hip or knee replacement
Dissection versus diathermy for tonsillectomy
Dithranol plus PUVA for psoriasis
Diuretics for heart failure
Diuretics for Ménière's disease or syndrome
DMARDs for rheumatoid arthritis
Do adults with psoriasis and psoriatic arthritis who use topical therapies who see non-medical healthcare professional have different outcomes on the Psoriasis Area and Severity Index (PASI) and service use?
Do alterations in diet help in asthma?
Do alternative / complementary treatments such as psychological techniques help in asthma?
Do antipsychotic drugs cause permanent physical adverse effects?
Do antipsychotic drugs make learning difficult?
Do anti-TNFs increase the risk of lymphoma in rheumatoid arthritis patients?
Do automated/mechanical chest compression devices improve survival in adult out-of-hospital cardiac arrest?
Do bisphosphonates increase the risk of atrial fibrillation?
Do breathing exercises help in asthma?
Do breathing exercises help in asthma?
Do calcium channel blockers prevent acute tubular necrosis (ATN) in cadaveric kidney transplant recipients?
Do certain antiepileptic drugs affect thyroid function?
Do certain antiepileptic drugs lead to clustering of seizures?
Do cleansers reduce acne severity?
Do combination inhalers taken for asthma cause osteoporosis with long term use?
Do combined exercise and self-management programmes reduce pain and increase function in community-based patients with knee and hip osteoarthritis?
Do continuous insulin infusion pumps offer an advantage over traditional intermittent insulin injections in terms of pregnancy outcomes in women with type 1 diabetes?
Do corticosteroids for asthma in children cause excess weight gain?
Do Crisis or Outreach teams prevent relapse of psychosis?
Do different insulin delivery systems allow me to make different lifestyle choices about diet and exercise
Do different propellants in inhalers for asthma predispose to migraine headaches?
Do epilepsy medications affect memory in the long term?
Do epilepsy medications affect the liver in the long term?
Do epilepsy medications cause impotence?
Do epilepsy medications cause shaking limbs?
Do fitness regimens have adverse effects on asthma?
Do foot orthotics have any structural or functional effect on hip and knee osteoarthritis?
Do herbal medicines prevent asthma attacks?
Do high plasma levels of trimethylamine (TMAO) gut flora metabolism of phosphatidylcholine cause cardiovascular disease?
Do homeopathic remedies help control asthma symptoms?
Do house dust mites cause atopic eczema?
Do I have to take asthma control treatment every day even when I am feeling fine?
Do I need to take my preventer inhaler for asthma every day?
Do I really need to use the asthma preventer every day?
Do individual metabolic differences influence outcomes treatment in schizophrenia? In what way?
Do individuals with erythromycin/clindamycin resistant propionibacterial floras respond adequately when erythromycin or clindamycin are used without concomitant benzoyl peroxide?
Do inhaled corticosteroids for asthma predispose one to diabetes?
Do inhaled steroids taken for asthama cause weight gain?
Do inhaled streroids for asthma cause lichen planus or lupus of the gums?
Do inhalers for asthma affect teeth?
Do interventions such as educating school staff help children with diabetes live a less restricted life during school time?
Do long acting insulin analogues maintain glucose control better than NPH insulin in the long term?
Do low dose oral antibiotics with good lipophilic properties lead to adequate clinical efficacy through anti-inflammatory rather than anti-microbial action and in turn reduce likelihood of resistance emerging?
Do multi-dose insulin injection regimes adversely affect the quality of life of [i] children and adolescents and [ii] adults with Type 1 diabetes?
Do Omega 3 supplements alleviate psychotic symptoms?
Do patient/public and health professionals' views of urinary incontinence effect continence status?
Do patients who are withdrawing from olanzapine, taken for schizophrenia, experience withdrawal symptoms after more than 5 years of treatment?
Do people who have a first seizure need to see an epilepsy specialist for treatment?
Do phosphodiesterase inhibitors help women with diabetes mellitus who have sexual dysfunction?
Do phosphodiesterase inhibitors improve erectile dysfunction in people with uncontrolled diabetes mellitus?
Do preventer inhalers with steroids have to be used every day for children with asthma?
Do preventer inhalers with steroids have to be used every day for children with asthma?
Do probiotics significantly reduce trimethylaminuria (TMAU1) producing bacteria in the human intestine and does this result in clinically relevant decreases in TMA production, and thus body odour, in patients with TMAU1?
Do psychological interventions improve arthritis pain management?
Do psychological therapies decrease dependence on standard medication and promote full recovery in severe mental illness?
Do psychological therapies decrease relapse and re-hospitalizations in patients with severe mental illness?
Do rituximab or abatacept for rheumatoid arthritis increase the risk of infection?
Do side effects to a certain anti-epileptic medication help predict side effects to other anti-epileptic medications?
Do some antiepileptic drugs cause auras?
Do spacers work as well as nebulisers in severe asthma attacks?
Do steroid inhalers taken for asthma cause osteoporosis?
Do steroids lose any effectiveness used over a long period of time for asthma?
Do steroids taken for asthma cause osteoporosis in later life?
Do the adverse effects of antipsychotic drugs outweigh the benefits?
Do the long acting insulin analogues improve diabetes complications better than NPH insulin in the long term?
Do the meglitinide analogues reduce the morbidity and mortality from diabetes associated complications?
Do the newer antiepileptic drugs cause low bone mineral density?
Do treatments other than medication help asthma symptoms?
Do uterine fibroids cause infertility and should they be removed to increase fertility?
Do variations in GP awareness of prostate cancer affect outcomes?
Do you have different daily water requirements if you are taking epilepsy medication?
Does a combination of albuterol and Benadryl relieve distress in people who are thought to have food "intolerance's" and asthma?
Does a high carbohydrate diet and the subsequent increased daily dose of insulin lead to more frequent and/or more severe hypoglycaemia in people with Type 1 diabetes?
Does a high carbohydrate diet cause weight increase in Type 1 and Type 2 diabetes
Does active pituitary monitoring post traumatic brain injury for children improve outcomes?
Does active surveillance work for treatment of prostate cancer?
Does activity scheduling and physical exercise increase well being of patients with schizophrenia?
Does acupuncture help in asthma?
Does acupuncture produce analgesia and is any or all of this a placebo effect?
Does acupuncture reduce the need for inhaled steroids in asthma?
Does Advair Diskus 500/50 taken for asthma cause musculoskeletal pain?
Does advice to parents for children with asthma on allergen avoidance help avoid asthma attacks?
Does allergen avoidance work in asthma?
Does anti-cyclic citrullinated peptide guide the management of patients with early rheumatoid arthritis?
Does avoidance of contact with animals reduce asthma severity?
Does avoidance of peanuts in early life reduce the risk of peanut allergy?
Does avoiding certain foods help to control asthma in children?
Does avoiding triggers help my asthma?
Does belonging to a religious movement help my schizophrenia?
Does Benfotiamine (form of Vit B1) prevent diabetes complications?
Does breastfeeding protect against allergic rhinitis during childhood?
Does breathing air through a salt pipe help to control asthma symptoms?
Does change of environment for a person affect the prevalence of asthma?
Does changing geographical locations to a warmer climate help with asthma?
Does continuous glucose monitoring in diabetes yield better self-management?
Does delayed diagnosis and thus treatment of pernicious anaemia cause people to develop adverse effects such as peripheral neuropathy or sub-acute combined degeneration of the spinal cord?
Does early aggressive treatment at the first signs of acne alter the natural history of disease and reduce the need for further systemic therapy?
Does ECT for depression cause memory loss?
Does ECT for schizophrenai cause memory loss?
Does effective intranasal corticosteroid treatment of rhinitis reduce asthma exacerbations and costs?
Does family therapy for schizophrenia reduce relapse?
Does having a stoma (in a patient with Crohn's disease) cause drowsiness?
Does having to pay for asthma prescriptions reduce the effectiveness of treatment in controlling asthma?
Does home oxygen benefit people with chronic heart failure?
Does homeopathy help in asthma?
Does hyperventilating help reduce asthma symptoms?
Does identification of microalbuminuria during pregnancy offer the opportunity for appropriate pharmacological treatment to prevent progression to pre-eclampsia in women with pre-existing diabetes?
Does investigation of possible allergies improve the treatment of asthma?
Does involvement of parents in the care plan improve the care of children with diabetes?
Does long term use of steroids for asthma increase the risk of arteriosclerosis?
Does long-term low-dose trimethoprim promote wound healing in patients with severe forms of epidermolysis bullosa and how well is low dose trimethoprim tolerated?
Does memantine reduce progression of functional disability in people with severe vascular dementia?
Does methotrexate monotherapy increase the risk of malignancy in rheumatoid arthritis?
Does mild renal impairment get worse if a person takes lithium for mood disorders?
Does moving to a sunnier climate help asthma?
Does not having to pay for prescription medication for chronic asthma help improve symptoms?
Does not paying for medication for asthma increase compliance?
Does poly-pharmacy in older patients with severe mental illness cause greater adverse events?
Does prehospital ultrasound improve survival of the trauma patient?
Does primary chemo-irradiation improve loco-regional control and overall survival? squamous cell carcinoma of the Head & Neck and for which specific anatomical sites?
Does psychodynamic therapy really make a difference to symptoms, functioning and quality of life of people with schizophrenia?
Does reducing glucose variability reduce long term complications of type 1 diabetes even when average levels are not reduced?
Does regular use of emollients reduce disease relapse in atopic eczema?
Does removal of pets influence disease activity in established atopic eczema?
Does risperidone worsen psoriasis?
Does routine review of people with asthma improve outcome?
Does salbutamol used to treat asthma cause cramps?
Does self-management education for children with epilepsy change seizure frequency?
Does Seretide affect pregnancy?
Does serial PSA measurement in patients with prostate cancer accurately monitor disease progression?
Does setting national targets for blood glucose levels discourage health professionals setting targets according to individual needs/situations?
Does sleep or the lack of sleep affect the way your epilepsy medication works
Does social support in the early acute phase of schizophrenia help reduce relapse?
Does staff training in cultural competence at an individual and organisational level improve the experience of care and chance of recovery from schizophrenia in Black and Minority Ethnic groups, and reduce staff burnout?
Does statin use reduce the risk of hip fracture?
Does strontium ranelate increase vascular and neurological side-effects in postmenopausal osteoporosis?
Does sunlight exposure reduce acne severity?
Does switching from brand-name to generic antiepileptic epilepsy drugs increase risk of seizures?
Does systemic HRT use in women whose primary complaint was not urinary incontinence worsen urinary symptoms?
Does taking steroids for asthma cause depression, or add to feeling depressed?
Does taking steroids for asthma stop me losing weight?
Does taking steroids for asthma stop me losing weight?
Does Tegretol cause balance problem in schizophrenia?
Does testing for allergies lead to better treatment for children with asthma?
Does the addition of counters to inhalers for asthma improve use by the patient?
Does the addition of psychological interventions (e.g. counselling, support) to patients receiving cosmetic camouflage improve their quality of life?
Does the addition of the oral agent metformin to insulin treatment in children and young people with type 1 diabetes improve outcomes?
Does the addition of zinc to topical erythromycin confer additional benefit in the treatment of acne?
Does the management of co-existing neck problems improve outcomes for patients with balance disorders?
Does the method of insulin delivery (injection vs. pump) have any impact on rates of complications?
Does the pain of blood glucose testing affect the willingness of patients, especially children, to monitor their blood glucose levels?
Does the way information is provided to patients with mental health conditions effect the outcome of treatment?
Does TNF-blockade therapy exacerbate psoriatic arthritis?
Does tooth brushing influence the development and progression of non-inflammatory gingival recession?
Does treatment for stress and panic reduce asthma attacks?
Does treatment of periodontal disease improve glycaemic control in people with diabetes?
Does treatment of type 1 diabetics by specialists (e.g. doctors, nurses, dieticians, podiatrists, ophthalmologists and psychologists) trained in person-centred skills provide better blood glucose control, patient satisfaction and self-confidence in management of type 1 diabetes, compared to treatment by non specialists with standard skills?
Does treatment with immunosuppressants help patients with vitiligo?
Does under treatment of pernicious anaemia cause cyclic cognitive impairment for patients?
Does unopposed oestrogen therapy have a protective effect against osteoarthritis?
Does using inhalers for asthma cause acid indigestion?
Does variation in treatment for patients with psychosis, which is often trail and error, affect compliance?
Does Yoga help in asthma?
Dopamine agonists for restless legs syndrome
Dopamine versus placebo for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Dopexamine versus placebo for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Dosages scheduling of taxanes and the optimal use of taxanes in early breast cancer
Dose regimens, length of treatment, and duration of response of oestrogen and progesterone add-back therapy in preventing bone mineral density loss in patients taking gonadotrophin-releasing hormone analogues for endometriosis
Doses and administration routes for individual triptans and acute cluster headaches
Doxycycline for hip or knee osteoarthritis
Drama therapy for schizophrenia or schizophrenia-like illnesses
DRCgs for treating paracoccidioidomycosis
Dressings for the prevention of surgical site infection
Driving is a risk in patients with sleep-related epilepsy
Drug therapy for nocturia
Drug therapy for the management of cancer related fatigue
Drug therapy for treating post-dural puncture headache
Drug treatment for nocturnal enuresis
Drug treatment for troublesome postural hypotension in people with diabetes and autonomic neuropathy
Drugs and pacemakers for vasovagal, carotid sinus and situational syncope
Drugs for amoebic colitis
Drugs for nocturia in adults
Drugs to treat urinary incontinence in the elderly
Dry bed training for nocturnal enuresis
Duloxetine depression
Dynamic exercise programs (aerobic capacity and/or muscle strength training) in rheumatoid arthritis
Ear drops for the removal of ear wax
Early (sentinel lymph node biopsy-guided) versus delayed lymphadenectomy in melanoma patients with lymph node metastases
Early additional food and fluids for healthy breastfed full-term infant
Early compared with delayed oral fluids and food after caesarean section
Early intervention with oral isotretinoin versus alternative treatments for moderate or mild acne
Early prediction of outcome of activities of daily living after stroke
Early removal versus expectant management of central venous catheters in neonates with bloodstream infection
Early treatment of preclinical hypothyroidism
Early versus delayed refeeding for children with acute diarrhoea
ECT for schizophrenia
Edaravone for acute intracerebral haemorrhage
Edaravone for acute ischaemic stroke
Education interventions for adults who attend the emergency room for acute asthma
Educational interventions for asthma in adults
Efavirenz or nevirapine in three-drug combination therapy with two nucleoside-reverse transcriptase inhibitors for initial treatment of HIV infection in antiretroviral-naive individuals
Effect of duration (3 vs. 6 months) of long-term pituitary down-regulation before in vitro fertilisation for women with endometriosis on pregnancy rates
Effect of gastric banding on gastro-oesophageal reflux symptoms
Effect of lip bumpers on mandibular arch dimensions
Effect of near vision tasks on visual acuity in children with amblyopia
Effect of phenytoin and phenobarbital on bone mineral density in children
Effect of steroidal contraceptives on bone fractures in women
Effective interventions for managing physical health of people with schizophrenia in general practice
Effective interventions for preventing and treating kidney disease in Henoch-Schonlein Purpura (HSP)
Effective interventions for preventing infection in nephrotic syndrome
Effective interventions for primary vesicoureteric reflux
Effective interventions to prevent bone disease in kidney transplant recipients
Effective methods of communication at first consultation visit for women with breast cancer?
Effective physical interventions to treat depression in dialysis patients
Effective psychosocial interventions to treat depression in dialysis patients
Effective treatments for truncal acne
Effectiveness and acceptability of interventions for moist desquamation in radiotherapy patients
Effectiveness and impact of consumer education initiatives for urinary incontinenece
Effectiveness of a second acupuncture treatment in improving migraine
Effectiveness of debridement of diabetic foot ulcers
Effectiveness of different types of acupuncture for migraine prophylaxis
Effectiveness of early in comparison to late(r) treatment in children with amblyopia or its risk factors
Effectiveness of external inspection of compliance with standards in improving healthcare organisation behaviour, healthcare professional behaviour or patient outcomes
Effectiveness of lower-dose combined oral contraceptives in women with IBD following bowel resection
Effectiveness of the various components of preconception counselling to reduce adverse pregnancy outcome in women with epilepsy
Effectiveness of topical administration of opioids in palliative care
Effects and safety of periconceptional folate supplementation for preventing birth defects
Effects of etanercept on malignancy for rheumatoid arthritis
Effects of hormonal suppression, either before or after surgery, on endometriosis-associated pain and disease severity
Effects of long acting inhaled anticholinergics on cardiovascular events and mortality among vulnerable subgroups at the highest risk of systemic anticholinergic effects
Effects of long term pituitary down-regulation using GnRH agonists before in vitro fertilisation in women with endometriosis on the incidence of fetal abnormalities
Effects of long term pituitary down-regulation using GnRH agonists before in vitro fertilisation in women with endometriosis on the rate of multiple pregnancy
Efficacy and safety of Chinese herbal therapies for atopic eczema
Efficacy and safety of coal tar for chronic plaque psoriasis
Efficacy and safety of Grenz rays for psoriasis
Efficacy and safety of home UVB therapy for psoriasis compared to treatment in hospital
Efficacy and safety of intravenous immunoglobulin for atopic eczema, especially in patients who are not resistant to other systemic treatments
Efficacy and safety of leflunomide for atopic eczema
Efficacy and safety of leukotriene inhibitors (anti-leukotrienes) for atopic eczema
Efficacy and safety of methotrexate for atopic eczema
Efficacy and safety of oral mycophenolate mofetil for atopic eczema
Efficacy and safety of photodynamic therapy for acne
Efficacy and safety of wet-wraps for long-term treatment of atopic eczema
Efficacy of dental prophylaxis (rubber cup) for the prevention of caries and gingivitis
Efficacy of directional-microphone hearing aids
Efficacy of dithranol compared to topical vitamin D preparations (calcipotriol, calcitriol, tacalcitol) for chronic plaque psoriasis
Efficacy of emollients for chronic plaque psoriasis
Efficacy of intranasal corticosteroids for acute sinusitis
Efficacy of programmable analog hearing aids
Efficacy of retinoids in the treatment of psoriasis
Efficacy of topical salicylic acid for chronic plaque psoriasis
Efficacy, tolerability, and safety of extended-release, topical, and novel anti-muscarinic agents for urinary incontinence in frail and institutionalised older people
Efficacy, tolerability, and safety of medications used to prevent urinary incontinence for extended periods (beyond 6 months)
Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia
Elastic compression stocking for prevention of deep vein thrombosis
Elective surgery versus clinical observation for focal liver lesions incidentally detected and supposed to be benign
Electrical stimulation with non-implanted electrodes for urinary incontinence in adults
Electroconvulsive therapy (ECT) for schizophrenia
Electroconvulsive therapy for the depressed elderly
Electromagnetic field stimulation for treating delayed union or non-union of long bone fractures in adults
Electromagnetic therapy for treating venous leg ulcers
Electromagnetic treatment for urinary incontinence in adults
Electropalatography for articulation disorders associated with cleft palate
Electrotherapy for neck pain
Elemene for the treatment for lung cancer
Endorectal advancement flap vs. other surgical techniques for cryptoglandular or Crohn's fistula-in-ano
Endoscopic or surgical intervention for painful obstructive chronic pancreatitis
Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy
Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus conventional surgery for great saphenous vein varices
Energy source instruments for laparoscopic colectomy
Enhanced external counterpulsation
Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy
Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy
Environmental change for preventing asthma
Environmental enrichment for schizophrenia
Enzyme replacement therapy for trimethylaminuria (odour problems)
Enzyme replacement therapy with idursulfase for mucopolysaccharidosis type II (Hunter syndrome)
Epidermal growth factor receptor blockers for the treatment of ovarian cancer
Epidermal growth factor receptor targeted therapy in locally advanced head and neck squamous cell carcinoma
Epidural blood patching for preventing and treating post–dural puncture headache
Epinephrine for the resuscitation of apparently stillborn or extremely bradycardic newborn infants
Ergonomic positioning or equipment for treating carpal tunnel syndrome
ER-Yag laser plus topical 5-fluorouracil preceding narrow band UVB phototherapy for repigmentation in vitiligo
Erythropoietin and Darbepoetin for patients with malignant disease
Escitalopram versus other antidepressive agents for depression
Eslicarbazepine acetate add-on for drug-resistant partial epilepsy
Ethnically specific and specialist services for people with schizophrenia
Etidronate and risk of upper gastrointestinal injury in osteoporotic fractures
Evening Primrose oil for schizophrenia
Evening versus morning dosing regimen drug therapy for hypertension
Excitatory amino acid antagonists for acute stroke
Exclusion diets for irritable bowel syndrome
Exclusion diets for preventing atopic eczema in infants at high risk for the development of atopy
Exclusion diets for treating established atopic eczema
Exclusive breast-feeding for preventing atopic eczema in infants at high risk for the development of atopy
Exercise based rehabilitation for heart failure
Exercise for acutely hospitalised older medical patients
Exercise for depression
Exercise for fibromyalgia syndrome
Exercise for improving cardiovascular status in rheumatoid arthritis
Exercise for non-alcoholic fatty liver disease
Exercise for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Exercise for older depressed people
Exercise for preventing low bone mineral density in children with juvenile rheumatoid arthritis
Exercise for the management of ACL injuries in combination with collatoral ligament and meniscal damage
Exercise for the management of cancer-related fatigue in adults
Exercise in depression
Exercise prescriptions' as a treatment for depression
Exercise therapy for schizophrenia
Exercise training for adults with chronic kidney disease
External counterpulsation for acute ischaemic stroke
External fixation methods for treating distal radial fractures in adults
Extra-urethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence
Face-down positioning or posturing after macular hole surgery
Facial aesthetics: is botulinum toxin treatment effective and safe?
Factors associated with non-adherence to oral medication for inflammatory bowel disease
Factors influencing the regular use of prophylactic medication for those with asthma.
Famciclovir and other new antiviral agents for preventing postherpetic neuralgia
Family interventions for the families of people with schizophrenia presenting for the first time
Family therapy for depression
Family therapy for schizophrenia
Fast track surgery versus conventional recovery strategies for colorectal surgery
Feedback or biofeedback to augment pelvic floor muscle training for urinary incontinence in women
Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate
Fetal manipulation for facilitating tests of fetal wellbeing
Fibrinolytic therapy for intraventricular hemorrhage in adults
First trimester progesterone prophylaxis to increase the live birth rate in women with unexplained recurrent miscarriages
Fish oil for schizophrenia
Fish oil supplementation for psoriasis
Flossing for the management of periodontal diseases and dental caries in adults
Fluid restriction and prophylactic indomethacin versus prophylactic indomethacin alone for prevention of morbidity and mortality in extremely low birth weight infants
Fluid therapy for acute bacterial meningitis
Flunisolide for chronic asthma
Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children
Fluoxetine for depression
Flutamide for treatment of acne in women
Fluticasone versus HFA-beclomethasone dipropionate for chronic asthma in adults and children
Fluvoxamine for depression
Foam dressings for healing diabetic foot ulcers
Foetal safety of nasal decongestants as second line therapy for pregnant women with allergic rhinitis
Folate Augmentation of Treatment - Evaluation for Depression: randomised controlled trial (FolATED)
Folic acid for fragile X syndrome
Folic or folinic acid supplementation for preventing methotrexate-associated haematological side-effects in inflammatory disease
Follicular flushing during oocyte retrieval in assisted reproductive techniques
Follow-up strategies for patients treated for non-metastatic colorectal cancer
For an acute exacerbation of asthma, a patient has taken 150mg prednisolone per day for 1 week, and is now slowly being weaned off. Is there any information on acute or long term damage?
For patients with oral cancer and a clinically N0 neck undergoing surgery to the primary site, in which circumstances is it beneficial to carry out a simultaneous prophylactic neck dissection.
For women with a high risk pregnancy, does taking marine oil supplements prolong gestation?
For women with high blood pressure during pregnancy, what are the benefits and risks of rest in hospital compared with rest at home?
For women with high blood pressure during pregnancy, what are the short and long term effects of antihypertensive drugs for both the mother and the child?
For women with normal blood pressure during pregnancy, does rest help prevent pre-eclampsia and its complications?
For women with pre-eclampsia complicated by HELLP (Haemolysis, Elevated Liver enzymes, and Low Platelets) syndrome, is treatment with steroids beneficial?
For women with pre-eclampsia, does Chinese herbal medicine prevent complications, and is it safe?
For women with raised blood pressure during pregnancy, at what level of blood pressure does antihypertensive medication become worthwhile?
For women with raised blood pressure during pregnancy, what are the advantages and disadvantages of wearing a device to measure blood pressure over a period of time, usually 24 hours, compared to conventional measuring of blood pressure in clinic?
For women with troublesome fibroids who wish to retain or enhance their fertility, is myomectomy or embolisation better?
Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma
Fortifying food with calcium during pregnancy, rather than taking calcium tablets to prevent pre-eclampsia.
Framing of health information messages
Frequency modulation (FM) system in auditory processing disorder
Fresh frozen femoral head allograft compared to processed femoral head allograft in revision hip arthroplasty
Functional electrical stimulation (FES) versus conventional aerobic exercise (CA) in chronic heart failure (CHF) patients
Functional endoscopic balloon dilation of sinus ostia for chronic rhinosinusitis
Functional endoscopic sinus surgery for chronic rhinosinusitis
Gabapentin add-on for drug-resistant partial epilepsy
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
Gamma nail or sliding hip screw for the treatment of intertrochanteric fracture
Garlic, or garlic preparations, to prevent pre-eclampsia and its complications.
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer
General physical health advice for people with serious mental illness
Genetic testing before anticoagulation
Ginkgo biloba extract for age-related macular degeneration
Ginkgo biloba for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Ginkgo biloba for tinnitus
Ginkgo special extract EGb 761® for vertigo
Ginseng for cognition
Glucagon-like peptide analogues for type 2 diabetes mellitus
Glucocorticoids for acute viral bronchiolitis in infants and young children
Glucocorticosteroids for alcoholic hepatitis
Glucocorticosteroids for primary sclerosing cholangitis
Glutamine supplementation for young infants with severe gastrointestinal disease
GnRH agonists or OCPs for symptom relief in women with endometriosis-associated pain
Gonadotrophin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction
Gonadotrophin-releasing hormone analogues for pain associated with endometriosis
GP-led melanoma follow up for improved patient satisfaction
Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections
Green tea for the prevention of gastrointestinal cancer
Growth hormone for in vitro fertilization
Habit retraining in the management of urinary incontinence
Haematological interventions for treating disseminated intravascular coagulation during pregnancy and postpartum
Haemodilution for acute ischaemic stroke
Haemodilution for retinal vein occlusion
Haemodilution to decrease blood loss and blood transfusion requirements for liver resection
Haemoglobin target in the treatment of anaemia associated with Chronic Kidney Disease
Haemostatic drugs for traumatic brain injury
Haloperidol versus chlorpromazine for schizophrenia
Harmonic scalpel versus other surgical procedures for tonsillectomy
Head massage for tinnitus
Health checks for people with intellectual disabilities to reduce morbidity and premature mortality
Heat therapies for acne
Helicobacter pylori eradication for Parkinson's disease
Hematopoietic stem cell transplantation for people with ?-thalassaemia major
Hemodilution to improve visual acuity in branch retinal vein occlusion
Hemodilution to improve visual acuity in central retinal vein occlusion
Heparin and related substances for preventing diabetic kidney disease
Hepatic late adverse effects after antineoplastic treatment for childhood cancer
Hepatic lymph nodes during resection of liver metastases from colorectal cancer
Hepatitis B vaccination during pregnancy for preventing infant infection
Hepatotoxic effects of acetaminophen in alcoholics when taken for more than a few days
Herbal and dietary therapies for primary and secondary dysmenorrhoea
Herbal interventions for allergic rhinitis
Herbal interventions for chronic asthma in adults and children
Herbal medications for Ménière's disease
Herbal medicines for the treatment of rhinosinusitis
Herbal remedies (including cannabis and cannabinoids) for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Herbal therapy for treating rheumatoid arthritis
High altitude therapy for asthma
High dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with early poor prognosis breast cancer
High dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with metastatic breast cancer
High dose versus low dose oxytocin for augmentation of delayed labour
High flow nasal cannula for respiratory support in preterm infants
High-carbohydrate, high-protein, low-fat versus low-carbohydrate, high-protein, high-fat enteral feeds for burns
High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma
High-dose dual therapy of omeprazole and amoxycillin for Helicobacter pylori eradication in patients with gastric MALT lymphoma
High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults
High-dose versus non-high-dose proton pump inhibitors for bleeding peptic ulcers in seriously ill patients
Hip protectors for preventing hip fractures in elderly nursing home residents
Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma
Holding chambers versus nebulisers for inhaled drugs in chronic asthma
Holding chambers versus nebulisers for inhaled steroids in chronic asthma
Home care by outreach nursing for chronic obstructive pulmonary disease
Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age
Home-based child development interventions for preschool children from socially disadvantaged families
Home-based educational interventions for children with asthma
Home-based physiotherapy interventions to reduce breathlessness during activities of daily living in severe COPD
Homeopathy for asthma
Homeopathy for atopic eczema
Homeopathy for Ménière's disease
Homeopathy for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Homeopathy in the treatment of allergic rhinitis
Honey and lozenges for children with non-specific cough
Hormonal therapy in advanced or recurrent endometrial cancer
Hormone replacement for osteoporosis in women with primary biliary cirrhosis
Hormone replacement therapy (HRT) following bilateral oophorectomy with or without hysterectomy in women with symptoms of endometriosis
Hospital at home: home-based end of life care
Hospital nurse staffing models and patient and staff-related outcomes
House dust mite control measures to control asthma symptoms
How accurate is positron emission tomography/computed tomography for identifying residual tumours in adults with testicular germ cell tumours?
How and when should immunosuppression in kidney transplant patients be reduced?
How beneficial is surgery for cervical radiculopathy and myelopathy?
How best to prepare people with diabetes for use of an insulin pump
How big a problem is non-alcoholic fatty liver disease?
How can awareness of and prevention of hypoglycaemia in type 1 diabetes be improved?
How can I lose weight when taking prednisolone for asthma?
How can I manage the effects of corticosteroids, which I take for asthma, on my voice, and what effect is it having in the long term?
How can insulin delivery devices, such as pens, be improved to display unambiguously that insulin has been delivered?
How can insulin dosage for type 1 diabetes best be adjusted around exercise and/or stress?
How can non-invasive, accurate, real-time Continuous Glucose Monitoring be achieved?
How can over-treatment for prostate cancer be prevented by indentifying and excluding the treatment of harmless tumours?
How can people identify which is the correct needle length for them when injecting insulin for diabetes?
How can the fetus at risk of intrauterine death be identified in women with diabetes?
How can we make doctors better aware of rare anti-epileptic drug side effects?
How critical is the timing of taking epilepsy medication?
How do anti-epileptic drugs affect personality?
How do COX-2 selective NSAIDs compare to non-selective NSAIDs for arthritis?
How do epilepsy medications affect communication skills?
How do epilepsy medications affect the stomach in the long term?
How do I choose which insulin pen is best for me?
How do I know if the inhaled steroids my child is prescribed for their asthma are being delivered in the right dose and if their technique is adequate?
How do I know when my asthma is bad enough to seek medical treatment and who should I go to?
How do I manage my asthma symptoms during my menstrual cycle?
How do rates of adherence differ with different complexities of treatment regimen for the management of type 2 diabetes?
How do tricyclics, duloxetine, glabapentin and pregabalin compare in their reduction of pain caused by diabetic neuropathy?
How do we get to the real story from people with type 1 diabetes presenting in clinic and how can we tell when they are wanting to or needing to present as compliant?
How do we improve adherence to oral antipsychotic drugs?
How do you get children with asthma to take their medication regularly?
How does natural sunlight interact with other treatments for vitiligo?
How does the initiation and titration of long-acting insulin affect health-related quality of life in patients with type 2 diabetes?
How does topical diclofenac compare with eltenac in osteoarthritis?
How does type of surgery and rehabilitation affect the outcome of anterior cruciate ligament injuries?
How early is early to give statins for people with diabetes?
How effective and safe are dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) for osteoarthritis?
How effective are alternative or complimentary therapies for nocturia?
How effective are antibiotics for trimethylaminuria?
How effective are anti-oxidants when combined with mitochondrial stimulating cream in treating vitiligo?
How effective are anti-oxidants when combined with tablets such as phenylalanine in treating vitiligo?
How effective are drug based therapies for nocturia?
How effective are herbal remedies in treating vitiligo?
How effective are hormones or hormone related substances that stimulate pigment cells (MSH analogues, afamelanotide) in treating vitiligo?
How effective are mobilsation strategies after hip fracture in adults?
How effective are other complementary therapies (e.g. aloe vera, UNANI) in treating vitiligo?
How effective are patellar taping and bracing for knee osteoarthritis?
How effective are psychological therapies and peer support groups for adults with psoriasis and psoriatic arthritis?
How effective are SAD light boxes in treating vitiligo?
How effective are steroid creams in treating vitiligo?
How effective are steroid tablets in treating vitiligo?
How effective are surgical interventions for overactive bladder?
How effective is a choline elimination diet for treating trimethylaminuria?
How effective is ambulatory continuous blood glucose monitoring in pregnancies complicated by diabetes?
How effective is cosmetic camouflage for the management of vitiligo?
How effective is cream containing Vitamin D analogues (calcipotriol and tacalcitol) in the treatment of vitiligo?
How effective is education into the use of cosmetic camouflage for the management of vitiligo?
How effective is electronic surveillance vs. observation of hand washing to check compliance?
How effective is hormone replacement therapy (HRT) in treating vitiligo?
How effective is laser therapy in treating vitiligo?
How effective is laser therapy when combined with creams or ointments (e.g. steroid cream) in treating vitiligo?
How effective is levamisole in treating vitiligo?
How effective is levamisole taken by mouth when combined with creams or ointments (e.g. steroid cream) in treating vitiligo?
How effective is melagenina in treating vitiligo?
How effective is micropigmentation in treating vitiligo?
How effective is natural sunlight in achieving repigmentation of the skin in patients with vitiligo?
How effective is nerve stimulation in treating vitiligo?
How effective is patient information in improving management, self care and adherence with treatment in patients with atopic eczema?
How effective is piperine (black pepper) cream in treating vitiligo?
How effective is piperine taken by mouth in treating vitiligo?
How effective is plant-based catalase/dismutase in treating vitiligo?
How effective is psoralen cream/ointment combined with exposure to natural sunlight (topical PUVAsol) in treating vitiligo?
How effective is psychosocial care for people with diabetes?
How effective is PUVA therapy in treating vitiligo?
How effective is PUVA therapy when combined with other creams and ointments in treating vitiligo?
How effective is PUVA therapy when combined with other medicines taken by mouth in treating vitiligo?
How effective is radiotherapy in localised versus widespread Post Transplant Lymphoproliferative Disorders?
How effective is skin grafting in treating vitiligo?
How effective is taking psoralen by mouth combined with exposure to natural sunlight (oral PUVAsol) in treating vitiligo?
How effective is the introduction of foreign bodies (such as intestinal worms) in treating vitiligo?
How effective is transvaginal ultrasound for the detection of congenital malformations in women with diabetes and coexisting obesity?
How effective is urinary diversion surgery for urinary incontinence for people with spina bifida?
How effective is using 72 hour blood glucose monitoring and educating individuals in the management of type 1 diabetes?
How effective is UVA light therapy in treating vitiligo?
How effective is UVA light therapy when combined with creams or ointments (e.g. khellin, lactic acid, steroid creams) in treating vitiligo?
How effective is UVA light therapy when combined with treatments taken by mouth (e.g. phenylalanine, khellin) in treating vitiligo?
How effective is UVB light therapy in treating vitiligo?
How effective is UVB light therapy when combined with creams or ointments (e.g. steroid creams) in treating vitiligo?
How effective is UVB light therapy when combined with medicines taken by mouth in treating vitiligo?
How effective is UVB light therapy when combined with the needling technique in treating vitiligo?
How effects on health equity are assessed in systematic reviews of interventions
How frequently should inhaler technique assessment be performed for someone with asthma?
How is inhaler technique best assessed for someone with asthma?
How long should a course of antibiotic treatment be for acne?
How many doses of reliever can be given safely to a child showing signs of an impending asthma attack?
How many times can you use the same syringe to inject insulin?
How might acne relapses be best treated?
How much will treating psychological distress, including depression and anxiety in adults with psoriasis and psoriatic arthritis have an effect on disease severity and flare-ups?
How much alcohol is safe to consume while taking epilepsy medication?
How much do psychological interventions (such as counselling) help people with vitiligo?
How much is too much medication to use of the preventer medicine when breathing difficulty does not go away over several hours?
How much symptom relief occurs in women taking Pentoxifylline for the treatment of endometriosis?
How often should blood pressure be measured in healthy pregnant women and when is the best time to do this?
How reliable is first-trimester screening for Down’s syndrome incorporating levels of pregnancy associated plasma protein (PAPP-A) in women with pre-existing diabetes?
How safe is acupuncture for knee osteoarthritis?
How safe is it for my baby if I am breastfeeding and taking antidepressant medication?
How safe is pseudocatalase cream combined with UVB light therapy in treating vitiligo?
How safe is PUVA therapy in treating vitiligo?
How safe is skin grafting in treating vitiligo?
How safe is UVA light therapy in treating vitiligo?
How safe is UVB light therapy in treating vitiligo?
How satisfied are patients with schizophrenia with the drug they take for their illness
How should healthcare professionals balance the treatment needs of children with the involvement of parents?
How should I decide whether to nebulise again following an asthma attack, or go to hospital?
How should I manage my asthma when I have a cold?
How should I take my epilepsy medication when I have a stomach upset?
How should you manage your epilepsy medication in new time zones?
How successful is surgery for epilepsy?
How tightly controlled do fluctuations in blood glucose levels need to be to reduce the risk of developing complications in people with type 1 diabetes?
How will Government / Clinical guidelines help my brittle asthma?
HTA study of antidepressants for depression in dementia - a definitive multicentre pragmatic randomised controlled trial of clinical and cost effectiveness (HTA-SADD)
Huangqi injection for patients with chronic heart failure
Human growth hormone during the active phase of intestinal adaptation in short bowel syndrome
Humidification of inspired air in exercise-induced asthma
Huperzine A for vascular dementia
Hyaluronate for temporomandibular joint disorders
Hydralazine/isosorbide dinitrate for heart failure
Hydrogel dressings for healing diabetic foot ulcers
Hydrotherapy for asthma
Hydroxyurea for psoriasis
Hydroxyzine for generalised anxiety disorder
Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa
Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus
Hyperbaric oxygen therapy (HBOT) for fracture healing
Hyperbaric oxygen therapy and eye disorders
Hyperbaric oxygen therapy and infertility
Hyperbaric oxygen therapy and sports injuries
Hyperbaric oxygen therapy and surgical site infection
Hyperbaric oxygen therapy and thermal burns
Hyperbaric oxygen therapy and urology
Hyperbaric oxygen therapy for acute coronary syndrome
Hyperbaric oxygen therapy for acute coronary syndrome
Hyperbaric oxygen therapy for Bell's palsy
Hyperbaric oxygen therapy for blunt chest injury
Hyperbaric oxygen therapy for calciphylaxis
Hyperbaric oxygen therapy for cancers and tumour sensitisation to radiotherapy
Hyperbaric oxygen therapy for cardio-pulmonary bypass
Hyperbaric oxygen therapy for chronic hepatitis
Hyperbaric oxygen therapy for Crohn's disease
Hyperbaric oxygen therapy for crush injuries
Hyperbaric oxygen therapy for malignant otitis externa
Hyperbaric oxygen therapy for multiple sclerosis
Hyperbaric oxygen therapy for osteoarthritis
Hyperbaric oxygen therapy for osteonecrosis of the mandible
Hyperbaric oxygen therapy for osteoradionecrosis
Hyperbaric oxygen therapy for other chronic wounds
Hyperbaric oxygen therapy for pain syndromes
Hyperbaric oxygen therapy for peridontitis
Hyperbaric oxygen therapy for pressure ulcers
Hyperbaric oxygen therapy for severe anaemia
Hyperbaric oxygen therapy for skin grafts and flaps
Hyperbaric oxygen therapy for soft-tissue radionecrosis
Hyperbaric oxygen therapy for surgery
Hyperbaric oxygen therapy for the treatment of livedoid vasculopathy
Hyperbaric oxygen therapy for traumatic brain injury
Hyperbaric oxygen therapy for treatment of necrotising soft-tissue infections
Hyperbaric oxygen therapy for venous ulcers
Hyperbaric oxygen therapy for wound healing
Hyperbarix oxygen therapy for soft-tissue radionecrosis
Hyperfractionated or accelerated radiotherapy for head and neck cancer
Hypnosis for people with asthma
Hypnotherapy and biofeedback therapy for atopic eczema
Hypnotherapy for Ménière's disease
Hypnotherapy for nocturnal enuresis
Hypothermia for traumatic head injury
Hypoventilation to decrease blood loss and blood transfusion requirements for liver resection
I recently became very depressed when my asthma inhaler was changed to Symbicort and felt much better when I gave myself a break from this inhaler. Is there any evidence that different inhalers have different effects on mood?
I take ventolin 2 puffs QDS & becotide 200mgs 2 puffs QDS. I constantly have coughing fits sometimes leading to vomiting or nose bleeds and stress incontinence. Are these recognised side effects of these treatments?
Ibuprofen and paracetamol in combination and separately for fever in pre-school children presenting to primary care
If a person benefiting from taking lithium for mood disorders stays on it, are adverse renal effects dose-related?
If doctors cannot diagnose asthma in children under 2, what is the most appropriate treatment?
If I can have my own choice of insulin, and how it is delivered, will my diabetes be better controlled?
If my child, who has asthma, is poorly but on medication, should I send him to school?
If toe nails are being cut round instead of straight, will this produce more ingrown nails?
Ileostomy or colostomy for temporary decompression of colorectal anastomosis
Image-guided percutaneous procedure plus metronidazole versus metronidazole alone for uncomplicated amoebic liver abscess
Immediate loading with single implant crowns
Immediate restoration/loading of immediately placed single implants: is it an effective bimodal approach?
Immediate versus delayed reconstruction following surgery for breast cancer
Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy
Immunonutrition in patients undergoing surgery for head and neck cancer
Immunosuppression in primary focal segmental glomerular sclerosis (FSGS) in adults
Immunosuppression in renal transplantation
Immunotherapy for diabetic amyotrophy
Immunotherapy vs conventional asthma pharmacotherapy and allergen immunotherapy
Impact of preconception counselling on quality of life and satisfaction of care in women with epilepsy
Importance of correct point location in acupuncture for migraine prophylaxis
In a critically ill patient is dopexamine effective at preventing renal failure?
In adults greater than 18 years of age with suspected transient ischaemic attack is the administration of aspirin by paramedics in prehospital care safe in the absence of a brain scan?
In an asthma emergency, what are the advantages and disadvantages of a nebuliser compared with filling up a spacer with multiple Ventolin squirts?
In cases of metastatic squamous cell carcinoma (SCC) in cervical lymph nodes with occult primary, in which circumstances is prophylactic wide field radiotherapy to potential primary sites beneficial in terms of loco-regional control and overall survival.
In cases of metastatic squamous cell carcinoma (SCC) in cervical lymph nodes with occult primary, is there any benefit in carrying out a PET/CT scan to locate the primary tumour?
In female patients complaining of loss of libido is there any evidence that hormone therapy (oestrogen or progestogen or androgen) is beneficial?
In patients identified on primary examination as exhibiting possible COAG, OHT or glaucoma suspect status, what is the comparative effectiveness of diagnosis by different healthcare professions?
In patients with asthma on inhaled steroids are symptoms better controlled or side effects improved when taking steroid using a Metered Dose Inhaler (MDI) and spacer or breath activated device?
In patients with asthma on oral steroids, which drugs/intervention are needed/effective in preventing or treating hypertension?
In patients with asthma on oral steroids, which drugs/intervention are needed/effective in preventing or treating loss of growth in children?
In people with chronic schizophrenia who have to stop clozapine, what is the most appropriate choice of antipsychotic in terms of symptom control and quality of life?
In the patient with severe asthma which deteriorates in pregnancy what is the best way to manage and monitor the condition?
In which circumstances is post operative radiotherapy to lymph node areas beneficial for Head and Neck cancer in terms of improving local control and overall survival?
Increased sunscreen use to reduce incidences of skin cancer
Individual and group based parenting programmes for improving psychosocial outcomes for teenage parents and their children
Individual Cognitive Behavioural Therapy for children with depression
Individual interventions by breast cancer nurses' and the effact on quality of life outcomes for women with breast cancer
Induction of labour for suspected fetal macrosomia
Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment
Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment
Infliximab for induction of remission of ulcerative colitis
Information interventions for orienting patients and their carers to cancer care facilities
Informative value of clinical research on multislice computed tomography in the diagnosis of coronary artery disease
Infrared laser treatment for acne
Inhaled antibiotics for long-term therapy in cystic fibrosis
Inhaled beta2-agonist and anticholinergic agents for emergency management of asthma in adults
Inhaled corticosteroid prophylaxis for exercise induced bronchoconstriction
Inhaled corticosteroids versus long-acting beta2-agonists for chronic obstructive pulmonary disease
Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma
Inhaled nitric oxide for respiratory failure in preterm infants
Inhaled or nebulised corticosteroids for hospitalised children with acute asthma
Initial antithyroid drugs followed by thyroxine or no treatment for primary hyperthyroidism
Injectable vaccines for preventing pneumococcal infection in patients with chronic obstructive pulmonary disease
Injection of allergen-antibody complexes of house dust mites for atopic eczema
Injection therapy for subacute and acute low back pain
Inpatient admission versus day hospital for schizophrenia
Insoles for low back pain
Inspiratory muscle stength training vs endurance training in patients with COPD to improve maximal inspiratory pressure and functional exercise capacity
Insulin delivery methods, other than injection.
Insulin detemir versus insulin glargine for type 2 diabetes mellitus
Insulin for glycaemic control in acute ischaemic stroke
Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome
Intense pulsed light therapy for acne
Intensive Case Management for severe mental illness
Interactive computer-based interventions for sexual health promotion
Interferon Alpha Adjuvant Therapy in Patients with High-Risk Melanoma
Interferon alpha for chronic hepatitis D
Interferon alpha-2b and ribavirin maintenance therapy for halting hepatitis C disease progression in liver-transplanted patients
Interferon beta for primary progressive multiple sclerosis
Intermittent catheterisation and indwelling catheters as first choice treatment for urinary incontinence
Intermittent drug techniques for schizophrenia
Intermittent drug techniques for schizophrenia
Intermittent iron supplementation for improving nutrition and development in children under 12 years of age
Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating women
Intermittent pneumatic compression for treating venous leg ulcers
Intermittent versus continuous androgen suppression for prostatic cancer
Internal fixation implants for intracapsular hip fractures in adults
Internal fixation versus arthroplasty for intracapsular proximal femoral fractures in adults
Internet-based interventions for smoking cessation
Intervention for developmental apraxia of speech
Interventions before pregnancy to improve pregnancy outcomes for women with epilepsy and their offspring
Interventions designed to prevent healthcare bed-related injuries in patients
Interventions for acute auricular haematoma
Interventions for acute internal hordeolum
Interventions for apathy after traumatic brain injury
Interventions for auditory processing disorder
Interventions for both male and female sexual dysfunction in chronic kidney disease
Interventions for cachexia-anorexia syndrome in people with lung cancer
Interventions for cough in cancer
Interventions for disorders of eye movement in patients with stroke
Interventions for ear discharge associated with grommets (ventilation tubes)
Interventions for erythrodermic psoriasis
Interventions for fatigue and weight loss in adults with advanced progressive illness
Interventions for guttate psoriasis
Interventions for helping people recognise early signs of recurrence in depression
Interventions for improving adherence to ocular hypotensive therapy
Interventions for improving asthma care in ethnic minorities
Interventions for improving coverage of child immunization in low- and middle-income countries
Interventions for improving mobility after hip fracture surgery in adults
Interventions for improving palliative care for older people living in nursing care homes
Interventions for infantile esotropia
Interventions for infantile haemangiomas (strawberry birthmarks) of the skin
Interventions for insomnia in conjunction with antipsychotic drug use
Interventions for intertriginous or flexural psoriasis
Interventions for nausea and vomiting in early pregnancy
Interventions for neovascular age-related macular degeneration
Interventions for normal tension glaucoma
Interventions for obsessive compulsive symptoms in people with schizophrenia
Interventions for Paget’s disease of the vulva
Interventions for pregnant women with hyperglycaemia not meeting gestational diabetes and type 2 diabetes diagnostic criteria
Interventions for preventing and reducing the use of physical restraints in long-term geriatric care
Interventions for preventing and treating hyperthyroidism in pregnancy
Interventions for preventing and treating squamous cell carcinoma of the conjunctiva in HIV-infected individuals
Interventions for preventing delirium in hospitalised patients
Interventions for preventing falls in older people living in the community
Interventions for preventing neuropathy caused by cisplatin and related compounds
Interventions for preventing non-melanoma skin cancers in high risks groups?
Interventions for preventing oral mucositis for patients with cancer receiving treatment
Interventions for preventing relapse and recurrence after the first episode of a depressive disorder in young people
Interventions for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Interventions for psoriasis in children
Interventions for psoriasis in obese people
Interventions for psoriasis in people with hepatitis C
Interventions for psoriasis in people with HIV infection
Interventions for psychosis in adolescents
Interventions for psychotic symptoms concomitant with epilepsy
Interventions for recurrent idiopathic epistaxis (nosebleeds) in children
Interventions for reducing itch in atopic eczema
Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants
Interventions for rosacea
Interventions for segmental vitiligo
Interventions for severe scalp psoriasis
Interventions for sexual dysfunction following treatments for cancer – excluding PDE5 inhibitors
Interventions for smokeless tobacco use cessation
Interventions for smoking cessation in Indigenous populations
Interventions for stimulus deprivation amblyopia
Interventions for strabismic amblyopia
Interventions for the management of dry mouth: topical therapies
Interventions for the management of oral submucous fibrosis
Interventions for the treatment of keratocystic odontogenic tumours (KCOT, odontogenic keratocysts (OKC))
Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy
Interventions for treating AIDS-associated Hodgkin acute lymphoma in treatment-naive adults
Interventions for treating anxiety after stroke
Interventions for treating chronic ankle instability
Interventions for treating oral candidiasis for patients with cancer receiving treatment
Interventions for treating oral leukoplakia
Interventions for treating oral mucositis for patients with cancer receiving treatment
Interventions for treating osteoarthritis of the big toe joint
Interventions for treating peripartum cardiomyopathy to improve outcomes for women and babies
Interventions for treating sexual dysfunction in patients with chronic kidney disease
Interventions for treatment of chronic hepatitis B in lamivudine-resistant patients
Interventions for unilateral refractive amblyopia
Interventions for visual field defects in patients with stroke
Interventions for vitiligo in children
Interventions other than anticoagulants and systemic antibiotics for prevention of central venous catheter-related infections in children with cancer
Interventions to correct chronic metabolic acidosis in patients with chronic kidney disease
Interventions to enhance return-to-work for cancer patients
Interventions to improve adherence to antiretroviral therapy in children with HIV infection
Interventions to improve compliance with treatment in schizophrenia
Interventions to improve occupational health in depressed people
Interventions to increase influenza vaccination rates of those 60 years and older in the community
Interventions to manage dual practice among health workers
Interventions to prevent sleep disruption in infants with atopic eczema
Interventions to reduce or relieve the pain and discomfort of screening mammography
Interventions to reduce risky sexual behaviour for preventing HIV infection in workers in occupational settings
Interventions to reduce Staphylococcus aureus in the management of atopic eczema
Interventions to reduce weight gain in schizophrenia
Interventions to slow progression of myopia in children
Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock
Intra-articular hyaluronate for rheumatoid arthritis
Intra-articular lignocaine versus intravenous analgesia with or without sedation for manual reduction of acute anterior shoulder dislocation in adults
Intracutaneous or subcutaneous sterile water injection compared with blinded controls for pain management in labour
Intramedullary nailing for tibial shaft fractures in adults
Intramedullary nails for extracapsular hip fractures in adults
Intramural urethral bulking procedures for stress urinary incontinence in women
Intranasal ipratropium bromide for the common cold
Intranasal ipratropium bromide with placebo for seasonal allergic rhinitis
Intranasal steroids for acute sinusitis
Intraoperative 5-Fluorouracil for glaucoma surgery
Intra-operative Mitomycin C for glaucoma surgery
Intraopetarive Radiotherapy for Solid Tumours
Intratracheal Clara cell secretory protein (CCSP) administration in preterm infants with or at risk of respiratory distress syndrome
Intratympanic gentamicin for Meniere's disease or syndrome
Intratympanic gentamicin in Ménière's disease
Intratympanic steroids for Ménière's disease and sudden sensorineural hearing loss
Intratympanic steroids for Ménière's disease or syndrome
Intra-vascular spread of Prostate Cancer by retorgrade saline 'transfusion' through the cut surface of the prostate during transurethral resection of the prostate (TURP)
Intra-venous fluids for the prevention of severe ovarian hyperstimulation syndrome
Intravenous immunoglobulin as a corticosteroid sparing agent for chronic asthma
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy
Intravenous immunoglobulin for suspected or subsequently proven infection in neonates
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
Intravenous inotropic drugs in acute heart failure
Intravenous magnesium sulphate for acute severe asthma
Intravenous nitrates or intravenous furosemide for acute heart failure
Intravenous polyclonal human immunoglobins for relapse-remitting multiple sclerosis
Intravesical Bacillus Calmette-Gu?rin versus epirubicin for Ta and T1 bladder cancer
Intravesical Bacillus Calmette-Guerin versus epirubicin for Ta and T1 bladder cancer
Intravesical gemcitabine for non-muscle invasive bladder cancer
Intravitreal bevacizumab (Avastin) vs. ranibizumab (Lucentis) for the treatment of age-related macular degeneration
Intravitreal corticosteroids to improve visual acuity in branch retinal vein occlusion
Intravitreal corticosteroids to improve visual acuity in central retinal vein occlusion
Intravitreal injection of Triamcinolone for diabetic retinopathy
Intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors for diabetic retinopathy
Intravitreal steroids versus observation for macular edema secondary to central retinal vein occlusion
In-vitro screening to test whether ataluren (PTC124) can correct functional consequences of premature termination mutations of the Flavin containing monooxygenase 3 (FMO3) gene?
Iodine solution for the prevention of chemotherapy-induced oral mucositis
Iodised salt for preventing iodine deficiency disorders
Iridectomy or iridotomy for preventing angle-closure glaucoma
Is 6 months of trastuzumab treatment sufficient when compared with 12 months?
Is acupuncture effective for peripheral joint osteoarthritis?
Is an artificial pancreas for type 1 diabetes (closed loop system) effective?
Is antidepressant medication safe for the foetus and mother if taken during pregnancy?
Is any specific surgical intervention effective in Ménière's disease and what procedure is best?
Is ascorbic acid effective in managing anaemia in haemodialysis patients?
Is Atrovent for asthma less likely to cause giddiness, nausea, shaking, headache and palpitations than salbutamol or Ventolin?
Is bibliotherapy effective for relieving psychotic symptoms?
Is bortezomib an effective therapy for Post Transplant Lymphoproliferative Disorders?
Is carbogen gas effective in the treatment of sudden sensorineural hearing loss?
Is Clozapine particularly effective in reducing hostility, violence and reducing suicide rates in schizophrenia?
Is Cognitive Behavioural Therapy equally effective for all psychiatric conditions?
Is Cognitive Behavioural Therapy equally useful in patients with and without active medication?
Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?
Is continuous medication beneficial for my asthma if I don't have symptoms?
Is counselling adequate for schizophrenia?
Is DAFNE an effective patient education system for people with diabetes?
Is daily use of a Becotide inhaler necessary for asthma in children?
Is desmopressin effective in reducing nocturia and enuresis in elderly men?
Is desmopressin used for urinary incontinence safe and effective in patients over 60?
Is dietary and lifestyle advice effective in the treatment of overactive bladder?
Is Disease Management more effective than good quality usual care for heart failure?
Is drug therapy more effective than psychotherapy in treating emotional distress?
Is ECT advised to treat mood disorders in people with schizophrenia?
Is ECT more effective and/or safer for the foetus, in severe depressive states, during the perinatal period than antidepressant medication?
Is ECT over the long term effective in treating schizophrenia?
Is finasteride effective in reducing nocturia in benign prostatic hyperplasia?
Is fish oil effective at reducing nephrotoxicity in kidney transplant recipients?
Is growth hormone treatment effective for children with chronic kidney disease?
Is hand and feet numbness associated with use of certain antiepileptic drugs?
Is homeopathic medication useful for asthma?
Is injected medication preferable to preventer inhalers for children with asthma?
Is insulin pump therapy effective? (immediate v deferred pump, and comparing outcomes with multiple injections)
Is it better to inhale steroids for my asthma rather than take them as tablets?
Is it helpful for patients with balance disorders to adopt a specific diet?
Is it helpful for patients with balance disorders to reduce/avoid salt intake?
Is it helpful in preventing the severity, frequency and progression of attacks of Ménière's disease to adopt a specific diet, or restrict salt, caffeine or fluid intake?
Is it necessary to take the preventive inhaler everyday?
Is it possible to constantly and accurately monitor blood sugar levels, in people with type 1 diabetes, with a discrete device (microchip, implant for example) ?
Is it possible to step-down to lower dose, combination inhalers, such as Seretide or Symbicort for people with asthma?
Is it really necessary to take preventative medication if I only have mild asthma?
Is it safe to breastfeed on certain anti-epileptic drugs?
Is it safe to have a full body massage following Myocardial Infarction?
Is it safe to use steroids in children under two with asthma? What are the side effects and will I damage my child in the long term?
Is it true that atmospheric pressure/weather influences balance disorders, and how might this best be managed?
Is laser or diathermy ablation of endometriosis more likely to result in pregnancy in patients with subfertility?
Is laser therapy or other light therapies effective for a 40-year-old woman with rosacea on the face, who also had prior metranidazole cream and tetracycline with no success?
Is Ménière's disease triggered or exacerbated by any specific medication (and my implication is avoidance of those drugs helpful)?
Is metformin combined with insulin treatment in children and young people with type 1 diabetes better than treatment with insulin alone?
Is monochloroacetic acid more effective for the treatment of warts than liquid nitrogen?
Is neurostimulation effective in managing a neurogenic bladder?
Is olanzapine dangerous in patients with hyperglycaemia?
Is once daily insulin effective in treating children and young people with type 1 diabetes?
Is once daily insulin injection regime in children and young people with type 1 diabetes, especially in pre-school children, as effective as more complicated regimens?
Is one type of splint superior to another for osteoarthritis of the carpometacarpal joint?
Is physical therapy (electro-acupuncture, TENS and low level laser therapy) effective for osteoarthritic knee pain?
Is physiotherapy helpful for controlling asthma?
Is Pranayam Yoga helpful in asthma?
Is procyclidine effective in treating tardive dyskinesia if taken in conjunction with antipsychotics?
Is protein Z influenced by the acute phase response?
Is pseudocatalase cream combined with brief exposure to UVB light as recommended, effective in treating vitiligo?
Is PUVA therapy more effective if used to treat vitiligo when it first appears, rather than waiting until the disease has spread?
Is recombinant human growth hormone (rhGH) therapy effective to improve cardiovascular effects in patients with congestive heart failure caused by left ventricular systolic dysfunction?
Is regulation of body temperature affected by use of antiepileptic drugs?
Is risperidone less likely than other antipsychotic drugs to cause tardive dyskinesia?
Is rituximab therapy associated with a higher rate of relapse in kidney transplant patients with post-transplant lymphoproliferative disorder?
Is selective or routine stenting in renal transplantation effective?
Is Symbicort less likely to cause mucus formation than Advair in asthma?
Is systematic banking of colostrum antenatally of any benefit in pregnancies complicated by diabetes?
Is tension free vaginal tape surgery in women with mixed incontinence associated with better outcomes than maximal conservative treatments in terms of continence and quality of life?
Is the Buteyko breathing method useful for helping me control my asthma symptoms?
Is the effect of antipsychotic medication altered by illicit drug use or excessive alcohol consumption?
Is the treatment of ovarian endometriomas by coagulation, vapourisation, excision or cystectomy associated with a significant increase in cyst recurrence?
Is the use of antispychotic drugs in eldely patients more dangerous?
Is the use of Direct Renin Inhibitors complementary to or better than ACE/ARB in diabetic and also in non-diabetic nephropathy?
Is the use of insulin analogues associated with an increase in cancer rates?
Is there a bacteria responsible for producing trimethylamine (TMA) in the gut?
Is there a causative association between oral isotretinoin and depression and suicidal behaviour in acne patients?
Is there a difference in efficacy and acceptability of three currently available topical treatments in terms of clearance of pre-cancerous actinic keratoses (AK) and persistence of clearance of AK over 1 year?
Is there a difference in quality of life between those who use basal bolus or twice daily mixed insulin regimens?
Is there a genetic marker for prostate cancer that would be both more sensitive and more specific than PSA serum level?
Is there a more accurate test than the serum B12 test for monitoring pernicious anaemia, such as monitoring B12 analogues (that which the body cannot use)?
Is there a role for polypharmacy with B12 for treating pernicious anaemia?
Is there a role for statins in atrial fibrillation?
Is there a vaccine that can prevent prostate cancer?
Is there an effective drug to treat akathisia as a side effect of long term antipsychotic medication?
Is there any benefit for people with Type 1 diabetes from the addition of metformin to insulin treatment?
Is there any difference in the effects of PowerBreath and Buteyko breathing exercises in controlling asthma?
Is there any evidence for combination inhalers, e.g. Symbicort for people with asthma?
Is there any evidence for the use of metronidazole gel in the treatment of fungating breast cancer? Also can it be used in conjunction with actisorb silver to reduce bacterial load?
Is there any evidence of a better cure rate for treating proven fungal toe nail infections with both oral and topical preparations?
Is there any evidence that prolonged use of inhaled steroids in asthma (e.g. fluticasone) causes an increased susceptibility to upper or lower respiratory tract infections?
Is there any evidence that supports consensus language/approaches within the people/health professionals educating for the care of people with asthma?
Is there any evidence to support giving the influenza vaccine to children with asthma?
Is there any evidence to support the use of silver dressing products?
Is there any information about the use of oestrogen (patches or oral forms) for the treatment of flushing in elderly men?
Is there any information on the role of postal or telephone communication in the management of asthma?
Is there any specific treatment to prevent drop attacks in patients with Ménière's disease?
Is there any value in treatments such as Deep Brain Stimulation (DBS) or psychosurgery for people with severe mental illness?
Is there evidence that any type of insulin is superior to purified pork insulin?
Is there evidence that Seretide causes chest pain, foot muscle pains, insomnia, hoarseness and stomach bloating/pains?
Is thromboprophylaxis in patients in the ICU setting effective?
Is treatment with Light Emitting Diodes (LED), and other new technologies for phototherapy be beneficial for adults with psoriasis and psoriatic arthritis?
Is urethral dilation effective in treating urge incontinence in multiple sclerosis?
Is urinary diversion surgery more effective than indwelling catheterisation (urethral or suprapubic) for the management of a neurogenic bladder in patients with spina bifida?
Is urinary diversion surgery more effective than indwelling catheterisation (urethral or suprapubic) for the management of a neurogenic bladder in patients with spina bifida?
Is urodynamic testing prior to treatment decisions for mixed urinary incontinence associated with better continence rates and quality of life than treatment indicated by history, examination, free uroflowmetry, stress test and bladder diary?
Is UVB light therapy more effective in treating vitiligo when it first appears, rather than waiting until the disease has spread?
Is vitamin d3 an effective therapy for irritable bowel syndrome?
Is Xolair (omalizumab) an effective asthma medication for people with low IGE?
Ischaemic pre-conditioning for elective liver resections performed under vascular occlusion
Kangaroo mother care to reduce morbidity and mortality in low birthweight infants
Lactobacilli for maintenance of remission for Crohn's disease in children
Lamivudine or adefovir dipivoxil alone or combined with immunoglobulin for preventing hepatitis B recurrence after liver transplantation
Lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B
Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma
Lamotrigine adjunctive therapy for refractory generalized tonic-clonic seizures
Lamotrigine for acute and chronic pain
Language skills development for those with English as a second language against using interpreters for those with schizophrenia
Lanzhou Lamb rotavirus vaccine versus placebo for the prevention of rotavirus diarrhoea
Laparoscopic surgery for pelvic pain associated with endometriosis
Laparoscopic surgery for ulcerative colitis
Laparoscopic techniques for treating pelvic pain associated with endometriosis
Laparoscopic versus open distal gastectomy for gastric cancer
Laparoscopic versus open nephrectomy for live kidney donors
Laparoscopic versus open surgery for colon cancer in elderly patients with comorbidities
Laparoscopic versus open surgery for colon cancer in obese patients
Laparoscopic versus open surgery for colon cancer in patients with tumours in the left flexure
Laparoscopic versus open surgery for colon cancer in patients with tumours in the transverse colon
Laparoscopic versus open surgery for rectal cancer
Laparoscopic versus open surgery in small bowel obstruction
Laparoscopic versus open surgical techniques for ventral or incisional hernia repair
Larval (maggots) therapy effective in the treatment of infected diabetic foot ulcers
Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome
Laser peripheral iridoplasty for angle-closure
Laser resurfacing for treating facial acne scars
Laser trabeculoplasty for open angle glaucoma
Laser trabeculoplasty plus topical medical treatment for open angle glaucoma
Laser treatments versus conventional, drug therapies for acne
Lasers or light sources for treating port-wine stains
Leflunomide for psoriasis
Length of duration of improvements associated with acupuncture treatment for migraine
Length of treatment time for patients with pure sleep-related epilepsy
Lens extraction for chronic angle-closure glaucoma
Leucotriene receptor antagonists in addition to usual care for acute asthma in adults and children
Leucotriene receptor antagonists in addition to usual care for acute asthma in adults and children
Leukotriene receptor antagonists in primary care at steps two and three of the national asthma guidelines
Leukotriene receptor antagonists in the treatment of nasal polyps
Levodopa for the treatment of restless legs syndrome
Levomepromazine for schizophrenia
Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery
Levosimendin in acute heart failure
Lifestyle changes in women with polycystic ovary syndrome
Lifestyle factors in the prevalence and severity of urinary incontinence and overactive bladder.
Lifestyle intervention on the treatment of urinary incontinence
Lifestyle interventions for the treatment of urinary incontinence in adults
Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates
Limited (regional) fasciectomy for Dupuytren’s contractures of the hand
Liquid and fluid agents for preventing adhesions after surgery for subfertility
Lithium augmentation for depression
Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity
Local corticosteroid injections for arthritic pain
Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia
Local opinion leaders: effects on professional practice and health care outcomes
Long term adverse effects of antipsychotic medication
Long term adverse effects of antipsychotic medication
Long term adverse effects of clozapine
Long term adverse effects of clozapine (Clozaril)
Long term benefit of adult aural rehabilitation programs
Long term benefit of the Epley manoeuvre for benign paroxysmal positional vertigo
Long term consequences of short term hormonal therapy for endometriosis-associated pain
Long term effectiveness of middle ear implants for hearing impairment
Long term effects of antipsychotic drugs on kidneys.
Long term effects of bilateral cochlear implants for profound deafness
Long term effects of cognitive behavioural therapy for tinnitus
Long term effects of glucocorticoid therapy for rheumatoid arthritis
Long term effects of grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children
Long term effects of grommets (ventilation tubes) for recurrent acute otitis media in children
Long term outcomes of cochlear implantation in the first year of life
Long term outcomes of laparoscopic surgery for cancer of the upper rectum
Long term results of antiviral treatment for chronic hepatitis B
Long term results of medical versus surgical management for gastro-oesophageal reflux disease in adults
Long term safety of Omalizumab in the treatment of allergic rhinitis
Long term side effects of amisulpride for schizophrenia
Long term side effects of antipsychotics
Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma
Longchain polyunsaturated fatty acid supplementation in preterm infants
Long-term antibiotic treatment for Crohn's disease
Long-term antibiotics for preventing recurrent urinary tract infection in children
Long-term effect of staff education and on-the-job training on patient urinary incontinence outcomes
Long-term effects of anti-vascular endothelial growth factor therapies for exudative age-related macular degeneration
Long-term effects of anti-vascular endothelial growth factor therapies for neovascular age-related macular degeneration
Long-term effects of weight-reducing diets in hypertensive patients
Long-term efficacy and safety of ciclosporin (cyclosporin) for atopic eczema
Long-term efficacy and safety of oral azathioprine for atopic eczema
Long-term efficacy of autologous pancreatic islet cell transplantation (after pancreatectomy) for improved glycaemic control in patients with diabetes
Long-term efficacy of UVA1 phototherapy for acute atopic eczema
Long-term outcomes of hormonal treatment for infantile spasms
Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with mild or severe endometriosis
Long-term safety and adverse effects of ultraviolet light therapy for atopic eczema in children
Long-term safety and adverse events in topical treatments for chronic plaque psoriasis
Long-term safety of biological therapies for psoriasis, including risk of malignancies
Long-term safety of pimecrolimus and tacrolimus for atopic eczema
Long-term safety of topical corticosteroids for atopic eczema, specifically in relation to bones and eyes
Long-term safety of topical steroids for atopic eczema
Long-term safety of topical steroids for repigmentation in vitiligo
Long-term value of anticholinergic drug treatment for urinary incontinence
Low central venous pressure to decrease blood loss and blood transfusion requirements for liver resection
Low dose versus standard dose isotretinoin for acne
Low glycaemic index, or low glycaemic load, diets for diabetes mellitus: long-term effects, quality of life, mortality, morbidity and cost-effectiveness.
Low molecular weight heparin (LMWH) compared with compression therapy for deep vein thrombosis (DVT) prophylaxis.
Low molecular weight heparin versus catheter-directed thrombolysis in proximal lower limb deep vein thrombosis
Low molecular weight heparin versus unfractionated heparin for perioperative thromboprophylaxis in patients with cancer
Low pressure versus standard pressure pneumoperitoneum in elective laparoscopic cholecystectomy
Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy in patients with acute cholecystitis
Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy in patients with cardiopulmonary disorders
Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants
Low-dose Computerised tomography in early diagnosis of patients at high risk of developing lung cancer
Low-dose rate brachytherapy for men with localized prostate cancer
Lower drug dosages for urinary incontinence in older people than used in younger populations
Low-fat diets for acquired hypercholesterolaemia
Lubiprostone for irritable bowel syndrome in male patients
Lung volume reduction surgery for diffuse emphysema
Luteal phase support for assisted reproduction cycles
Lutein or zeaxanthin for age-related macular degeneration to slow or prevent distance visual acuity loss or progression
Luteinizing hormone-releasing hormone analogue as a single agent or a combined androgen blockade agent for prostate cancer
Lycopene for the prevention of prostate cancer
Macrolide antibiotics for cystic fibrosis
Macrolides for diffuse panbronchiolitis
Magnesium for primary and secondary dysmenorrhoea
Magnesium sulphate for severe acute asthma
Maintenance treatment with antipsychotic drugs for schizophrenia
Management of daytime enuresis in children
Management of incontinence after stroke
Management of lymphoedema following surgery for breast cancer
Management of sexual dysfunction due to antipsychotic drug therapy
Management of the clinically negative neck (N0) of supraglottic laryngeal carcinoma
Management of the hepatic lymph nodes during resection of liver metastases from colorectal cancer
Management of trismus induced by cancer therapies in head and neck cancer patients
Manipulative interventions (pronation versus supination) for pulled elbow in young children
Manual chest physiotherapy for infective exacerbations of chronic obstructive pulmonary disease
Manual therapy for adolescent idiopathic scoliosis
Manual therapy for non-specific thoracic pain in adults
Marital therapy for depression
Massage for low back pain
Massage therapy for atopic eczema
Material incentives and enablers in the management of tuberculosis
Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing atopic eczema in the child
Maternal hydration for increasing amniotic fluid volume in oligohydramnios and normal amniotic fluid volume
Mechanical bowel preparation for elective colorectal surgery
Mechanical dilatation of the cervix at non-labour caesarean section for reducing postoperative morbidity
Mechanical traction for chronic neck pain
Mechanical ventilation versus no mechanical ventilation for people with severe acute asthma
Mechanical versus manual chest compressions for cardiac arrest
Medical interventions for high grade vulval intraepithelial neoplasia
Medical interventions for primary open angle glaucoma and ocular hypertension
Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer
Medical interventions for treating chronic pelvic pain in women
Medical interventions for treating chronic primary angle-closure glaucoma
Medical treatment for botulism
Medical treatments for painful bladder syndrome (interstitial cystitis)
Medical versus surgical interventions for open angle glaucoma
Medical versus surgical termination of pregnancies less than 14 weeks' gestation
Medically assisted hydration for adult palliative care patients
Meditation (including relaxation techniques) for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Meditation and yoga for depression
Meditation and yoga for schizophrenia
Megavitamins for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Melanocyte transplantation for repigmentation in vitiligo
Melatonin for non-respiratory sleep disorders in visually impaired children
Melatonin for the treatment of dementia
Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke
Mentoring adolescents to prevent drug and alcohol use
Mesalamine for lymphocytic colitis or collagenous colitis
Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents
Methadone for cancer pain
Methods of decreasing infection to improve outcomes after liver resections
Methods to decrease blood loss and transfusion requirements for liver transplantation
Methotrexate combination therapy with non-biologic disease modifying antirheumatic drugs for treating rheumatoid arthritis in adults
Methotrexate for maintenance of remission in Crohn's disease
Methotrexate for maintenance of remission in ulcerative colitis
Methylprednisolone for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Metoclopramide for migration of naso-enteral tube
Micropigmentation for vitiligo
Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Milnacipran versus other antidepressive agents for depression
Mind-body interventions during pregnancy for preventing or treating women's anxiety
Minimal effective dose of octreotide to prevent post-ERCP pancreatitis
Minimally invasive parathyroid surgery for hyperparathryoidism
Minimally invasive sling operations for stress urinary incontinence in women
Miniport versus standard ports for elective laparoscopic cholecystectomy
Miniport versus standard ports for emergency laparoscopic cholecystectomy
Minipunch skin grafts for repigmentation in vitiligo
Mirtazapine for depression
Mirtazapine versus other antidepressive agents for depression
Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery
MLN-02 for induction of remission in ulcerative colitis
Models for individual oral health promotion and their effectiveness
Modern combined oral contraceptives for pain associated with endometriosis
Modifications of the Epley (canalith repositioning) manoeuvre for posterior canal benign paroxysmal positional vertigo (BPPV)
Mometasone for asthma in adults and children
Monochromatic excimer light (MEL) for repigmentation in vitiligo
Monoclonal antibody treatment for recurrent head and neck cancer
Monoclonal CCR5 antibody for treatment of people with HIV infection
Monosodium glutamate avoidance for chronic asthma in adults and children
Monotherapy for seizure control in neonatal seizures
Monotherapy with benzoyl peroxide or topical retinoids versus combination topical therapy in the initial treatment of mild acne
Morphine for acute decompensated heart failure
Morphine in acute coronary syndromes
Mortality and adverse effects of peginterferon alpha-2a versus peginterferon alfa-2b in treatment of chronic hepatitis C
Mortality and quality of life with protective defunctioning stoma versus no stoma protection in low anterior resection for rectal carcinoma
Most effective probiotic treatment (species, strain, dose) for irritable bowel syndrome
Motivational interventions for drug and alcohol use in schizophrenia
Motivational interviewing for substance abuse
Moulding helmets for head shape abnormality (plagiocephaly) in babies
Multi-channel cystometry for urinary incontinence or overactive bladder.
Multi-component interventions for nocturia
Multidisciplinary rehabilitation for adults with multiple sclerosis
Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers
Muscle relaxants for pain management in rheumatoid arthritis
Music for stress and anxiety reduction in coronary heart disease
Music interventions for improving psychological and physical outcomes in cancer patients
Music interventions for mechanically ventilated patients
Music therapy for depression
Music therapy for people with dementia
My 18 month-old child has very unstable asthma. What is the best treatment?
My daughter is taking olanzapine for schizophrenia. Could I give her Nytol (diphenhydramine) and olanzapine?
My daughter who has been diagnosed with asthma only seems to become wheezy when she takes her steroid inhaler. Should this be happening?
My son finds it difficult to use a spacers and masks to take his inhaled medication for his asthma. How do I know he is getting the correct dose? Are there alternatives?
My son has schizophrenia. He was on Clozapine and transferred to aripiprazole. He's now becoming unwell. Is it better to switch straight back to clozapine, taper the doses or combine the two?
My two-year old child has been taking salbutamol for asthma and it does not seem to help. Is there a better treatment?
Myomectomy of fibroids for improving chances of becoming pregnant
Naftidrofuryl for dementia
Narrow band imaging versus conventional white light colonoscopy for the detection of colorectal polyps
Narrow band UVB monotherapy for repigmentation in vitiligo
Narrow excision margins versus wide excision margins on disease-specific survival of patients with primary cutaneous melanoma
Narrowband UVB compared to PUVA for psoriasis
Natalizumab (alone or in combination with other therapies) for multiple sclerosis
Natalizumab for relapsing remitting multiple sclerosis
Nebulisers versus hand-held inhalers to deliver beta2-agonist bronchodilator drugs in non-acute asthma
Nebulized epinephrine for croup in children
Nebulized hypertonic saline solution for acute bronchiolitis in infants
Neck dissection following chemo-radiotherapy in advanced head and neck squamous cell carcinoma
Nedocromil sodium for chronic asthma in children
Needling for encapsulated trabeculectomy filtering blebs
Neoadjuvant chemotherapy versus none for resectable gastric cancer
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
Neuromodulation with implanted electrodes for urinary storage and voiding dysfunction in adults
Neuromodulators for pain management in rheumatoid arthritis
Neuromuscular electrical stimulation for stress urinary incontinence
Neuroprotection for prevention and treatment of glaucoma in adults
Neuroprotective agents i.e. memantine for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Neuropsychological rehabilitation for multiple sclerosis
Neurosurgery for depressive disorders
Neurosurgical interventions for the treatment of classical trigeminal neuralgia
Newborn screening for homocystinuria
Newer anticoagulants such as fondaparinux and ximelagatran in cancer patients with central venous catheters
Nicotine receptor partial agonists for smoking cessation
Nitrates for achalasia
Nitric oxide donors for the treatment of preterm labour
Nitrous oxide for colonoscopy
Non steroidal anti-inflammatory drugs for the prevention of colorectal adenomas
Non-acoustic benefits of bone-anchored hearing aids
Non-antibiotic pharmaceutical treatment of acute otitis media
Non-antibiotic treatments for sore throat
Non-drug therapies for lower limb muscle cramps
Non-immunosuppressive treatment for IgA nephropathy
Non-invasive brain stimulation techniques for chronic pain
Non-invasive positive pressure ventilation
Non-invasive ventilation for ventilatory failure in asthma
Non-laser light treatments versus conventional, drug therapies for acne
Non-penetrating filtration surgery versus trabeculectomy for open angle glaucoma
Non-pharmacological interventions for caregivers of stroke survivors
Non-pharmacological interventions for epilepsy in people with intellectual disabilities
Non-pharmacological interventions for perceptual disorders following stroke and other adult-acquired, non-progressive brain injury
Non-pharmacological interventions for preventing venous insufficiency in a standing worker population
Non-pharmacological interventions that allow safe wandering for people with dementia
Non-pharmacological management of infant and young child procedural pain
Non-selective beta agonists versus beta2-agonists for acute asthma
Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies
Non-steroidal anti-inflammatory drugs for pain in women with endometriosis
Non-surgical interventions for convergence insufficiency
Notification and support for people exposed to the risk of Creutzfeldt-Jakob disease (CJD) (or other prion diseases) through medical treatment (iatrogenically)
Nurse education of parents of children with atopic eczema
Nurse-led versus doctor-led clinics in the management of childhood atopic eczema
Nursing interventions to assist elders in coping with hearing impairment
Nutritional supplementation for hip fracture aftercare in older people
Nutritional support for acute kidney injury?
Nutritional support for critically ill children
Nutritional support for head and neck cancer patients receiving radiotherapy
Nutritional support in children and young people with cancer undergoing chemotherapy
Occupational therapy for cognitive impairment in stroke patients
Octreotide for the treatment of chylothorax in neonates
Oculogyric crisis in antipsychotic treatment of schizophrenia
Oestrogen therapy compared to placebo as well as, and as a supplement to, both surgical or non-surgical management in post-menopausal women with urinary incontinence.
Oestrogens for treatment or prevention of pelvic organ prolapse in postmenopausal women
Oestrogens for urinary incontinence in women
Of alarms, desmopressin or tricyclic drugs, which is most effective as the first line treatment of nocturnal enuresis in children?
Older People's Exercise intervention in Residential and nursing Accommodation (OPERA)
Omega 3 and omega 6 fatty acids for prevention of atopic eczema
Omega 3 fatty acids for maintenance of remission in Crohn's disease
Omega 3 fatty acids to halt progression of age-related macular degeneration
Omega 3 fatty acids to prevent age-related macular degeneration
Omega-3 fatty acids for cystic fibrosis
Omega-3 fatty acids supplementation for autism spectrum disorders (ASD)
Once an antipsychotic medication is started for someone for a first episode of psychosis, how long do they need to keep taking them before we can start reducing the dose or consider stopping medication?
Once daily betamethasone for atopic eczema compared to once daily "new" topical corticosteroids (mometasone furoate, fluticasone propionate, methylprednisolone aceponate)
Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media
One site versus two site phacotrabeculectomy for primary open angle glaucoma
One-to-one psychological therapy versus group interventions for schizophrenia
Open fasciotomy for Dupuytren’s contractures of the hand
Open versus laparoscopic ileo pouch anal anastomosis for ulcerative colitis and familial adenomatous polyposis
Opioid therapy for treating rheumatoid arthritis pain
Opioids for low back pain
Opioids for osteoarthritis of the knee or hip
Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy
Optimal allergen dosage of sublingual immunotherapy for allergic rhinitis
Optimal analgesic(s) for pain after tonsillectomy in children
Optimal antiviral therapy of chronic hepatitis B
Optimal approach to pelvic floor muscle training for urinary incontinence in women
Optimal cut-off value for protein Z in the estimation of thrombotic risk
Optimal dilution of topical corticosteroids for atopic eczema
Optimal dosage of ACTH (or tetracosactide) for infantile spasms
Optimal dose of folate supplementation in treatment of psoriasis with methotrexate
Optimal dose of stereotactic radiosurgery for acoustic neuromas
Optimal dosing protocols for UVB therapy of chronic atopic eczema
Optimal dosing regime/re-treatment benefits of anti-vascular endothelial growth factor modalities in the treatment of age-related macular degeneration
Optimal duration of pegatheron plus ribavirin therapy for chronic hepatitis C in patients with HIV
Optimal Duration of pulmonary rehabilitation in COPD patients for quality of life and exercise capacity
Optimal duration of therapy in HBeAg-negative hepatitis B patients
Optimal follow up following recovery from an asthma attack
Optimal frequency and duration of acupuncture sessions for migraine prophylaxis
Optimal frequency of application of topical corticosteroids for atopic eczema
Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease
Optimal maintenance regimen after cessation of UVA1 phototherapy for acute atopic eczema
Optimal management of anticoagulated moderate-high risk patients with atrial fibrillation who present with an acute coronary syndrome and/or undergo percutaneous coronary intervention +/- stent implantation
Optimal primary surgical treatment for advanced epithelial ovarian cancer
Optimal ribivirin dose for chronic hepatitis C when taking in combination with pegylated interferon alpha-2a or alpha-2b
Optimal size and duration of placement of self-expanding plastic stents for benign oesophageal strictures
Optimal surgical management of vesicovaginal and/or urethrovaginal fistula
Optimal surgical procedure for obstruction from primary left colorectal carcinoma
Optimal surgical treatment for anorectal fistula
Optimal vehicle for application of topical corticosteroids for atopic eczema
Optimisation of thyroid hormone dose for treatment of myxedema coma
Optimization of thyroid hormone dose for treatment of myxedema coma
Optimum chemotherapy backbone for bevacizumab treatment of metastatic colorectal cancer
Optimum dexamethasone dosing for recovery following tonsillectomy
Optimum imfliximab introduction period for steroid withdrawal in inflammatory bowel disease
Optimum method of altered fractionated radiotherapy for head and neck cancer
Oral and systemic steroids at different doses for acute asthma in hospitalised children
Oral antioxidants plus phenylalanine for repigmentation in vitiligo
Oral cobamamide for repigmentation in vitiligo
Oral contraceptive pill as a treatment in women with primary dysmenorrhoea
Oral contraceptive pill compared to nonsteroidal anti-inflammatories for treating women with primary dysmenorrhoea
Oral dapsone for acne
Oral decongestants alone for seasonal allergic rhinitis in adolescents and adults
Oral gingko biloba extract for repigmentation in vitiligo
Oral health advice for people with serious mental illness
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants
Oral levamisole as an adjuvant to vaccination for hepatitis B virus seroprotection
Oral levamisole plus mometasone furoate cream for repigmentation in vitiligo
Oral minipulses of betamethasone for repigmentation in vitiligo
Oral minipulses of betamethasone plus narrow band UVB for repigmentation in vitiligo
Oral minipulses of betamethasone plus PUVA for repigmentation in vitiligo
Oral naltrexone maintenance treatment for opioid dependence
Oral phenylalanine followed by UVA for repigmentation in vitiligo
Oral pimecrolimus for psoriasis
Oral Polypodium leucotomos plus narrow band UVB for repigmentation in vitiligo
Oral Polypodium leucotomos plus PUVA for repigmentation in vitiligo
Oral psoralens with sunlight (oral PUVAsol) for repigmentation in vitiligo
Oral steroids for nasal polyps
Oral substitution treatment of injecting opioid users for prevention of HIV infection
Oral theophylline for stable asthma in adults
Oral vaccines for preventing cholera
Oral xanthines as maintenance treatment for asthma in children
Oropharyngeal dysphagia behavioral treatments -- impact of dysphagia treatment on individuals' postcancer treatments
Osteotomy for knee osteoarthritis
Osteotomy, compression and other modifications of surgical techniques for internal fixation of extracapsular hip fractures
Outcomes of assisted reproduction after excisional surgery with drainage and ablation of ovarian endometriomata
Ovarian function after drainage and ablation of ovarian endometriomata
Over-the-counter (OTC) treatments for acne, apart from benzoyl peroxide
Oxcarbazepine for acute affective episodes in bipolar disorder
Oxygen therapy for acute myocardial infarction
Oxygen therapy for cystic fibrosis
Oxygen therapy for heart failure
Oxygen versus air for nebulising beta-agonist bronchodilators in acute asthma
Oxytocin versus no treatment or delayed treatment for slow progress in the first stage of spontaneous labour
Pacifier use versus no pacifier use in breastfeeding term infants for increasing duration of breastfeeding
Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondylarthritis) and gastrointestinal or liver comorbidity
Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity
Pain management prior to, during and following treatment for head and neck cancer
Paliperidone for schizophrenia
Palliative care for heart failure
Palliative endobronchial brachytherapy for non-small cell lung cancer
Palliative surgery versus medical management for bowel obstruction in ovarian cancer
Pancreatic enzymes for chronic pancreatitis
Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma
Pantothenic acid (vitamin B5) for acne
Paracetamol for low back pain
Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy
Parathyroid hormone alone or in combination with antiresorptive therapy for bone mineral density
Parathyroid hormone for the treatment of osteoporosis
Parent training interventions for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 5 to 18 years
Parenteral anticoagulation for prolonging survival in patients with cancer who have no other indication for anticoagulation
Parenteral opioids for maternal pain relief in labour
Parenteral versus oral iron therapy for adults and children with chronic kidney disease
Paroxetine depression
Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia
Partially hydrolyzed whey protein formula for preventing atopic eczema in infants
Patellar tendon versus hamstring tendon autograft for anterior cruciate ligament rupture in adults
Patient adherence to treatment in heart failure
Patient education awareness of new technological developments
Patient education for chronic low back pain
Patient education in the management of coronary heart disease
Patient information on treatment options for urinary incontinence to improve access to appropriate care
Patients on antidiabetic medication testing false positive for recreational drugs
Pedicle screw constructs in adolescent idiopathic scoliosis
Peginterferon plus ribavirin versus no treatment for chronic hepatitis C in patients with HIV
Pegylated interferon alpha-2a plus ribavirin vs pegylated interferon alpha-2b plus ribavirin for chronic hepatitis C
Pegylated interferon and ribavirin in liver transplant candidates and recipients with HCV cirrhosis
Pelvic floor exercise to treat urinary incontinence in men after prostate surgery
Pelvic floor exercises for urge urinary incontinence.
Pelvic floor muscle function and bladder training for primary prevention of urinary incontinence in older adults
Pelvic floor muscle training as part of prenatal care to prevent incontinence
Pelvic floor muscle training compared with another active treatment for urinary incontinence in adults
Pelvic floor muscle training for men post-prostatectomy
Pelvic floor muscle training for women with stress urinary incontinence
Pelvic floor muscle training in combination with another therapy compared with the other therapy alone for urinary incontinence in women
Pelvic floor muscle training in combination with another therpay compared with the other therapy alone
Pemetrexed disodium in combination with cisplatin versus other cytotoxic agents or supportive care for the treatment of malignant pleural mesothelioma
Pentoxifylline compared to medical treatment or surgery in women with subfertility and endometriosis
Pentoxifylline for alcoholic hepatitis
Pentoxifylline for intermittent claudication
Pentoxyfilline as a treatment for proteinuria
Perazine for schizophrenia
Percutaneous acetic acid injection for early hepatocellular carcinoma
Percutaneous ethanol injection for early hepatocellular carcinoma
Percutaneous fasciotomy for Dupuytren’s contractures of the hand
Percutaneous needle aspiration, injection, and reaspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts
Percutaneous pinning for distal radial fractures in adults
Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis
Perflouro alkoxy plastic versus metal palliative biliary stents for obstructing pancreatic carcinoma
Performance measures and outcome in Chronic Heart Failure
Perianal injectable bulking agents as treatment for faecal incontinence in adults
Pericyazine for schizophrenia
Perineal techniques during the second stage of labour for reducing perineal trauma
Perioperative blood transfusions and recurrence of colorectal cancer
Peri-operative glycaemic control regimens for preventing surgical site infections in adults
Perioperative local anaesthesia for reducing pain following tonsillectomy
Perioperative transversus abdominis plane (TAP) blocks for analgesia after abdominal surgery
Peripheral iridotomy for pigmentary glaucoma
Permissive hypercapnia for the prevention of morbidity and mortality in mechanically ventilated newborn infants
Person centred counselling for psychosis
Pharmacologic interventions for treating phantom limb pain
Pharmacologic treatment for memory disorder in multiple sclerosis
Pharmacologic treatment of depression in multiple sclerosis
Pharmacologic treatment to prevent fractures in people with low bone density or osteoporosis
Pharmacological interventions for clozapine-induced hypersalivation
Pharmacological interventions for epilepsy in people with intellectual disabilities
Pharmacological interventions for the treatment of anxiety disorders in chronic obstructive pulmonary disease
Pharmacological maintenance therapy in pregnant women with an opiate dependency
Pharmacological treatment for Attention Deficit Hyperactivity Disorder (ADHD) in children with comorbid tic disorders
Pharmacological treatment for depression during opioid agonist treatment for opioid dependence
Pharmacological treatment for Kleine-Levin Syndrome
Pharmacological treatment of depression in patients with a primary brain tumour
Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain Barr? syndrome
Pharmacological treatments for fatigue associated with palliative care
Pharmacotherapy for thyroid nodules
Pharyngeal instillation of surfactant before the first breath for prevention of morbidity and mortality in preterm infants at risk of respiratory distress syndrome
Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage
Phosphate binders for preventing and treating bone disease in chronic kidney disease patients
Phosphodiasterase III inhibitors for chronic asthma
Phosphodiasterase IV inhibitors for chronic asthma
Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease
Photodynamic therapy for recurrent head and neck cancer
Photodynamic therapy using 5-ALA versus porfimer sodium for Barrett's oesophagus
Phyllanthus species for chronic hepatitis B virus infection
Physical and behavioural therapies and lifestyle modifications in the prevention of urinary incontinence in women.
Physical methods for preventing deep vein thrombosis in stroke
Physical therapy for vestibular migraine
Physical training for McArdle disease
Physiotherapy for ankylosing spondylitis
Phytotherapy versus hormonal therapy for postmenopausal bone loss
Pin site care for preventing infections associated with external bone fixators and pins
Pindolol augmentation for depression
Planned caesarean section for women with a twin pregnancy
Platinum-based chemoradiation for head and neck cancer
Polymer-based oral rehydration solution versus ORS ≤ 270 for acute watery diarrhoea
Population-based biomedical sexually transmitted infection control interventions for reducing HIV infection
Positive end expiratory pressure for preterm infants requiring conventional mechanical ventilation for respiratory distress syndrome or bronchopulmonary dysplasia
Positive end-expiratory pressure (PEEP) during anaesthesia for the prevention of mortality and postoperative pulmonary complications
Positive pressure therapy for Ménière’s disease
Posterior discectomy for lumbar disc herniations
Postoperative 5-Fluorouracil for glaucoma surgery
Post-operative therapy (splinting regimens) after metacarpophalangeal arthroplasty
Pre and post hospital Disease Management for Heart Failure
Pre-admission antibiotics for suspected cases of meningococcal disease
Prebiotics for preventing atopic eczema in infants
Pre-conception care and advice for women with diabetes
Preconception care for diabetic women for improving maternal and infant health
Preconception counselling as an influence on pregnancy planning behaviour in women with epilepsy
Predictors for the timing and intensity of anticoagulation therapy following central nervous system haemorrhage in patients with high thromboembolitic risk
Predictors of response to thiazolidinedione treatment of non-alcoholic fatty liver disease
Prednisolone for collagenous colitis
Pre-employment examinations for preventing occupational injury and disease in workers
Pre-identification services, including assessment and diagnosis and early engagement, for racial and ethnic groups with schizophrenia
Prenatal or postnatal allergen avoidance to prevent asthma
Pre-operative traction for fractures of the proximal femur in adults
Preprostatectomy pelvic floor exercises to prevent urinary incontinence.
Pressure-relieving devices for treating heel pressure ulcers
Pressurised-metered dose inhalers versus hand-held inhalers for the delivery of corticosteroids in chronic asthma
Pre-surgical orthopaedics (PSO) for infants with complete cleft lip and palate
Pre-treatment surgical para-aortic lymph node assessment in locally advanced cervical cancer
Preventative strategies to prevent foot ulcers in people with diabetes
Prevention of aminoglycoside-induced vestibular injury
Prevention of lymphoedema following surgery for breast cancer
Prevention of trismus induced by cancer therapies in head and neck cancer patients
Primary closure versus delayed closure for non bite traumatic wounds within 24 hours post injury
Probiotics (other than bifidobacterium infantis) for irritable bowel syndrome
Probiotics for maintenance of remission in ulcerative colitis
Probiotics for non-alcoholic fatty liver disease and/or steatohepatitis
Probiotics for patients with hepatic encephalopathy
Probiotics for preventing acute upper respiratory tract infections
Probiotics for preventing atopic eczema in infants at high risk for the development of atopy
Probiotics for prevention of necrotizing enterocolitis in preterm infants
Probiotics for the treatment of allergic rhinitis
Probiotics for treating established atopic eczema
Problem solving skills for schizophrenia
Progestagens and anti-progestagens for pain associated with endometriosis
Progestin-only contraceptives: effects on weight
Progressive resistance training (PRT) for improved physical function in older adults
Prolonged retreatment with pegylated interferon plus ribavirin of chronic hepatitis C non-responders to interferon plus ribavirin
Prolonged therapy with progestagens and anti-progestagens for pain associated with endometriosis
Prolotherapy injections for chronic low back pain
Promoting the mental health of carers of people with dementia
Prompted voiding for urinary incontinence
Prompted voiding, habit retraining, and timed voiding for urianary incontinence in frail older persons
Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical artery catheters
Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical venous catheters
Prophylactic antibiotics to reduce morbidity and mortality in ventilated newborn infants
Prophylactic corticosteroids for cardiopulmonary bypass in adults
Prophylactic epidural blood patch and post-dural puncture headache
Prophylactic gastrostomy tubes for head and neck cancer
Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants
Prophylactic treatment of lymph node basins in lymph node metastases from auricular squamous cell carcinoma
Prophylaxis for venous thromboembolic disease in pregnancy and the early postnatal period
Propofol for procedural sedation/anaesthesia in neonates
Propofol for sedation during colonoscopy
Propofol versus placebo for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Prostaglandin E1 for preventing the progression of diabetic kidney disease
Prostaglandin E1 for preventing the progression of diabetic kidney disease
Prostaglandins for adult liver transplanted patients
Prosthetic treatment after maxillary and mandibular reconstruction in patients with head and neck cancer
Proton pump inhibitors in acute upper gastro-intestinal bleeding
Psychodynamic psychotherapy for children with depression
Psychological and educational interventions for atopic eczema in children
Psychological and pharmacological interventions for depression in patients with coronary artery disease
Psychological and psychosocial interventions for people with schizophrenia from specific ethnic groups
Psychological and/or educational interventions for reducing alcohol consumption in pregnant women and women planning pregnancy
Psychological interventions for adults with asthma
Psychological interventions for coronary heart disease
Psychological interventions for improved quality of life in vitiligo
Psychological interventions for treating chronic pelvic pain in women
Psychological interventions for treatment of inflammatory bowel disease
Psychological therapies for irritable bowel syndrome
Psychological treatments for epilepsy
Psychologically mediated effects of the physical healthcare environment on work-related outcomes of healthcare personnel
Psychosocial interventions for premature ejaculation
Psychosocial interventions for prevention of depression in older people
Psychosocial interventions for psoriasis
Psychosocial interventions for the management of chronic orofacial pain
Psychostimulants for depression
Psychostimulants for hypersomnia (excessive daytime sleepiness) in myotonic dystrophy
Psychotherapeutic treatments for older depressed people
Psychotherapy for depression in children and adolescents
Public and professional education for continence issues
Public release of performance data in changing the behaviour of healthcare consumers, professionals or organisations
Pulsed dye laser treatment for acne
Punctal occlusion for dry eye syndrome
PUVA (oral psoralens with UVA) as a monotherapy for repigmentation in vitiligo
Quadriphasic versus monophasic oral contraceptives for contraception
Quality of life after excisional surgery with drainage and ablation of ovarian endometriomata
Quality of life after liver transplantation in female recipients
Quality of life after liver transplantation in hepatitis C virus-infected recipients
Quinine for muscle cramps
Radial optic neurotomy for central retinal vein occlusion
Radiation dose on tumor control and morbidity in the treatment of prostate cancer by 3D-CRT
Radiofrequency ablation for Barrett's oesophagus and Barrett's dysplasia
Radiofrequency ablation versus percutaneous alcohol versus acetic acid injection for hepatocelullar carcinoma
Radiofrequency ablation versus surgical resection for oligometastatic hepatic metastases of colorectal cancer
Radiofrequency ablation versus surgical resection for resectable hepatic metastases of colorectal cancer
Radiofrequency ablation versus surveillance for reduction of risk of progression to adenocarcinoma in Barrett's oesophagus
Radiofrequency catheter ablation of the pulmonary veins for treatment of atrial fibrillation
Radiofrequency thermal ablation versus other interventions for hepatocellular carcinoma
Radioiodine treatment for paediatric Graves' disease
Radiological embolisation versus surgery for pelvic congestion
Radionuclide therapy combined with liver resection for neuroendocrine tumours in patients with resectable liver metastases
Ranibizumab compared to bevacizumab (clinical effectiveness and cost effectiveness) in the treatment of exudative age-related macular degeneration (AMD)
Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries
Rapid palatal expansion effects on nasal airway dimensions as measured by acoustic rhinometry
Rate of adverse events in dialysis patients receiving interferon therapy for chronic hepatitis C versus those not on antiviral therapy
Rate of serious adverse events in antiviral treatment for chronic hepatitis C in patients with HIV
Rate of serious adverse events in small-incision or laparoscopic cholecystectomy for patients with symptomatic cholecystolithiasis
Rates of ectopic pregnancy in women with endometriosis after long term pituitary down-regulation using GnRH agonists prior to in vitro fertilisation
Reboxetine for depression
Reboxetine for depression
Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
Recombinant factor VIIa to decrease blood loss and blood transfusion requirements for liver resection
Recombinant growth hormone therapy for X-linked hypophosphatemia in children
Recombinant versus urinary gonadotrophin for ovarian stimulation in assisted reproductive technology cycles
Reconstructive Techniques After Rectal Resection for Rectal Cancer
Red cell transfusion for acute upper gastrointestinal haemorrhage
Reduced dietary salt for the prevention of cardiovascular disease
Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease
Regular toileting for urinary incontinence
Regular use of prophylactic medication for asthma
Rehabilitation exercises for chronic vertigo in primary care
Rehabilitation for ankle fractures in adults
Rehabilitation for hamstring injuries
Rehabilitation interventions for foot drop in neuromuscular disease
Rehabilitation interventions to ameliorate side effects in patients treated with chemoradiotherapy for advanced head and neck cancer
Rehabilitation programmes for schizophrenia
Rehabilitative exercises after lumbar disc surgery
Rehabilitative treatment of aphasia
Relationship between treatment and clinical outcomes in antiviral treatment for chronic hepatitis C in patients with HIV
Relative effectiveness of combined oral contraceptive pills in women compared to other acne treatments
Relaxation for depression
Relaxation techniques for pain management in labour
Relaxin for cervical ripening and induction of labour
Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma
Reminiscence groups for people with dementia and their family care-givers: pragmatic 8-centre trial of joint reminiscence and maintenance versus usual treatment
Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular surgical procedures
Repetitive transcranial magnetic stimulation for the treatment of amyotrophic lateral sclerosis or motor neuron disease
Repetitive transcranial magnetic stimulation for tinnitus
Replacement of estrogens and progestins to prevent morbidity and mortality in preterm infants
Resection versus no intervention or other surgical interventions for colorectal cancer liver metastases
Resistance exercise for walking mobility in people with multiple sclerosis
Respiratory function monitoring to reduce mortality and morbidity in newborn infants receiving resuscitation
Resveratrol and derivatives for rosacea
Rifaximin for irritable bowel syndrome
Risk factor modification to prevent acute otitis media
Risk of community-acquired pneumonia following proton pump inhibitor use
Risk of minor incontinence following anal fistula surgery with abscess drainage
Risk of osteporosis or osteopenia with depot medroxyprogesterone acetate (DMPA) in women with IBD
Risk of postoperative complications in patients with inflammatory bowel disease undergoing abdominal surgery after treatment with steroids or biological agents
Risk of progressive multifocal leukoencephalopathy after natalizumab treatment of multiple sclerosis
Risk of visual field defects in patients with refractory partial epilepsy taking vigabatrin
Risk scoring systems for predicting preterm birth with the aim of reducing associated adverse outcomes
Risk stratification for venous thromboembolic disease following elective spine surgery
Risperidone versus olanzapine for schizophrenia
Rituximab for relapsing-remitting multiple sclerosis
Robotic assisted surgery for gynaecological cancer
Role of antibiotics in facilitating post-tonsillectomy recovery
Role of antimalarial therapies in the exacerbation of psoriasis
Role of bismuth subgallate-epinephrine (BSE) paste as a hemostatic in adenotonsillectomies
Role of diet in triggering atopic eczema
Role of genetic factors in determining efficacy of clobazam and other anti-epileptic drugs in patients with refractory epilepsy
Role of ribavirin in reducing bone mineral density in chronic hepatitis C patients
Rotarix versus RotaTeq for the prevention of rotavirus diarrhoea
Rotavirus vaccination for the prevention of all-cause diarrhoea
Rotavirus vaccination for the prevention of rotavirus diarrheoa in HIV-positive children
Rotavirus vaccination for the prevention of rotavirus diarrheoa in malnorished children
Rotavirus vaccination for the prevention of rotavirus diarrheoa in preterm infants
Routine and selective invasive strategies for acute coronary syndrome
Routine follow-up or symptom-led follow-up for people with lung cancer.
Routine vitamin A supplementation for the prevention of blindness due to measles infection in children
Rubber band ligation versus excisional haemorrhoidectomy for haemorrhoids
Sacral nerve stimulation for urinary incontinence and voiding dysfunction in adults
S–adenosyl–L–methionine for alcoholic liver diseases
S-Adenosylmethionine (SAMe) for osteoarthritis of the knee or hip
Safe perioperative window of anticoagulation after spine surgery
Safety of laterally placed and laterally directed multi-needle core biopsy for diagnosing prostate cancer
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Safety of swimming in patients with chronic heart failure
Safety of topical corticosteroids in pregnancy
Safety of wet-wrap dressings with diluted topical corticosteroids, in particular 'new generation' topical corticosteroids versus established corticosteroids
Safety/tolerability and patient acceptability of low dose antipsychotic medication for people with schizophrenia
Saliva substitutes for the treatment of radiation-induced xerostomia
Salt baths for atopic eczema
Sanitary disposal of human excreta for the prevention of diarrhoea
Sargramostim (GM-CSF) for induction of remission in Crohn's disease
School–based prevention for illicit drugs' use
Sclerotherapy for lower limb telangiectasias
Scopolamine for treating motion sickness
Screening and decontamination of contacts of patients with Panton Valentine leukocidin associated Staphylococcus aureus infection
Screening for colorectal cancer using the faecal occult blood test, Hemoccult
Screening for prevention of optic nerve damage due to chronic open angle glaucoma
Screening for testicular cancer
Screening programmes for developmental dysplasia of the hip in newborn infants
Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease
Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate
Second-generation antidepressants for seasonal affective disorder
Second-generation antipsychotics for anxiety disorders
Second-generation antipsychotics for major depressive disorder and dysthymia
Second-generation antipsychotics for obsessive compulsive disorder
Segmental fasciectomy for Dupuytren’s contractures of the hand
Selective internal radiation therapy in combination with chemotherapy as front-line therapy for liver metastases from colorectal cancer
Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents
Selective serotonin reuptake inhibitors (SSRIs) in patients with depression and coronary heart disease
Selenium for preventing cancer
Selenium supplementation for critically ill adults
Selenium supplementation to prevent short-term morbidity in preterm neonates
Self-expanding metal stent insertion versus non-stent therapy or combination non-stent and stent therapy for dysphagia in oesophageal cancer
Self-management education for cystic fibrosis
Semont manuoevre for posterior canal benign paroxysmal positional vertigo
Sensory stimulation for brain injured individuals in coma or vegetative state
Septal surgery for nasal airflow
Sertraline for depression
Sertraline versus other antidepressive agents for depression
Sevoflurane versus placebo for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Shengmai (a traditional Chinese herbal medicine) for heart failure
Short acting beta2-agonists for exercise induced asthma
Short term post-operative complications after pre-operative infliximab treatment in ulcerative colitis
Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults
Should antibiotics be used orally, topically, or in combination with other treatments for acne?
Should antihistamines be used to treat anaphylaxis?
Should asthma be monitored more carefully/differently in pregnancy when compared with other adult situations?
Should GPs be allowed to manage epilepsy medication dosage?
Should GPs take an active role in the treatment of people with epilepsy?
Should I be concerned that the steroid I take for my asthma via an inhaler will cause osteoporosis and increased body weight in the long run?
Should I be more concerned about adverse effects from antipsychotic drugs with late onset of psychosis?
Should inhalers be used in people with asthma while they have a cold?
Should injections sites be varied when injecting insulin for diabetes?
Should people be discharged from A&E without somebody with a specialist interest in epilepsy reviewing their treatments?
Should potentially toxic treatments be used on a rotational basis for severe atopic eczema?
Should prophylactic antibiotics be prescribed routinely following ingrown toe nail surgery?
Should retinal assessment during pregnancy be offered to women diagnosed with gestational diabetes who are suspected of having pre-existing diabetes?
Should statins be started in children with Type 1 diabetes?
Should the nil-by-mouth rules exclude epilepsy medications?
Should treatment for heart failure with preserved ejection fraction differ from that for heart failure with reduced ejection fraction?
Should we tailor synthetic insulin doses to match pancreatic secretion to gain better symptom control
Should women with severe pre-eclampsia in the community, or in a primary care setting, be given magnesium sulphate before transfer to hospital?
Sildenafil for pulmonary hypertension in neonates
Sildenafil for pulmonary hypertension in neonates
Simple behavioural interventions for nocturnal enuresis in children
Simulator based rehabilitation for chronic dizziness
Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain
Single dose oral fenoprofen for acute postoperative pain in adults
Single dose oral mefenamic acid for acute postoperative pain in adults
Single incision versus conventional multi-incision appendicectomy for suspected appendicitis
Single inhalers containing corticosteroid and long-acting bronchodilator for chronic asthma in adults and children
Single layer versus double layer suture anastomosis of the gastrointestinal tract
Single-agent interleukin-2 in the treatment of metastatic melanoma
Sinomenine for rheumatoid arthritis
Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion
Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants
Smoking cessation and nicotine replacement therapy in COPD patients.
Social skills training for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 5 to 18 years
Somatostatin analogues for pancreatic surgery
Sorafenib for cholangiocellular carcinoma
Sound therapy for tinnitus
Special diets for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Specialised antenatal clinics for women with a pregnancy at high risk of preterm birth (excluding multiple pregnancy) to improve maternal and infant outcomes
Specialised clothing for reducing or preventing atopic eczema
Specialist continence clinics in the community.
Specialist nursing interventions for inflammatory bowel disease
Specific adverse drug reactions resulting from the combination of methotrexate with phototherapy for psoriasis
Speech and language therapy for aphasia following stroke
Speech and language therapy for dysarthria
Speech and language therapy for receptive language difficulties in children with primary speech and language delay
Speech and language therapy to improve the communication skills of children with cerebral palsy
Speleotherapy for asthma
Sphenopalatine artery ligation for epistaxis
Sphincterotomy for biliary sphincter of Oddi dysfunction
Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin
Spinal endoscopic adhesiolysis for post lumbar surgery syndrome
Spinal manipulation for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Spinal manipulative therapy for chronic low-back pain
Spironolactone for treatment of acne in women
Spironolactone in diabetic nephropathy
Sponge versus diaphragm for contraception
St John's Wort for Depression
St John's wort for major depression
Stability after bilateral sagittal split osteotomy advancement surgery with rigid internal fixation
Stainless-steel alloy versus nickel-titanium alloy endoscopic palliative biliary stents for obstructing pancreatic carcinoma
Standard home alarm clock for nocturnal enuresis
Starting dose of levothyroxine for the treatment of congenital hypothyroidism
Statins for acute coronary syndrome
Statins for acute ischemic stroke
Statins for chronic heart failure (CHF)
Statins for multiple sclerosis
Statins for multiple sclerosis
Statins for primary prevention of venous thromboembolism
Statins for women with polycystic ovary syndrome not actively trying to conceive
Statins to prevent melanoma and non melanoma skin cancer.
Stem cell transplantation for ischemic stroke
Stereotactic radiosurgery for acoustic neuroma
Steroid drops for otitis externa
Steroids for improving recovery following tonsillectomy in children
Steroids in the treatment of vestibular neuronitis
Stiripentol for treating difficult seizures other than in SMEI
Strategies for the withdrawal of nasal continuous positive airway pressure (NCPAP) in preterm infants
Stretch for the treatment and prevention of contractures
Structured treatment interruptions (STI) in chronic suppressed HIV infection in adults
Sublingual immunotherapy for treating allergic conjunctivitis
Suction blister grafts for repigmentation in vitiligo
Sulphasalazine for psoriasis
Sultopride for schizophrenia.
Sun-protective behaviors and reduced Vitamin D levels, with increases in diseases hypotheszied to be affected by Vitamin D
Supplementary pelvic floor exercises with electromyographic or manometric biofeedback.
Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development
Support surfaces for treating pressure ulcers
Supportive therapy for schizophrenia
Surgery for acute fractures or non-union of the third middle of the clavicle
Surgery for cervical radiculopathy and myelopathy
Surgery for cervical radiculopathy or myelopathy
Surgery for chronically discharging ears with underlying eardrum perforations
Surgery for lateral elbow pain
Surgery for long-term resistant epilepsy
Surgery for lumbar disc prolapse
Surgery for Ménière's disease
Surgery for rotator cuff disease
Surgery for stress urinary incontinence due to presumed sphincter deficiency after prostate surgery
Surgery for thumb osteoarthritis
Surgery for tympanic membrane retraction pockets
Surgery for vocal cord paralysis and paresis
Surgery using LARS techniques versus proton pump inhibitors alone for prevention of adenocarcinoma in Barrett's oesophagus
Surgery using LARS techniques versus proton pump inhibitors alone for prevention of Barrett's oesophagus
Surgery using LARS techniques versus proton pump inhibitors alone for regression of Barrett's oesophagus
Surgery versus conservative treatment for odontoid fractures
Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus
Surgery, such as bladder augmentation, for intractible incontinence
Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea
Surgical interventions for adults with anterior shoulder instability
Surgical interventions for diaphyseal fractures of the radius and ulna in children
Surgical interventions for nasal polyps
Surgical interventions for pharyngeal pouch
Surgical interventions for the early management of Bell's palsy
Surgical interventions for treating chronic pelvic pain in women
Surgical management for upper urinary tract transitional cell carcinoma
Surgical orbital decompression for thyroid eye disease
Surgical repair of spontaneous perineal tears that occur during childbirth versus no intervention
Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases
Surgical resection versus non-surgical treatment for hepatic node positive patients with colorectal liver metastases
Surgical techniques other than Botox injection for spasmodic dysphonia
Surgical versus non-surgical interventions for treating humeral shaft fractures in adults
Surgical versus non-surgical interventions for treating patellar dislocation
Surgical versus non-surgical interventions for vocal cord nodules
Swallowing outcomes after radiotherapy for head and neck cancer
Swapping or sharing of audio signals between bilaterally fitted hearing aids
Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years
Symptom based plans for the care of people with asthma – which ones and are they the same for all groups?
Symptomatic versus prophylactic antibiotic therapy for the reduction of urinary tract infections in patients with neurogenic bladder dysfunction using intermittent self-catheterisation
Systematic review of periodontal plastic surgery in the treatment of multiple recession-type defects
Systematic review of the effectiveness of botulinum toxin or radiotherapy for sialorrhea in patients with amyotrophic lateral sclerosis
Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults
Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations
Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy
Systemic chemotherapy versus radiofrequency ablation plus systemic therapy for liver-predominant hepatic metastases of colorectal cancer
Systemic corticosteroids for acute gout
Systemic corticosteroids for acute sinusitis
Systemic corticosteroids for atopic eczema
Systemic drug treatment plus topical vitamin D derivatives for psoriasis
Systemic Family Therapy for children with depression
Systemic therapy for treating locoregional recurrence in women with breast cancer
Systemic treatments for metastatic cutaneous melanoma
Tacrolimus for induction of remission in refractory ulcerative colitis
Tai Chi for depression
Tai Chi for Meniere's disease
Tai chi for osteoporosis
Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults
Targeted broad band UVB for repigmentation in vitiligo
Targeted drug therapies for the management of metastatic colorectal cancer
Tea tree oil for acne
Teaching cognitive psychology/psychotherapy to people with schizophrenia
Techniques for the interruption of tubal patency for female sterilisation
Telehealthcare for chronic obstructive pulmonary disease
Teratogenic risks of individual anti-epileptic drugs
Terbutaline pump maintenance therapy after threatened preterm labour for preventing preterm birth
Teriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis
Testosterone for schizophrenia
Thalidomide analogues for induction of remission in Crohn's disease
Thalidomide analogues for maintenance of remission in Crohn's disease
The additional benefit of oral contraceptive pills containing cyproterone acetate for acne
The advantages of metformin in terms of cardiovascular outcomes
The best method for managing epilepsy in adults with intellectual disability
The best method for protein Z measurement
The clinical significance of resistance to P. acnes with topical antimicrobial use
The effect of adding inhaled corticosteroids to tiotropium and long-acting beta2-agonists for chronic obstructive pulmonary disease
The effect of financial incentives on the quality of health care provided by primary care physicians
The effect of oxytocin antagonists for inhibiting preterm labour on fetal outcome
The effect of shift work on the control of diabetes
The effectiveness and safety of combined treatment with angiotensin antagonist and ace inhibitors for people with diabetes
The effects of anaesthetic agents on cortical mapping during neurosurgical procedures involving eloquent areas of the brain
The effects of antibiotic treatments on type 2 diabetes and metabolic disorder
The effects of long term pituitary down-regulation using GnRH agonists before in vitro fertilisation for women with endometriosis on the incidence of pregnancy complications
The efficacy of ablation versus excision versus laser versus diathermy surgery for subfertility associated with severe endometriosis
The impact of malocclusion/orthodontic treatment need on the quality of life
The impact of targeted drug therapies on current management of metastatic colorectal cancer
The impact of user fees on access to health services in low- and middle-income countries
The influence of tobacco smoking on the outcomes achieved by root-coverage procedures
The potential harms or costs of intensifying follow up for non-metastatic colorectal cancer patients
The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) Trial with depression
The role of case registers in the long term management of people with schizophrenia in general practice
The role of continuing a sulphonylurea when starting premixed insulin
The role of non-pharmacological treatments in behavioural control as an alternative to rapid tranquillisation for schizophrenia
The role of self-monitoring of blood glucose (SMBG) as part of an integrated package, along with patient education and therapies, used to target type 2 diabetes
The use of mecophenolate mofetil (MMF) in the treatment of IgA nephropathy
Theory-based interventions for contraception
Therapeutic improvement of Eustachian tube function
Therapeutic touch for Ocular Hypertension (OHT) and Chronic Open Angle Glaucoma (COAG)
Therapeutic ultrasound for carpal tunnel syndrome
Therapies for ocular metastases of melanoma
There is a lack of stability of asthma symptoms in children under two. What treatment would be best?
There is a need for accurate, continuous, non-invasive blood glucose monitoring in diabetes– how can we achieve this?
Thiazide diuretics and the risk of hip fracture
Thin split-thickness grafts for repigmentation in vitiligo
Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion
Thromboprophylaxis strategies for multiple myeloma patients undergoing immunomodulatory therapy with thalidomide or lenalidomide
Thymic peptides for treatment of cancer patients
Thymopentin for atopic eczema
Tight control of mild-moderate pre-existing or non-proteinuric gestational hypertension
Timing of breast surgery in premenopausal breast cancer patients
Timing of dornase alfa inhalation for cystic fibrosis
Timing of tracheostomy in trauma patients
Tinnitus retraining therapy
Tiotropium plus formoterol vs tiotropium alone in patients with stable COPD
To minimise selective pressure, would it be helpful to use benzoyl peroxide concomitantly whenever antibiotics are prescribed and, if so, would short washouts (say one week in four) suffice?
To what extent are individuals with trimethylaminuria, and lack functional hepatic flavin containing monooxygenase 3 (FMO3) substrates, unable to oxidize other odiferous FMO3-specific substrates and does this contribute significantly to body odour?
Tobacco smoking cessation for treating acne
Tocilizumab for rheumatoid arthritis
Tocolytics for preterm premature rupture of membranes
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA)
Tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis
Topical agents and dressings for fungating wounds
Topical anaesthetic or vasoconstrictor preparations for flexible fibre-optic nasal pharyngoscopy and laryngoscopy
Topical analgesia for acute otitis media
Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis
Topical anti-oxidant and mitochondrial stimulating cream (VitilVenz) for repigmentation in vitiligo
Topical calcipotriol plus photochemotherapy (oral 8-MOP) for repigmentation in vitiligo
Topical calcipotriol plus UV light for repigmentation in vitiligo
Topical dapsone for acne
Topical glyceryl trinitrate for rotator cuff disease
Topical glycolic acid for acne
Topical human placental extract (melagenina) for repigmentation in vitiligo
Topical interventions for genital lichen sclerosus
Topical khellin combined with UVA compared to UVA alone for repigmentation in vitiligo
Topical lactic acid plus UVA for repigmentation in vitiligo
Topical nasal steroids for intermittent and persistent allergic rhinitis in children
Topical nasal steroids for treating nasal polyposis in people with cystic fibrosis
Topical phosphodiesterase inhibitors for atopic eczema
Topical pimecrolimus as monotherapy for repigmentation in vitiligo
Topical pimecrolimus compared to mild corticosteroids for atopic eczema
Topical pimecrolimus plus narrow band UVB for repigmentation in vitiligo
Topical plant–based catalase/dismutase for repigmentation in vitiligo
Topical pseudocatalase cream plus UVB for repigmentation in vitiligo
Topical psoralea tincture for repigmentation in vitiligo
Topical psoralens with sunlight (topical PUVAsol) for repigmentation in vitiligo
Topical retinoids compared to benzoyl peroxide for acne
Topical retinoids versus antimicrobial-based regimens for acne
Topical steroid for chronic rhinosinusitis without polyps
Topical steroids for repigmentation in vitiligo
Topical tacalcitol plus 308nm excimer laser for repigmentation in vitiligo
Topical tacalcitol plus narrow band UVB for repigmentation in vitiligo
Topical tacalcitol plus sunlight for repigmentation in vitiligo
Topical tacrolimus as monotherapy for repigmentation in vitiligo
Topical tacrolimus plus 308nm excimer laser for repigmentation in vitiligo
Topical tacrolimus plus UV light for repigmentation in vitiligo
Topical treatments for HIV-related oral ulcers
Topical treatments for nail psoriasis
Topiramate for vestibular migraine
Total fasciectomy for Dupuytren’s contractures of the hand
Toxicity reduction strategies in postoperative chemoradiotherapy for advanced squamous cell carcinoma of the head and neck
TPO receptor agonist for chronic idiopathic thrombocytopenic purpura
Traction for low back pain with or without sciatica
Traditional Chinese medicine as a concomitant therapy for nasopharyngeal carcinoma
Traditional Chinese medicine for epilepsy
Traditional Chinese medicines for chronic hepatitis B
Training to recognise the early signs of recurrence in schizophrenia
Tranexamic acid for epistaxis
Tranexamic acid for upper gastrointestinal bleeding
Tranexamic acid to decrease blood loss and blood transfusion requirements for liver resection
Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma
Transcranial magnetic stimulation for schizophrenia
Transcranial magnetic stimulation for tinnitus
Transcutaneous electric nerve stimulation (TENS) in the treatment of pain in neurologic disorders
Transcutaneous electrical nerve stimulation (TENS) for low back pain
Transcutaneous electrical nerve stimulation for acute pain
Transforaminal epidural steroid injections for low back pain
Transmyocardial laser revascularization versus medical therapy for refractory angina
Transobturator foramen procedures for stress incontinence
Transoral laser versus conventional surgery for the treatment of oral and oropharyngeal cancers
Transparent cap colonoscopy versus standard colonoscopy for investigation of gastrointestinal tract conditions
Transplacental versus direct fetal corticosteroid treatment for accelerating fetal lung maturation where there is a risk of preterm birth
Transtheoretical model for dietary and physical exercise modification in weight loss management for overweight and obese adults
Transverse colostomy versus ileostomy for temporary decompression of colorectal and coloanal anastomosis
Transverse verses midline incisions for abdominal surgery
Treadmill interventions with partial body weight support in children under six years of age at risk of neuromotor delay
Treadmill training for patients with Parkinson's disease
Treating asymptomatic bacteriuria for incontinence
Treatment and follow-up of oral dysplasia
Treatment compliance in ulcerative colitis patients treated with MMX mesalamine
Treatment delivery using information and communication technology for people with schizophrenia
Treatment duration and optimal dose of terlipressin therapy in Type 1 hepatorenal syndrome (HRS)
Treatment duration for bevacizumab in metastatic colorectal cancer
Treatment for adverse effects of anti-epileptic medications
Treatment for familial amyotrophic lateral sclerosis/motor neuron disease
Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis)
Treatment for inhalant dependence and abuse
Treatment for Lambert-Eaton myasthenic syndrome
Treatment for meralgia paraesthetica
Treatment for postpolio syndrome
Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
Treatment for ulnar neuropathy at the elbow
Treatment of acute bacterial rhinosinusitis
Treatment of antenatal depression using interventions other than pharmacological, psychological or psychosocial ones
Treatment of bruxism in children
Treatment of constipation on the number of urinary incontinence episodes in frail elderly people
Treatment of Lennox-Gastaut syndrome
Treatment of obstructive sleep apnoea for chronic cough in children
Treatment of sleep-related epilepsy
Treatment of the clinically node-negative neck in primary parotid carcinoma
Treatment of urinary incontinence after stroke in adults
Treatment of valvular heart disease during pregnancy for improving maternal and neonatal outcome
Treatments for basal cell carcinoma
Treatments for breast engorgement during lactation
Treatments for constipation in children and young adults undergoing cancer treatment
Treatments for depression/anxiety for patients with heart failure
Treatments for gestational diabetes
Treatments for gestational diabetes and impaired glucose tolerance in pregnancy
Treatments other than antibiotics for acute sore throat
Trials are needed that address the difference between technical blood glucose control in the laboratory and real life experience of blood glucose strips for people with diabetes
Triamcinolone for chronic asthma
Tricyclic drugs for depression in children and adolescents
Trimetazidine for adult chronic heart failure patients
Trimetazidine for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
True level of efficacy of ciclosporin for psoriasis
Tryptophan and 5-Hydroxytryptophan for depression
Tumor necrosis factor-alpha antibody for early Crohn's disease
Tumor necrosis factor-alpha antibody for maintenance of remission of Crohn's disease in paediatric patients
Tumor necrosis factor-alpha antibody for maintenance of remission of Crohn's disease in pregnant patients
Types of anti-oxidant multivitamin supplements used to slow or prevent progression of age-related macular degeneration important
Tyrosine supplementation for phenylketonuria
Ulinastatin versus placebo for ischaemia reperfusion injury sustained during elective liver resections under vascular occlusions
Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer
Ultrasonography or PET-CT in the staging and surveillance of melanoma patients
Ultrasound use for the placement of haemodialysis catheters
Ultraviolet treatment compared to oral immunomodulatory treatment for severe atopic eczema
Unfractionated heparin compared with compression therapy for deep vein thrombosis (DVT) prophylaxis.
Universal family-based prevention programs for alcohol misuse in young people
Universal multi-component prevention programs for alcohol misuse in young people
Universal school-based prevention programs for alcohol misuse in young people
Ursodeoxycholic acid for cystic fibrosis-related liver disease
Use of a closed loop system to control diabetes
Use of cervical assessment by ultrasound in pregnant women to prevent preterm birth
Use of EEG as standard practice in the monitoring of effective treatment in neonatal seizures
Use of electronic health records to support smoking cessation
Use of statins in dialysis patients
Use of statins in kidney transplant patients
Use of statins in patients with chronic kidney disease
Using alternative statistical formats for presenting risks and risk reductions
Uterine muscle relaxant drugs for threatened miscarriage
Utero-placental Doppler ultrasound for improving pregnancy outcome
Utility, acceptability and safety of available drugs for urgent sedation (including atypical antipsychotics) for psychosis
UVA monotherapy for repigmentation in vitiligo
UVB phototherapy plus emollients compared to UVB alone for psoriasis
Vaccination for preventing postherpetic neuralgia
Vaccines for preventing influenza in people with cystic fibrosis
Vaccines for prophylaxis of viral infections in patients with hematological malignancies
Vaccines to prevent acute otitis media in children
Vaginal dilator therapy for women receiving pelvic radiotherapy
Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults
Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss
Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss
Venlafaxine for depression
Veno-venous bypass versus none for liver transplantation
Vestibular rehabilitation exercises for chronic dizziness
Vestibular rehabilitation for unilateral peripheral vestibular dysfunction
Vigabatrin versus carbamazepine monotherapy for epilepsy
Virtual reality for stroke rehabilitation
Vitamin A for the prevention of diarrhoea in children with HIV infection or exposure to maternal HIV infection
Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age
Vitamin B for schizophrenia
Vitamin B1 for primary and secondary dysmenorrhoea
Vitamin C and selenium for rheumatoid arthritis
Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
Vitamin D for multiple sclerosis
Vitamin D for the management of multiple sclerosis
Vitamin D supplementation for prevention of mortality in adults
Vitamin E for age-related macular degeneration to slow distance visual acuity change or progression
Vitamin E for neuroleptic-induced tardive dyskinesia
Vitamin K for upper gastrointestinal bleeding in patients with liver diseases
Vitamin K prior to preterm birth for preventing neonatal periventricular haemorrhage
Vitamin supplements (including B12, vitamin C and folic acid) for repigmentation in vitiligo
Vocational rehabilitation for persons with multiple sclerosis
Warfarin therapy for non-atrial fibrillation heart failure
Water softeners for atopic eczema
Water-based exercise programmes for the treatment of mild multiple sclerosis
Weight loss for non-alcoholic fatty liver disease
What actions should I take to help my asthma symptoms associated with my menstrual cycle?
What alternatives are there for treating asthma other than medication?
What are my future treatment options for my schizophrenia when the medicine has not helped?
What are patient beliefs regarding concordance with prescribed treatments and complementary therapies in adults with psoriasis and psoriatic arthritis?
What are relative advantages and disadvantages of different isomers of salbutamol?
What are the advantages and disadvantages of a flutter device for asthma medication in combination with carbocisteine 375 x 3 day to stop or reduce mucus formation?
What are the advantages and disadvantages of breath-actuated inhalers compared with traditional inhalers?
What are the advantages and disadvantages of complementary treatments for asthma?
What are the advantages and disadvantages of nebulisers vs spacers for asthma?
What are the advantages and disadvantages of the new smaller salbutamol inhaler compared with the older larger salbutamol inhalers?
What are the advantages referral to a specialist for asthma?
What are the adverse effects associated with the long term-use of long-acting bronchodilators?
What are the adverse effects associated with the long term-use of short-acting bronchodilators for adults and children?
What are the adverse effects associated with the long-term use of combination and additive therapies for asthma?
What are the adverse effects associated with the long-term use of inhaled steroid therapies?
What are the adverse effects associated with the long-term use of oral steroid therapies?
What are the adverse effects associated with the long-term use of steroid drug therapies for asthma in children?
What are the benefits and harms of immunosuppressive regimens containing TOR-I when compared to other regimens as initial therapy for kidney transplant recipients?
What are the benefits and harms of phosphate binders in chronic kidney disease (CKD)?
What are the benefits and optimum structure of rehabilitation programmes in adults with testicular germ cell tumours?
What are the benefits of adjuvant drugs in pemphigus?
What are the benefits of breathing exercise as a form of physical therapy for asthma?
What are the benefits of continuing to use medication, over experiencing side-effects for children with mild asthma?
What are the benefits of different surgical procedures for epilepsy?
What are the benefits of disposable insulin pens vs. non disposable insulin pens?
What are the benefits/harm of running higher glycaemic control to reduce long term adverse events?
What are the best forms of insulin for treating type 1 diabetes?
What are the best injection sites for delivering insulin for diabetes?
What are the best interventions to improve balance/minimise symptoms in daily activities such as supermarkets, escalators etc.?
What are the best methods of remembering to take epilepsy medication?
What are the best patient reported outcomes to monitor treatment for pernicious anaemia?
What are the characteristics of the best type 1 diabetes patient education programmes (from diagnosis to long term care) and do they improve outcomes?
What are the cognitive and psychological effects of living with type 1 diabetes?
What are the costs of chronic heart disease screening for patients with psoriasis?
What are the effects of two compounds of betamethasone dipropionate 0.05% plus calcipotriol ointment with clobetasol propionate 0.05% ointment on psoriasis and psoriatic arthritis?
What are the effects of adrenoceptor agonists for women with stress incontinence?
What are the effects of alternate day (once daily) calcipotriol 50 mcg/g ointment and either clobetasol propionate 0.05% ointment or betamethasone dipropionate 0.05% ointment with once daily two compound (calcipotriol 50 mcg/g combined with betamethasone dipropionate 0.05%) ointment on adults with psoriasis and psoriatic arthritis?
What are the effects of annual review of asthmatic patients by telephone?
What are the effects of antiepileptic drugs on gums?
What are the effects of antiepileptic drugs on teeth?
What are the effects of antiepileptic drugs on the liver?
What are the effects of antipsychotic drugs and/or psychological interventions in early onset schizophrenia?
What are the effects of antipsychotic drugs on children with early symptoms of schizophrenia?
What are the effects of breathing exercises in asthma?
What are the effects of Bricanyl infusion compared to alternatives for asthma?
What are the effects of complementary therapies for schizophrenia?
What are the effects of epilepsy medications on female fertility?
What are the effects of individual anti-epileptic drugs on a developing child?
What are the effects of routine screening for proteinuria (testing urine for protein) in healthy pregnant women?
What are the effects of short contact dithranol and coal tar solution on psoriasis and psoriatic arthritis?
What are the effects of stress on glucose levels in people with type 1 diabetes?
What are the effects on the incidence of pre-eclampsia of progesterone given to prevent preterm birth?
What are the exact mechanisms involved in anti-epileptic drug (AED) induced teratogenesis?
What are the family characteristics that promote success in the treatment of child and adolescent obesity?
What are the gender differences in side effects from anti-epileptic drugs?
What are the healthcare preferences and unmet needs of people with psoriasis and psoriatic arthritis in Scotland?
What are the hormonal differences in side effects from anti-epileptic drugs?
What are the impacts of different anti-epileptic drugs on children after birth?
What are the indications for discontinuing medication in patients with schizophrenia?
What are the information needs of patients with psoriasis and psoriatic arthritis in terms of timing (at initial diagnosis, when changing from one treatment to another), method (one-to-one session, written information booklet, online), and setting (GP consultation, practice nurse consultation dermatology/rheumatology consultation, nurse specialist consultation, occupational health consultation)
What are the information needs of psoriatic arthritis patients in terms of information and education, Quality of Life issues, psychosocial support, involvement in care and patient satisfaction?
What are the key components of successful ‘Self-management’ for a person with asthma?
What are the long term adverse effects of inhalers used to treat asthma?
What are the long term adverse effects of medication for asthma?
What are the long term adverse effects of methotrexate tablets when taken for psoriatic arthritis?
What are the long term adverse effects of steroids for asthma?
What are the long term adverse effects of steroids for asthma?
What are the long term adverse effects of steroids for asthma?
What are the long term adverse effects on adults who are on potent to very potent topical corticosteroids for psoriasis and psoriatic arthritis?
What are the long term adverse metabolic effects of antipsychotic medication?
What are the long term effect of prescribed drugs for asthma?
What are the long term effects of combined steroid and beta-2 agonist inhalers on the voice?
What are the long term effects of Deep Brain Stimulation (DBS) in patient with a mental health problem?
What are the long term effects of inhaled steroids for asthma?
What are the long term effects of inhaled steroids for asthma?
What are the long term effects of inhaling steroids for asthma?
What are the long term effects of medication for asthma in children?
What are the long term effects of medication for asthma?
What are the long term effects of medication for asthma?
What are the long term effects of medication for asthma?
What are the long term effects of over medication for asthma?
What are the long term effects of repeated short courses of steroid tablets in children with asthma?
What are the long term effects of salbutamol inhalers for asthma in children?
What are the long term effects of steroids for asthma in children?
What are the long term effects of steroids for asthma?
What are the long term effects of steroids for asthma?
What are the long term effects of steroids I take for asthma?
What are the long term effects of steroids used to treat asthma?
What are the long term effects of taking Beta2-adrenergic receptor agonists for asthma?
What are the long term effects of taking medication for asthma?
What are the long term effects of taking medication for asthma?
What are the long term effects of taking steroids for asthma?
What are the long term effects of taking steroids for asthma?
What are the long term effects of taking steroids for asthma?
What are the long term effects of taking steroids for asthma?
What are the long term effects of the leukotriene receptor antagonists I take for asthma?
What are the long term effects of the steroids I take for asthma?
What are the long term effects of the steroids I take for asthma?
What are the long term effects of treating seizures in babies versus not treating?
What are the long term effects of using high doses of steroids used to treat asthma?
What are the long term effects of using inhalers for asthma?
What are the long term effects of using inhalers to treat asthma?
What are the long term effects of using medication to treat asthma and are they reversible?
What are the long term effects of using medication to treat asthma?
What are the long term effects of using preventor inhalers to treat asthma?
What are the long term effects of using steroids for asthma?
What are the long term effects of using steroids for asthma?
What are the long term effects of using steroids to treat asthma?
What are the long term effects on a young child of taking steroids for asthma?
What are the long term harmful effects of steroid inhalers started during childhood?
What are the long term harmful effects of steroid inhalers started during childhood?
What are the long term side affects of tranquillizers taken with antypsychotics in the treatment of schizophrenia?
What are the long term side effects of asthma medications?
What are the long term side effects of steroids for asthma?
What are the long term side effects on growth (height + feet) of treating asthma in children with steroid inhalers?
What are the long-term adverse effects of continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus?
What are the long-term complication rates associated with the various forms of insulin used to treat diabetes?
What are the long-term effects of aldosterone antagonists for preventing the progression of chronic kidney disease?
What are the long-term effects of inhalers (e.g. Becotide/Ventolin) used on babies and toddlers?
What are the long-term effects of taking isotretinoin for acne? In particular, if it raises cholesterol so significantly during the course of treatment, is there any evidence to show future problems linked to this?
What are the long-term risks associated with epilepsy surgery?
What are the minimum requirements of successful Patient Education / Self-Management programme for the care of people with asthma, (In terms of resources / practical issues)? Are they the same for all groups?
What are the most cost- and resource-effective methods of treating child and adolescent obesity in different health care settings?
What are the most effective catheter type, placement and insertion techniques for preventing peritonitis in peritoneal dialysis patients?
What are the most effective treatment protocols for women with stress, urge or mixed urinary incontinence and an inability to voluntarily contract pelvic floor muscles?
What are the most effective treatments of daytime urinary incontinence in children?
What are the most effective types of continence services for people with urinary incontinence
What are the optimal pelvic floor muscle training protocols (frequency and duration of therapy) for the treatment of different patterns of urinary incontinence?
What are the potential harms as well as benefits of different interventions for weight reduction?
What are the potential long term effects of using steroids for asthma?
What are the psychosexual and gonadal functions in men following treatment for testicular germ cell tumours?
What are the psycho-social implications for young children with diabetes, of needing others to administer injections during the school day?
What are the relative advantages and disadvantages of Seretide 50 and Seretide 250? Will the higher dose cause problems for my very sensitive skin?
What are the relative merits and demerits of the combination inhalers Symbicort and Seretide in managing chronic asthma in adults?
What are the risks and benefits associated with analgesia and anaesthesia in women with diabetes?
What are the risks of different surgical procedures for epilepsy?
What are the safety and efficacy of surgical treatments for posterior canal BPPV?
What are the side effects of steroids taken for treatment of asthma?
What can be done to delay or prevent the onset of hormone independent prostate cancer?
What can we do to improve treatment of people with epilepsy in A&E departments?
What catheter regimens are most effective in preventing urinary tract infections in patients using intermittent self-catheterisation for the management of a neurogenic bladder?
What clinical and patient characteristics determine the effectiveness and acceptability of conservative and surgical strategies for the management of neurogenic bladder following spinal cord injury?
What clinical and patient characteristics determine the effectiveness and acceptability of treatment and management strategies for neurogenic bladder dysfunction in multiple sclerosis?
What clinical and patient characteristics determine the effectiveness and acceptability of treatment and management strategies for neurogenic bladder dysfunction in spina bifida?
What effect do steroid inhalers have on the body given that I take oral steroids two or three times a year for short periods?
What effect does exercise have on blood pressure and the incidence of pre-eclampsia?
What effective models of home phototherapy are there for adults with psoriasis and psoriatic arthritis?
What effects do anti-epileptic drugs have during pregnancy on the child?
What effects do anti-epileptic drugs have during pregnancy on the child?
What evidence is there that complementary therapies can reduce asthma severity?
What evidence is there to support the present recommendations of a high carbohydrate diet for the treatment of Type 1 and Type 2 diabetes?
What family caregiver characteristics improve the effect of behavioral interventions for urinary incontinence?
What impact do changing hormones, for example during menstruation, pregnancy and menopause, have on blood glucose levels in women with type 1 diabetes?
What impact does psoriatic arthritis have on activities of daily living?
What interventions are effective in preventing Ménière's disease going to the second ear?
What interventions are most effective at different levels of obesity severity and at different ages and developmental stages?
What interventions are most effective for specific ethnicities, religious groups or culturally diverse populations for weight reduction
What is best practice for the treatment of combined stress urinary incontinence and detrusor overactivity?
What is the benefit of incretin therapy for the treatment of type 1 diabetes?
What is the benefit of Transcranical Magnetic Stimulation (TMS) for schizophrenia?
What is the best choice of steroid, dose and number of injections for local injection in the treatment of carpal tunnel syndrome?
What is the best format to deliver patient information for improving management, self care and adherence with treatment in patients with atopic eczema.
What is the best post-surgical care for people with epilepsy?
What is the best therapy for renoprotection - ACEi or ARBs - and what is the role of combination therapy?
What is the best treatment for adult testicular germ cell tumours?
What is the best treatment for the residual hearing loss and tinnitus in end-stage (no vertigo attacks) Ménière's disease?
What is the best treatment to produce rapid recovery of balance following a Ménière's attack?
What is the best way of cleaning the aerochamber device used with ventolin inhalers?
What is the best way of dealing with allergies to cats & dogs to prevent asthma?
What is the best way of responding, in the short term, to severe challenging behaviour and agitation in relation to the use of anti-psychotics in schizophrenia?
What is the best way of training health professionals in the management of balance disorders?
What is the best way or method to administer thromboprophylaxis during pregnancy and the puerperium?
What is the best way to counter an asthma attack if you do not have your medication available?
What is the best way to monitor tissue cell function when a patient is taking any of the forms of B12 for classic pernicious anaemia?
What is the best way to promote adherence with emollient and topical corticosteroid therapies for adults with atopic eczema?
What is the best way to teach professionals about caring for people with asthma?
What is the best way to treat febrile seizures?
What is the best way to treat people with schizophrenia un-responsive to treatment?
What is the best way, for people with type 1 diabetes, to manage thier weight?
What is the cardiovascular risk, and safety of non-steroidal anti-inflammatory drugs in adults with psoriasis and psoriatic arthritis?
What is the clinical and cost effectiveness of different monitoring intervals for detection of disease progression in Chronic Open Angle Glaucoma patients at risk of progression?
What is the clinical and cost effectiveness of providing glaucoma patients with a ‘glaucoma card’ or individual record of care compared to standard treatment?
What is the comparative effectiveness of conservative treatments for bladder control problems following prostate surgery?
What is the comparative efficacy and safety of leflunomide, sulfasalazine and methotrexate for psoriatic arthritis, in doses regularly used in current practice?
What is the correct needle length for injecting insulin for diabetes?
What is the cost and benefit of new imaging modalities for rheumatoid arthritis?
What is the current evidence concerning anti-epileptic drugs effect on bones?
What is the determination of the phototherapy action spectrum in adults with psoriasis and psoriatic arthritis?
What is the direct effect on health-related quality of life associated with weight loss, or of avoiding weight gain, for people with type 2 diabetes?
What is the duration of the course of antibiotics used to treat acute pyelonephritis in children?
What is the effect of adding a progestagen to oestrogen therapy in post-menopausal women with an intact uterus who have urinary incontinence?
What is the effect of anti tumour necrosis factor therapy on the ability of people with rheumatoid arthritis to remain in employment?
What is the effect of antipsychotic medication on people with learning disability?
What is the effect of early intervention in psoriasis and psoriatic arthritis with disease-modifying anti-rheumatic drugs on incidence of comorbidity, joint damage and disability, compared to late intervention?
What is the effect of land-based physical exercise on pain and physical function in osteoarthritis of the hip?
What is the effect of resistance training for knee osteoarthritis on arthritis symptoms, physical performance and psychological function?
What is the effectiveness and cost-effectiveness of initial argon, diode or selective laser trabeculoplasty treatment compared to PGA alone or laser + PGA in combination in COAG patients?
What is the effectiveness and safety of prophylactic antibiotic therapy for the prevention of urinary tract infections in patients using intermittent self-catheterisation for the management of a neurogenic bladder?
What is the effectiveness of anti-embolism stockings in non-stroke medical patients?
What is the effectiveness of different routes of oestrogen therapy administration in post-menopausal women with urinary incontinence?
What is the effectiveness of duration of oestrogen therapy treatment in post-menopausal women with urinary incontinence?
What is the effectiveness of full and knee length anti-embolism stockings in non-stroke patients?
What is the effectiveness of new treatments for prostate cancer such as High Intensity Focused Ultrasound (HIFU) and Cryotherapy?
What is the efficacy of patient self-administered Semont manoeuvre or canalith repositioning procedure for benign paroxysmal positional vertigo?
What is the evidence for gargling aspirin as an analgesic for sore throat?
What is the evidence for heliox in the immediate treatment of acute asthma?
What is the evidence for increasing the dose of inhaled steroids in a mild asthma exacerbation?
What is the evidence for leukotriene receptor antagonists in the immediate treatment of acute asthma?
What is the evidence for magnesium sulphate in the immediate treatment of acute asthma?
What is the evidence for using natural progesterone in treatment of hair loss on perimenopausal woman? Also which hormone replacement treatment might help?
What is the evidence for using SSRI's (antidepressant medication) for the treatment of menopausal flushing?
What is the experience for patients of drug treatments, both conventional and atypical antipsychotics, for schizophrenia?
What is the impact of family interventions on the symptoms of schizophrenia?
What is the impact of working or stress for a pregnant women who has increased blood pressure that has not reached the threshold for being called 'hypertension'?
What is the live birth rate in women taking Pentoxifylline
What is the long term effect of steroid use for asthma on bones?
What is the mechanism of late effects in adult testicular germ cell tumours?
What is the minimum effective dose of magnesium sulphate for women with pre-eclampsia, and when should it be started?
What is the most effective strategy to educate people with asthma and health professionals about managing the adverse effects of drug therapies?
What is the most effective treatment for peritoneal dialysis-associated peritonitis?
What is the most effective treatment for Vestibular migraine?
What is the most effective way of managing asthma triggers?
What is the most effective way of managing asthma with other conditions?
What is the most effective way to maintain weight loss in adults?
What is the most effective way to manage consultations and asthma control in adolescence and young people?
What is the natural history of incidental venous thromboembolism?
What is the optimal dialysis dose and frequency in Acute Kidney Injury?
What is the optimal dose and duration of anticoagulant therapy for superficial vein thrombosis or thrombophlebitis?
What is the optimal dose and duration of corticosteroid treatment for acute exacerbations of Chronic obstructive pulmonary disease
What is the optimal dosing and frequency of B12 injections to treat a person with pernicious anaemia?
What is the optimal level of blood glucose monitoring for the individual with diabetes?
What is the optimal management of partial epilepsy uncontrolled by a first choice anticonvulsant?
What is the optimal method for controlling glycaemia during labour and birth?
What is the optimal process for GP education and training for improved diagnosis and management of balance disorders?
What is the optimal surveillance regime to improve ocular hypertension?
What is the optimal time of day to take epilepsy medication?
What is the optimal use of combination treatments and the adverse effects of treatments for hyperkalaemia?
What is the optimal way of screening for and treating gestational diabetes?
What is the optimal way to take medication?
What is the optimum age for epilepsy surgery?
What is the optimum antibiotic treatment for acute chest syndrome in people with sickle cell disease?
What is the optimum dosage of oral steroids in children with asthma?
What is the optimum management of poor prognosis adult testicular germ cell tumours?
What is the optimum management of relapsed adult testicular germ cell tumours?
What is the optimum management of seminoma IIA/B in adults with testicular germ cell tumours?
What is the optimum pharmacological strategy for the management of patients with balance disorders?
What is the optimum pharmacological strategy for the management of patients with Ménière's disease? In particular, what are the effects of betahistine (including long term effects)?
What is the optimum timing and best immunosuppressive treatment for re-transplantation in patients with Post Transplant Lymphoproliferative Disorders?
What is the optimum timing to administer thromboprophylaxis during pregnancy and the puerperium?
What is the prevalence of late effects in adult testicular germ cell tumours?
What is the risk for CHD in patients with psoriasis, and does the risk change by severity and whether the risk varies by gender, race, or other concomitant risk factors?
What is the role of anti-viral agents in conjunction with chemotherapy in patients with Post Transplant Lymphoproliferative Disorders?
What is the role of complementary therapies in asthma management?
What is the role of immunosuppression reduction versus chemotherapy in non-EBV related PTLD?
What is the role of immunosuppressive therapy in IgA Nephropathy?
What is the role of negative D--dimer in excluding deep vein thrombosis in high and moderate risk patients with a first negative ultrasound scan during pregnancy and the puerperium?
What is the role of PET scanning in detecting and monitoring Post Transplant Lymphoproliferative Disorders?
What is the specificity and sensitivity of anti-cyclic citrullinated peptide in diagnosing early rheumatoid arthritis
What is the therapeutic role of aliskiren in proteinuria reduction?
What is the value of complementary medicines such as Buteyko method for people with asthma?
What is the value of using inhaled steroids continuously, versus a short course of oral steroids when the need arises if one doesn't have regular asthma attacks?
What makes self management successful for some people with type 1 diabetes and not others?
What medication could be used to help achieve regular bowel movements for Lymphocytic Ganglionitis?
What other medicines are safe when you have asthma and a cold or need pain relief?
What peak flow scores indicate caution, and then alarm, for a person with asthma, and when would I need to review my medication and/or go back to the asthma nurse?
What precautions do I need to consider as a person with asthma when flying?
What role does patient preference play in deciding which inhaler to prescribe for someone with asthma? Does this improve compliance and effectiveness?
What role does positron emission tomography/computed tomography have in management of late relapses in adults with testicular germ cell tumours?
What role does positron emission tomography/computed tomography have in prediction of response to chemotherapy in adults with testicular germ cell tumours?
What role might chemotherapy treatments play in treating vitiligo?
What role might gene therapy play in the treatment of vitiligo?
What role might stem cell therapy play in treating vitiligo?
What should be the sequence of acne therapy (first-line, second-line, and third-line)?
What should you do if you forget to take your epilepsy medication?
What strategies /interventions have been investigated to improve compliance for people with asthma with: medication regimens; self-management practices and general asthma health promoting behaviour?
What strategies are most effective for long-term maintenance of healthy weight or reduced weight following initial treatment of obesity?
What techniques could be developed to check blood sugar levels other than finger prick testing?
What therapy can reduce neurological pain triggered by urinary incontinence in multiple sclerosis?
What treatments are available for children with asthma other than medications?
What treatments are best for insomnia whilst taking antipsychotic drugs for schizophrenia?
What treatments are effective for pyoderma gangrenosum?
What treatments are effective in managing neuropathy?
What treatments are helpful for diabetic hand complications?
What treatments, including psychological support services, are effective to manage the psychological effects of type 1 diabetes?
What type of inhaler is the most effective for different age groups?
What type of patient (children and adults) and health professional education is most effective in gaining asthma control?
What will be the potential benefits to people with diabetes of Smart insulin?
Wheat-based oral rehydration solution for acute watery diarrhoea
When is the best time to consider depigmentation?
When managing patients with proximal femoral fracture, which approach to pre-hospital pain management achieves the most effective analgesia; morphine sulphate, ketamine or femoral nerve block?
When should a viral infection prompt an increase in asthma medication in children?
When should I go to see the GP when having an asthma attack for emergency steroids?
When would it be worthwhile having oxygen or other emergency equipment at home to treat asthma?
Whether addition of bladder training to other forms of management of overactive bladder symptoms (including incontinence) is useful
Whether calcium supplementation for prevention of pre-eclampsia influences the health of the womens' children.
Whether one method of administration of anticholinerigic drugs for Overactive Bladder Syndrome, is better than another, and if so when.
Which adverse effects from antipsychotic drugs do patients find most difficult to cope with?
Which anticholinergic drug for overactive bladder symptoms
Which anticholinergic drug for overactive bladder symptoms in adults
Which are the most beneficial types of work-related day-time activities for schizophrenia and other serious mental health problems?
Which bacterial species in the human intestine are responsible for the generation of trimethylamine?
Which bladder management strategies are most effective for a neurogenic bladder in Spina Bifida?
Which cases of superficial vein thrombosis or thrombophlebitis require imaging to exclude concurrent deep vein thrombosis?
Which components of nurse follow up produce the greatest benefits for patients with heart failure
Which drug provides better protection for preventing the progression of diabetic kidney disease: angiotension converting enzyme inhibitors or antiotensin II receptor antagonists?
Which ethnic, religious, language or racial identity factors hinder engagement for people with schizophrenia from Black and Minority Ethnic groupss?
Which factors influence adherence to treatments for psoriatic arthritis?
Which form of vestibular rehabilitation is most effective for unilateral peripheral vestibular dysfunction?
Which individuals with schizophrenia would most benefit from Family Interventions?
Which insulins are safest and have the fewest adverse effects?
Which is the best psychotherapy for the treatment of psychosis?
Which is the best treatment, heparin or thrombolysis in high-risk pulmonary embolism patients?
Which is the best way to manage aggression in schizophrenia?
Which is the most effective cerumenolytic for ear syringing for ear wax removal?
Which is the most effective treatment in end-stage renal failure: haemodiafiltration or haemodialysis?
Which management strategies are most effective for the management of neurogenic bladder following spinal cord injury?
Which non-corticosteroid treatments are effective for nephrotic syndrome in children?
Which patients benefit most from cardiac resynchronization therapy (CRT) or cardiac resynchronization therapy device and defibrillator (CRT-D)
Which patients benefit most from Implanted Arrhythmia Controlled Devices (ICD) implantation
Which topical combination therapy is best for mild to moderate facial acne?
Which treatment is more effective for vitiligo: calcineurin inhibitors (e.g. tacrolimus, pimecrolimus) or light therapy?
Which treatment is more effective for vitiligo: calcineurin inhibitors (e.g. tacrolimus, pimecrolimus) or steroid cream?
Which treatment is more effective for vitiligo: calcineurin inhibitors (e.g. tacrolimus, pimecrolimus) or steroid creams/ointments?
Which treatment is more effective for vitiligo: calcineurin inhibitors (e.g. tacrolimus, pimecrolimus) or vitamin D analogues (e.g. calcipotriol)?
Which treatment is more effective for vitiligo: laser or other light therapy?
Which treatment is more effective for vitiligo: light therapy or calcineurin inhibitors (e.g. tacrolimus, pimecrolimus)?
Which treatment is more effective for vitiligo: melagenina or UV light?
Which treatment is more effective for vitiligo: psoralen taken by mouth or psoralen cream/ointment?
Which treatment is more effective for vitiligo: steroid cream or a different cream that suppresses the immune system?
Which treatment is more effective for vitiligo: steroid creams/ointments or light therapy?
Which treatment options are most effective in the management of nocturnal enuresis?
Which treatments are more effective for improving the quality of life of patients with vitiligo: psychological interventions or treatments to aid repigmentation?
Which type of insulin is most effective?
Which types of psychosocial interventions are effective for people with diabetes?
Which women benefit from thromboprophylaxis during pregnancy and the puerperium?
Who is the best person within a multi-disciplinary team to treat people when they first present with seizures?
Who is the best person within a multi-disciplinary team to treat people whose seizure pattern is changing?
Who should be offered psychosocial care: people with diabetes of all ages or just those of a certain age?
Who should be offered psychosocial care: those who have poor diabetes management or all people with diabetes?
Whole body cooling versus selective head cooling for newborns with hypoxic ischaemic encephalopathy
Whole brain radiotherapy for the treatment of multiple brain metastases
Why do patients not have nebulisers prescribed by their GP to use at home to prevent asthma attacks, and possibly avoid admission to hospital?
Why is the better (but more expensive) insulin pumps and continuous glucose monitoring systems not more available for the treatment of type 1 diabetes, even though they would save the NHS money in the long term due to lower incidence of related conditions/complications?
Will avoiding low energy saving lightbulbs improve my epilepsy?
Will breast feeding reduce the chances of a baby developing atopic eczema?
Will changing location to a warmer climate help children's asthma?
Will exercise affect my asthma?
Will how I position myself to get to sleep help improve my asthma?
Will noscapine provide a treatment or control for prostate cancer progression in post prostatectomy patients?
Will taking steroids for asthma cause me long term health problems?
Will treating psychological distress including depression and anxiety in adults with psoriasis and psoriatic arthritis have an effect on disease severity and flare-ups?
Withdrawal of medications for sleep-related epilepsy
Workplace interventions for neck pain in workers
Workplace interventions for treatment of occupational asthma
Would a comprehensive biochemical screening test for trimethylaminuria help patients?
Would an antibiotic (oral or topical) devoid of immunomodulatory effects show any therapeutic benefit in acne vulgaris?
Would changes in my antipsychotic medication help my concentration improve?
Would complications of pernicious anaemia, such as peripheral neuropathy or sub acute combined degeneration of the spinal cord, be avoided by more flexible dosing of B12, targeted to the patients symptoms?
Would day care intravenous therapy speed discharge and avoid readmission in patients with chronic heart failure?
Would patients with pernicious anaemia have better outcomes if they had access to other forms of injections of B12: such as cyanocobalamin or methylcobalamin?
Would prostate cancer screening targeted at high risk groups, i.e. those with positive family history, and ethnic minorities with higher rates, improve the outcomes of treatment in these groups?
Wound drains following thyroid surgery
Written action plans for asthma in children
Xylitol for preventing acute otitis media in children up to 12 years of age
Yoga for the treatment of mild multiple sclerosis
Zinc for age-related macular degeneration to prevent progression
Zinc for the common cold
Zinc for the prevention of diarrhoea in children with HIV infection or exposure to maternal HIV infection
Zinc or chelator agents for initial monotherapy in Wilson's disease
Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age
Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months
Zinc supplements for preventing otitis media